Bioinformatics analysis of functional protein sequences reveals a role for brain-derived neurotrophic factor in obesity and type 2 diabetes mellitus
Summary Using bioinformatics techniques and sequence analyses algorithms, a comparative study between human and rodents revealed similarity in the behavior of genes involved in the control of energy homeostasis. Brain-derived neurotrophic factor (BDNF) modulates the secretion and actions of insulin,...
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| Veröffentlicht in: | Medical hypotheses 2008-01, Vol.70 (2), p.424-429 |
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| creator | Rao, Allam Appa Sridhar, Gumpeny R Srinivas, Bolem Das, Undurti N |
| description | Summary Using bioinformatics techniques and sequence analyses algorithms, a comparative study between human and rodents revealed similarity in the behavior of genes involved in the control of energy homeostasis. Brain-derived neurotrophic factor (BDNF) modulates the secretion and actions of insulin, leptin, ghrelin, various neurotransmitters and peptides, and pro-inflammatory cytokines involved in energy homeostasis suggesting that it (BDNF) has a significant role in the pathobiology of obesity and type 2 diabetes mellitus. Based on these evidences, we propose that obesity and type 2 diabetes could be disorders of the brain and BDNF could serve as a biomarker in predicting their development. Hence, methods developed to selectively deliver BDNF to appropriate hypothalamic neurons may form a novel approach in their treatment. |
| doi_str_mv | 10.1016/j.mehy.2007.03.034 |
| format | Article |
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Brain-derived neurotrophic factor (BDNF) modulates the secretion and actions of insulin, leptin, ghrelin, various neurotransmitters and peptides, and pro-inflammatory cytokines involved in energy homeostasis suggesting that it (BDNF) has a significant role in the pathobiology of obesity and type 2 diabetes mellitus. Based on these evidences, we propose that obesity and type 2 diabetes could be disorders of the brain and BDNF could serve as a biomarker in predicting their development. 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Brain-derived neurotrophic factor (BDNF) modulates the secretion and actions of insulin, leptin, ghrelin, various neurotransmitters and peptides, and pro-inflammatory cytokines involved in energy homeostasis suggesting that it (BDNF) has a significant role in the pathobiology of obesity and type 2 diabetes mellitus. Based on these evidences, we propose that obesity and type 2 diabetes could be disorders of the brain and BDNF could serve as a biomarker in predicting their development. 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| identifier | ISSN: 0306-9877 |
| ispartof | Medical hypotheses, 2008-01, Vol.70 (2), p.424-429 |
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| language | eng |
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| subjects | Animals Biomarkers Brain - physiopathology Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - physiology Computational Biology Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - physiopathology Energy Metabolism Ghrelin - physiology Homeostasis Humans Insulin - physiology Internal Medicine Leptin - physiology Melanocortins - physiology Mice Models, Biological Obesity - etiology Obesity - genetics Obesity - physiopathology Phylogeny Sequence Alignment Species Specificity |
| title | Bioinformatics analysis of functional protein sequences reveals a role for brain-derived neurotrophic factor in obesity and type 2 diabetes mellitus |
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