Noradrenergic antagonism enhances the conditioned aversive effects of cocaine

The propensity to self-administer cocaine may be a function of both its positively reinforcing and aversive effects, with the latter acting as a limiting factor on overall drug taking. However, relative to what is known about the physiological underpinnings of cocaine's positively reinforcing e...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2008-02, Vol.88 (4), p.523-532
Hauptverfasser:	Freeman, Kevin B., Verendeev, Andrey, Riley, Anthony L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Antagonists - pharmacology Adrenergic beta-Antagonists - pharmacology Animals Avoidance Learning - drug effects Biological and medical sciences Cocaine Cocaine - pharmacology Conditioned taste aversion Conditioning, Operant - drug effects Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Male Medical sciences Neuropharmacology Norepinephrine Norepinephrine - antagonists & inhibitors Pharmacology. Drug treatments Prazosin Prazosin - pharmacology Propanolol Propranolol - pharmacology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Sympathetic Nervous System - drug effects Taste - drug effects
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