Trafficking and Cellular Distribution of Voltage-Gated Sodium Channels

Electrical excitability in cells such as neurons and myocytes depends not only upon the expression of voltage-gated sodium channels but also on their correct targeting within the plasma membrane. Placing sodium channels within a broader cell biological context is beginning to shed new light on a var...

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Veröffentlicht in:Traffic (Copenhagen, Denmark) Denmark), 2008-01, Vol.9 (1), p.17-26
Hauptverfasser: Cusdin, Fiona S, Clare, Jeffrey J, Jackson, Antony P
Format: Artikel
Sprache:eng
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Zusammenfassung:Electrical excitability in cells such as neurons and myocytes depends not only upon the expression of voltage-gated sodium channels but also on their correct targeting within the plasma membrane. Placing sodium channels within a broader cell biological context is beginning to shed new light on a variety of important questions such as the integration of neuronal signaling. Mutations that affect sodium channel trafficking have been shown to underlie several life-threatening conditions including cardiac arrhythmias, revealing an important clinical context to these studies.
ISSN:1398-9219
1600-0854
DOI:10.1111/j.1600-0854.2007.00673.x