PKA-Bad-14-3-3 and Akt-Bad-14-3-3 signaling pathways are involved in the protective effects of PACAP against ischemia/reperfusion-induced cardiomyocyte apoptosis

The neuropeptide PACAP (pituitary adenylate cyclase activating polypeptide) and its receptors are widely expressed in the nervous system and various other tissues. PACAP has well-known anti-apoptotic effects in neuronal cell lines. Recent data suggest that PACAP exerts anti-apoptotic effects also in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Regulatory peptides 2008-01, Vol.145 (1), p.105-115
Hauptverfasser:	Rácz, B., Gasz, B., Gallyas, F., Kiss, P., Tamás, A., Szántó, Z., Lubics, A., Lengvári, I., Tóth, G., Hegyi, O., Rőth, E., Reglődi, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - metabolism Animals Apoptosis - drug effects bcl-Associated Death Protein - metabolism Bcl-xL Biological and medical sciences Cardiology. Vascular system Cardioprotection Caspase Cells, Cultured Coronary heart disease Cyclic AMP-Dependent Protein Kinases - metabolism Cytoprotection - drug effects Fundamental and applied biological sciences. Psychology Heart Medical sciences Myocardial ischemia Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocarditis. Cardiomyopathies Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Signal Transduction - drug effects Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!