Trafficking and Cellular Distribution of Voltage-Gated Sodium Channels
Electrical excitability in cells such as neurons and myocytes depends not only upon the expression of voltage-gated sodium channels but also on their correct targeting within the plasma membrane. Placing sodium channels within a broader cell biological context is beginning to shed new light on a var...
Gespeichert in:
| Veröffentlicht in: | Traffic (Copenhagen, Denmark) Denmark), 2008-01, Vol.9 (1), p.17-26 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 26 |
|---|---|
| container_issue | 1 |
| container_start_page | 17 |
| container_title | Traffic (Copenhagen, Denmark) |
| container_volume | 9 |
| creator | Cusdin, Fiona S Clare, Jeffrey J Jackson, Antony P |
| description | Electrical excitability in cells such as neurons and myocytes depends not only upon the expression of voltage-gated sodium channels but also on their correct targeting within the plasma membrane. Placing sodium channels within a broader cell biological context is beginning to shed new light on a variety of important questions such as the integration of neuronal signaling. Mutations that affect sodium channel trafficking have been shown to underlie several life-threatening conditions including cardiac arrhythmias, revealing an important clinical context to these studies. |
| doi_str_mv | 10.1111/j.1600-0854.2007.00673.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70165654</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70165654</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4563-f4210ec8646414654afca55a9e0572a46a78b556375674d42ef203c65af868c33</originalsourceid><addsrcrecordid>eNqNkF1P2zAUhq2JCTrgL4xccZfs-DOOxA0qazep0iQo3FqniV3cpQnYiYB_P5dW4xbf-Eh-3vdYDyEZhYKm82NTUAWQg5aiYABlAaBKXrx-IZP_D0dp5pXOK0arE_Itxg0AMCnEMTmhZaU1Y2JCZsuAzvn6r-_WGXZNNrVtO7YYshsfh-BX4-D7Lutd9tC3A65tPsfBNtld3_hxm00fsetsG8_IV4dttOeH-5Tcz34up7_yxZ_57-n1Iq-FVDx3glGwtVZCCSqUFOhqlBIrC7JkKBSWeiUTWUpVikYw6xjwWkl0Wuma81Nyue99Cv3zaONgtj7W6cvY2X6MpgSqZOpNoN6DdehjDNaZp-C3GN4MBbNzaDZmp8rsVJmdQ_Pu0Lym6PfDjnG1tc1H8CAtAVd74MW39u3TxWZ5e52GFL_Yxx32BtfBR3N_x4ByAM2VFor_AwR8hy8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70165654</pqid></control><display><type>article</type><title>Trafficking and Cellular Distribution of Voltage-Gated Sodium Channels</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>IngentaConnect Free/Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><creator>Cusdin, Fiona S ; Clare, Jeffrey J ; Jackson, Antony P</creator><creatorcontrib>Cusdin, Fiona S ; Clare, Jeffrey J ; Jackson, Antony P</creatorcontrib><description>Electrical excitability in cells such as neurons and myocytes depends not only upon the expression of voltage-gated sodium channels but also on their correct targeting within the plasma membrane. Placing sodium channels within a broader cell biological context is beginning to shed new light on a variety of important questions such as the integration of neuronal signaling. Mutations that affect sodium channel trafficking have been shown to underlie several life-threatening conditions including cardiac arrhythmias, revealing an important clinical context to these studies.</description><identifier>ISSN: 1398-9219</identifier><identifier>EISSN: 1600-0854</identifier><identifier>DOI: 10.1111/j.1600-0854.2007.00673.x</identifier><identifier>PMID: 17988224</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Animals ; axon initial segment ; binding motifs ; cardiac myocyte ; Cell Membrane - metabolism ; endocytosis ; Humans ; Myocytes, Cardiac - metabolism ; neuron ; Neurons - metabolism ; node of Ranvier ; Protein Transport ; Sodium Channels - metabolism ; voltage-gated sodium channels</subject><ispartof>Traffic (Copenhagen, Denmark), 2008-01, Vol.9 (1), p.17-26</ispartof><rights>2007 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4563-f4210ec8646414654afca55a9e0572a46a78b556375674d42ef203c65af868c33</citedby><cites>FETCH-LOGICAL-c4563-f4210ec8646414654afca55a9e0572a46a78b556375674d42ef203c65af868c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0854.2007.00673.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0854.2007.00673.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17988224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cusdin, Fiona S</creatorcontrib><creatorcontrib>Clare, Jeffrey J</creatorcontrib><creatorcontrib>Jackson, Antony P</creatorcontrib><title>Trafficking and Cellular Distribution of Voltage-Gated Sodium Channels</title><title>Traffic (Copenhagen, Denmark)</title><addtitle>Traffic</addtitle><description>Electrical excitability in cells such as neurons and myocytes depends not only upon the expression of voltage-gated sodium channels but also on their correct targeting within the plasma membrane. Placing sodium channels within a broader cell biological context is beginning to shed new light on a variety of important questions such as the integration of neuronal signaling. Mutations that affect sodium channel trafficking have been shown to underlie several life-threatening conditions including cardiac arrhythmias, revealing an important clinical context to these studies.</description><subject>Animals</subject><subject>axon initial segment</subject><subject>binding motifs</subject><subject>cardiac myocyte</subject><subject>Cell Membrane - metabolism</subject><subject>endocytosis</subject><subject>Humans</subject><subject>Myocytes, Cardiac - metabolism</subject><subject>neuron</subject><subject>Neurons - metabolism</subject><subject>node of Ranvier</subject><subject>Protein Transport</subject><subject>Sodium Channels - metabolism</subject><subject>voltage-gated sodium channels</subject><issn>1398-9219</issn><issn>1600-0854</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1P2zAUhq2JCTrgL4xccZfs-DOOxA0qazep0iQo3FqniV3cpQnYiYB_P5dW4xbf-Eh-3vdYDyEZhYKm82NTUAWQg5aiYABlAaBKXrx-IZP_D0dp5pXOK0arE_Itxg0AMCnEMTmhZaU1Y2JCZsuAzvn6r-_WGXZNNrVtO7YYshsfh-BX4-D7Lutd9tC3A65tPsfBNtld3_hxm00fsetsG8_IV4dttOeH-5Tcz34up7_yxZ_57-n1Iq-FVDx3glGwtVZCCSqUFOhqlBIrC7JkKBSWeiUTWUpVikYw6xjwWkl0Wuma81Nyue99Cv3zaONgtj7W6cvY2X6MpgSqZOpNoN6DdehjDNaZp-C3GN4MBbNzaDZmp8rsVJmdQ_Pu0Lym6PfDjnG1tc1H8CAtAVd74MW39u3TxWZ5e52GFL_Yxx32BtfBR3N_x4ByAM2VFor_AwR8hy8</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Cusdin, Fiona S</creator><creator>Clare, Jeffrey J</creator><creator>Jackson, Antony P</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200801</creationdate><title>Trafficking and Cellular Distribution of Voltage-Gated Sodium Channels</title><author>Cusdin, Fiona S ; Clare, Jeffrey J ; Jackson, Antony P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4563-f4210ec8646414654afca55a9e0572a46a78b556375674d42ef203c65af868c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>axon initial segment</topic><topic>binding motifs</topic><topic>cardiac myocyte</topic><topic>Cell Membrane - metabolism</topic><topic>endocytosis</topic><topic>Humans</topic><topic>Myocytes, Cardiac - metabolism</topic><topic>neuron</topic><topic>Neurons - metabolism</topic><topic>node of Ranvier</topic><topic>Protein Transport</topic><topic>Sodium Channels - metabolism</topic><topic>voltage-gated sodium channels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cusdin, Fiona S</creatorcontrib><creatorcontrib>Clare, Jeffrey J</creatorcontrib><creatorcontrib>Jackson, Antony P</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Traffic (Copenhagen, Denmark)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cusdin, Fiona S</au><au>Clare, Jeffrey J</au><au>Jackson, Antony P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trafficking and Cellular Distribution of Voltage-Gated Sodium Channels</atitle><jtitle>Traffic (Copenhagen, Denmark)</jtitle><addtitle>Traffic</addtitle><date>2008-01</date><risdate>2008</risdate><volume>9</volume><issue>1</issue><spage>17</spage><epage>26</epage><pages>17-26</pages><issn>1398-9219</issn><eissn>1600-0854</eissn><abstract>Electrical excitability in cells such as neurons and myocytes depends not only upon the expression of voltage-gated sodium channels but also on their correct targeting within the plasma membrane. Placing sodium channels within a broader cell biological context is beginning to shed new light on a variety of important questions such as the integration of neuronal signaling. Mutations that affect sodium channel trafficking have been shown to underlie several life-threatening conditions including cardiac arrhythmias, revealing an important clinical context to these studies.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>17988224</pmid><doi>10.1111/j.1600-0854.2007.00673.x</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1398-9219 |
| ispartof | Traffic (Copenhagen, Denmark), 2008-01, Vol.9 (1), p.17-26 |
| issn | 1398-9219 1600-0854 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70165654 |
| source | MEDLINE; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Animals axon initial segment binding motifs cardiac myocyte Cell Membrane - metabolism endocytosis Humans Myocytes, Cardiac - metabolism neuron Neurons - metabolism node of Ranvier Protein Transport Sodium Channels - metabolism voltage-gated sodium channels |
| title | Trafficking and Cellular Distribution of Voltage-Gated Sodium Channels |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T22%3A09%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Trafficking%20and%20Cellular%20Distribution%20of%20Voltage-Gated%20Sodium%20Channels&rft.jtitle=Traffic%20(Copenhagen,%20Denmark)&rft.au=Cusdin,%20Fiona%20S&rft.date=2008-01&rft.volume=9&rft.issue=1&rft.spage=17&rft.epage=26&rft.pages=17-26&rft.issn=1398-9219&rft.eissn=1600-0854&rft_id=info:doi/10.1111/j.1600-0854.2007.00673.x&rft_dat=%3Cproquest_cross%3E70165654%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70165654&rft_id=info:pmid/17988224&rfr_iscdi=true |