AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid

Adeno‐associated virus (AAV) has many properties of an ideal vector for delivery of therapeutic genes into the myocardium. Previous studies in a mouse model of myocardial infarction showed that AAV serotype 1 (AAV1) is superior to AAV serotypes 2–5 to transfer genes into the myocardium by direct inj...

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Veröffentlicht in:	The journal of gene medicine 2008-01, Vol.10 (1), p.33-41
Hauptverfasser:	Su, H., Yeghiazarians, Y., Lee, A., Huang, Y., Arakawa-Hoyt, J., Ye, J., Orcino, G., Grossman, W., Kan, Y. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus angiogenesis Animals beta-Galactosidase - genetics Blood Vessels - cytology Cell Line Cytomegalovirus Dependovirus - classification Dependovirus - metabolism Female Gene Expression Regulation Gene therapy gene transduction Gene Transfer Techniques Humans Immunohistochemistry Injections Myocardium - cytology Myocardium - metabolism pig myocardium Plasmids - metabolism RNA, Messenger serotypes Serotyping Swine vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics
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