A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs
Background Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gast...
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| Veröffentlicht in: | Surgery 2008, Vol.143 (1), p.72-78 |
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| creator | Song, Geng-Qing, MD, PhD Hou, Xiaohua, MD, PhD Yang, Bin, MD, PhD Sun, Yan, MD, PhD Qian, Wei, BS Chen, J.D.Z., PhD |
| description | Background Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia and emetic responses. Methods Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed of a short pulse followed with a long pulse, and stimulation was delivered at 2 different locations. The study was performed to test the effects of this new method of GES on vasopressin-induced delayed gastric emptying of solids, gastric dysrhythmia, and emetic responses. Results (1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed gastric emptying of solids ( P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel dual-pulse GES was capable of improving dysrhythmia and emetic responses ( P < .01). Conclusions The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying of solids and improving dysrhythmia and emetic responses induced by vasopressin. This new method of GES may have a potential for gastroparesis. |
| doi_str_mv | 10.1016/j.surg.2007.07.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70165737</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0039606007003996</els_id><sourcerecordid>70165737</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-3daca8687a4e7809f092cd8fcef6eaf668e4a9817f4189b62e27532bab077b1a3</originalsourceid><addsrcrecordid>eNp9ksGKFDEQhoMo7uzqC3iQXNxbj5XunqQbRFgWXYUFD-o5ZNLVsxnTyZjqXpi3N2EGFzwIgYTw1U_VlzD2RsBagJDv92ta0m5dA6h1WSCesZXYNHWlGimesxVA01cSJFywS6I9APSt6F6yC9GJTds3mxWbbniIj-j5hPNDHHgceV3ZBxNCvhsW46vD4gn5ztCcnOXo0ZaD8ZxmNy3ezC4G7qZDyjHEKXo3PNHTYT66sOMu8CHu6BV7MZoc9_q8X7Gfnz_9uP1S3X-7-3p7c1_ZtmvmqhmMNZ3slGlRddCP0Nd26EaLo0QzStlha_pOqDGP029ljbXKY2_NFpTaCtNcsetTbu7q94I068mRRe9NwLiQVlnfRjUqg_UJtCkSJRz1IbnJpKMWoItkvddFsi6SdVkgctHbc_qynXB4KjlbzcC7M2AomxqTCdbRXy5ntbn7PnMfThxmF48OkybrMFgcXMqa9RDd__v4-E-59S6Ut_mFR6R9XFLIlrXQVGvQ38t3KL8BVDn1svkDgrOxXQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70165737</pqid></control><display><type>article</type><title>A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Song, Geng-Qing, MD, PhD ; Hou, Xiaohua, MD, PhD ; Yang, Bin, MD, PhD ; Sun, Yan, MD, PhD ; Qian, Wei, BS ; Chen, J.D.Z., PhD</creator><creatorcontrib>Song, Geng-Qing, MD, PhD ; Hou, Xiaohua, MD, PhD ; Yang, Bin, MD, PhD ; Sun, Yan, MD, PhD ; Qian, Wei, BS ; Chen, J.D.Z., PhD</creatorcontrib><description>Background Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia and emetic responses. Methods Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed of a short pulse followed with a long pulse, and stimulation was delivered at 2 different locations. The study was performed to test the effects of this new method of GES on vasopressin-induced delayed gastric emptying of solids, gastric dysrhythmia, and emetic responses. Results (1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed gastric emptying of solids ( P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel dual-pulse GES was capable of improving dysrhythmia and emetic responses ( P < .01). Conclusions The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying of solids and improving dysrhythmia and emetic responses induced by vasopressin. This new method of GES may have a potential for gastroparesis.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2007.07.001</identifier><identifier>PMID: 18154935</identifier><identifier>CODEN: SURGAZ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Animals ; Biological and medical sciences ; Dogs ; Electric Stimulation - methods ; Female ; Gastric Emptying - drug effects ; Gastric Emptying - physiology ; General aspects ; Medical sciences ; Motion Sickness - chemically induced ; Motion Sickness - physiopathology ; Myoelectric Complex, Migrating - physiology ; Periodicity ; Stomach - physiology ; Surgery ; Time Factors ; Vasopressins - pharmacology ; Vomiting - chemically induced ; Vomiting - physiopathology</subject><ispartof>Surgery, 2008, Vol.143 (1), p.72-78</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-3daca8687a4e7809f092cd8fcef6eaf668e4a9817f4189b62e27532bab077b1a3</citedby><cites>FETCH-LOGICAL-c483t-3daca8687a4e7809f092cd8fcef6eaf668e4a9817f4189b62e27532bab077b1a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.surg.2007.07.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20049819$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18154935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Geng-Qing, MD, PhD</creatorcontrib><creatorcontrib>Hou, Xiaohua, MD, PhD</creatorcontrib><creatorcontrib>Yang, Bin, MD, PhD</creatorcontrib><creatorcontrib>Sun, Yan, MD, PhD</creatorcontrib><creatorcontrib>Qian, Wei, BS</creatorcontrib><creatorcontrib>Chen, J.D.Z., PhD</creatorcontrib><title>A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia and emetic responses. Methods Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed of a short pulse followed with a long pulse, and stimulation was delivered at 2 different locations. The study was performed to test the effects of this new method of GES on vasopressin-induced delayed gastric emptying of solids, gastric dysrhythmia, and emetic responses. Results (1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed gastric emptying of solids ( P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel dual-pulse GES was capable of improving dysrhythmia and emetic responses ( P < .01). Conclusions The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying of solids and improving dysrhythmia and emetic responses induced by vasopressin. This new method of GES may have a potential for gastroparesis.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dogs</subject><subject>Electric Stimulation - methods</subject><subject>Female</subject><subject>Gastric Emptying - drug effects</subject><subject>Gastric Emptying - physiology</subject><subject>General aspects</subject><subject>Medical sciences</subject><subject>Motion Sickness - chemically induced</subject><subject>Motion Sickness - physiopathology</subject><subject>Myoelectric Complex, Migrating - physiology</subject><subject>Periodicity</subject><subject>Stomach - physiology</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Vasopressins - pharmacology</subject><subject>Vomiting - chemically induced</subject><subject>Vomiting - physiopathology</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ksGKFDEQhoMo7uzqC3iQXNxbj5XunqQbRFgWXYUFD-o5ZNLVsxnTyZjqXpi3N2EGFzwIgYTw1U_VlzD2RsBagJDv92ta0m5dA6h1WSCesZXYNHWlGimesxVA01cSJFywS6I9APSt6F6yC9GJTds3mxWbbniIj-j5hPNDHHgceV3ZBxNCvhsW46vD4gn5ztCcnOXo0ZaD8ZxmNy3ezC4G7qZDyjHEKXo3PNHTYT66sOMu8CHu6BV7MZoc9_q8X7Gfnz_9uP1S3X-7-3p7c1_ZtmvmqhmMNZ3slGlRddCP0Nd26EaLo0QzStlha_pOqDGP029ljbXKY2_NFpTaCtNcsetTbu7q94I068mRRe9NwLiQVlnfRjUqg_UJtCkSJRz1IbnJpKMWoItkvddFsi6SdVkgctHbc_qynXB4KjlbzcC7M2AomxqTCdbRXy5ntbn7PnMfThxmF48OkybrMFgcXMqa9RDd__v4-E-59S6Ut_mFR6R9XFLIlrXQVGvQ38t3KL8BVDn1svkDgrOxXQ</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Song, Geng-Qing, MD, PhD</creator><creator>Hou, Xiaohua, MD, PhD</creator><creator>Yang, Bin, MD, PhD</creator><creator>Sun, Yan, MD, PhD</creator><creator>Qian, Wei, BS</creator><creator>Chen, J.D.Z., PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs</title><author>Song, Geng-Qing, MD, PhD ; Hou, Xiaohua, MD, PhD ; Yang, Bin, MD, PhD ; Sun, Yan, MD, PhD ; Qian, Wei, BS ; Chen, J.D.Z., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-3daca8687a4e7809f092cd8fcef6eaf668e4a9817f4189b62e27532bab077b1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dogs</topic><topic>Electric Stimulation - methods</topic><topic>Female</topic><topic>Gastric Emptying - drug effects</topic><topic>Gastric Emptying - physiology</topic><topic>General aspects</topic><topic>Medical sciences</topic><topic>Motion Sickness - chemically induced</topic><topic>Motion Sickness - physiopathology</topic><topic>Myoelectric Complex, Migrating - physiology</topic><topic>Periodicity</topic><topic>Stomach - physiology</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Vasopressins - pharmacology</topic><topic>Vomiting - chemically induced</topic><topic>Vomiting - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Geng-Qing, MD, PhD</creatorcontrib><creatorcontrib>Hou, Xiaohua, MD, PhD</creatorcontrib><creatorcontrib>Yang, Bin, MD, PhD</creatorcontrib><creatorcontrib>Sun, Yan, MD, PhD</creatorcontrib><creatorcontrib>Qian, Wei, BS</creatorcontrib><creatorcontrib>Chen, J.D.Z., PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Geng-Qing, MD, PhD</au><au>Hou, Xiaohua, MD, PhD</au><au>Yang, Bin, MD, PhD</au><au>Sun, Yan, MD, PhD</au><au>Qian, Wei, BS</au><au>Chen, J.D.Z., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2008</date><risdate>2008</risdate><volume>143</volume><issue>1</issue><spage>72</spage><epage>78</epage><pages>72-78</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><coden>SURGAZ</coden><abstract>Background Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia and emetic responses. Methods Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed of a short pulse followed with a long pulse, and stimulation was delivered at 2 different locations. The study was performed to test the effects of this new method of GES on vasopressin-induced delayed gastric emptying of solids, gastric dysrhythmia, and emetic responses. Results (1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed gastric emptying of solids ( P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel dual-pulse GES was capable of improving dysrhythmia and emetic responses ( P < .01). Conclusions The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying of solids and improving dysrhythmia and emetic responses induced by vasopressin. This new method of GES may have a potential for gastroparesis.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>18154935</pmid><doi>10.1016/j.surg.2007.07.001</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Dogs Electric Stimulation - methods Female Gastric Emptying - drug effects Gastric Emptying - physiology General aspects Medical sciences Motion Sickness - chemically induced Motion Sickness - physiopathology Myoelectric Complex, Migrating - physiology Periodicity Stomach - physiology Surgery Time Factors Vasopressins - pharmacology Vomiting - chemically induced Vomiting - physiopathology |
| title | A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs |
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