Determination of tegaserod by LC–ESI-MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers

A simple, rapid and sensitive high performance liquid chromatography–electrospray ionization-tandem mass spectrometry (HPLC–ESI-MS/MS) assay for determination of tegaserod in human plasma using diazepam as internal standard (IS) was established. After adjustment to a basic pH with sodium hydroxide,...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2008, Vol.861 (1), p.151-157
Hauptverfasser:	Zou, Jian-Jun, Bian, Xiao-Jie, Ding, Li, Zhu, Yu-Bin, Fan, Hong-Wei, Xiao, Da-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Area Under Curve Biological and medical sciences Calibration Chromatography, High Pressure Liquid - methods Fundamental and applied biological sciences. Psychology General pharmacology Humans Indoles - blood Indoles - pharmacokinetics Indoles - standards LC–ESI-MS/MS Medical sciences Pharmacokinetics Pharmacology. Drug treatments Reference Standards Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry - methods Tegaserod
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