Serum interleukins and urinary microglobulin in children with idiopathic nephrotic syndrome
We studied 60 children affected with idiopathic nephrotic syndrome (INS) plus 20 age and sex matched controls. The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin (IL)-1beta,...
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| Veröffentlicht in: | Eastern Mediterranean health journal 2005-09, Vol.11 (5-6), p.993-1002 |
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| creator | Rizk, M K El-Nawawy, A Abdel-Kareem, E Amer, E S El-Gezairy, D El-Shafei, A Z |
| description | We studied 60 children affected with idiopathic nephrotic syndrome (INS) plus 20 age and sex matched controls. The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF) and quantitative urinary beta-2-microglobulin (beta-2-m) excretion were estimated. IL-1beta and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. Serum TNF concentration and urinary beta-2-m excretion were significantly higher in the first presentation and relapse groups. Serum IL-1beta, IL-6 and TNF concentrations were able to select positively (100%) the first presentation and relapse groups, while these plus urinary beta-2-m excretion selected negatively (100%) the control group. |
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The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF) and quantitative urinary beta-2-microglobulin (beta-2-m) excretion were estimated. IL-1beta and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. Serum TNF concentration and urinary beta-2-m excretion were significantly higher in the first presentation and relapse groups. Serum IL-1beta, IL-6 and TNF concentrations were able to select positively (100%) the first presentation and relapse groups, while these plus urinary beta-2-m excretion selected negatively (100%) the control group.</description><identifier>ISSN: 1020-3397</identifier><identifier>PMID: 16761670</identifier><language>eng</language><publisher>Egypt</publisher><subject>Analysis of Variance ; beta 2-Microglobulin - immunology ; beta 2-Microglobulin - urine ; Blood Urea Nitrogen ; Case-Control Studies ; Chi-Square Distribution ; Child ; Child, Preschool ; Egypt ; Female ; Hemoglobins - metabolism ; Hospitals, Pediatric ; Hospitals, University ; Humans ; Interleukin-1 - blood ; Interleukin-1 - immunology ; Interleukin-6 - blood ; Interleukin-6 - immunology ; Leukocyte Count ; Male ; Nephrotic Syndrome - diagnosis ; Nephrotic Syndrome - drug therapy ; Nephrotic Syndrome - immunology ; Nephrotic Syndrome - metabolism ; Predictive Value of Tests ; Recurrence ; Remission Induction ; Serum Albumin - metabolism ; Treatment Outcome ; Tumor Necrosis Factors - blood ; Tumor Necrosis Factors - immunology</subject><ispartof>Eastern Mediterranean health journal, 2005-09, Vol.11 (5-6), p.993-1002</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16761670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rizk, M K</creatorcontrib><creatorcontrib>El-Nawawy, A</creatorcontrib><creatorcontrib>Abdel-Kareem, E</creatorcontrib><creatorcontrib>Amer, E S</creatorcontrib><creatorcontrib>El-Gezairy, D</creatorcontrib><creatorcontrib>El-Shafei, A Z</creatorcontrib><title>Serum interleukins and urinary microglobulin in children with idiopathic nephrotic syndrome</title><title>Eastern Mediterranean health journal</title><addtitle>East Mediterr Health J</addtitle><description>We studied 60 children affected with idiopathic nephrotic syndrome (INS) plus 20 age and sex matched controls. The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF) and quantitative urinary beta-2-microglobulin (beta-2-m) excretion were estimated. IL-1beta and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. Serum TNF concentration and urinary beta-2-m excretion were significantly higher in the first presentation and relapse groups. Serum IL-1beta, IL-6 and TNF concentrations were able to select positively (100%) the first presentation and relapse groups, while these plus urinary beta-2-m excretion selected negatively (100%) the control group.</description><subject>Analysis of Variance</subject><subject>beta 2-Microglobulin - immunology</subject><subject>beta 2-Microglobulin - urine</subject><subject>Blood Urea Nitrogen</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Egypt</subject><subject>Female</subject><subject>Hemoglobins - metabolism</subject><subject>Hospitals, Pediatric</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Interleukin-1 - blood</subject><subject>Interleukin-1 - immunology</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - immunology</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Nephrotic Syndrome - diagnosis</subject><subject>Nephrotic Syndrome - drug therapy</subject><subject>Nephrotic Syndrome - immunology</subject><subject>Nephrotic Syndrome - metabolism</subject><subject>Predictive Value of Tests</subject><subject>Recurrence</subject><subject>Remission Induction</subject><subject>Serum Albumin - metabolism</subject><subject>Treatment Outcome</subject><subject>Tumor Necrosis Factors - blood</subject><subject>Tumor Necrosis Factors - immunology</subject><issn>1020-3397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDtPwzAcxD2AaGn5CsgTWyTbcR4eUcVLqsQATB0iJ_6bGBw7-CHUb08QZTjdDT-ddHeG1pQwUpSlaFboMsYPQljbcnaBVrRu6kVkjQ4vEPKEjUsQLORP4yKWTuEcjJPhiCczBP9ufZ-tcQuGh9FYFcDhb5NGbJTxs0yjGbCDeQw-LSkenQp-gi0619JGuDr5Br3d373uHov988PT7nZfzJTxVIiK91JXimreEAogK6Eazqq6FEyCAEWrGkBXomVkYEr3jWppy7UipOWUNeUG3fz1zsF_ZYipm0wcwFrpwOfYLa01r8UveH0Ccz-B6uZgpmVk939H-QN7eFzM</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>Rizk, M K</creator><creator>El-Nawawy, A</creator><creator>Abdel-Kareem, E</creator><creator>Amer, E S</creator><creator>El-Gezairy, D</creator><creator>El-Shafei, A Z</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200509</creationdate><title>Serum interleukins and urinary microglobulin in children with idiopathic nephrotic syndrome</title><author>Rizk, M K ; El-Nawawy, A ; Abdel-Kareem, E ; Amer, E S ; El-Gezairy, D ; El-Shafei, A Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-954baf5d1f4701eea59d74256392ae9ed156eef59820c2dfb7d8184fd00841273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analysis of Variance</topic><topic>beta 2-Microglobulin - immunology</topic><topic>beta 2-Microglobulin - urine</topic><topic>Blood Urea Nitrogen</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Egypt</topic><topic>Female</topic><topic>Hemoglobins - metabolism</topic><topic>Hospitals, Pediatric</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Interleukin-1 - blood</topic><topic>Interleukin-1 - immunology</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - immunology</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Nephrotic Syndrome - diagnosis</topic><topic>Nephrotic Syndrome - drug therapy</topic><topic>Nephrotic Syndrome - immunology</topic><topic>Nephrotic Syndrome - metabolism</topic><topic>Predictive Value of Tests</topic><topic>Recurrence</topic><topic>Remission Induction</topic><topic>Serum Albumin - metabolism</topic><topic>Treatment Outcome</topic><topic>Tumor Necrosis Factors - blood</topic><topic>Tumor Necrosis Factors - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rizk, M K</creatorcontrib><creatorcontrib>El-Nawawy, A</creatorcontrib><creatorcontrib>Abdel-Kareem, E</creatorcontrib><creatorcontrib>Amer, E S</creatorcontrib><creatorcontrib>El-Gezairy, D</creatorcontrib><creatorcontrib>El-Shafei, A Z</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Eastern Mediterranean health journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rizk, M K</au><au>El-Nawawy, A</au><au>Abdel-Kareem, E</au><au>Amer, E S</au><au>El-Gezairy, D</au><au>El-Shafei, A Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum interleukins and urinary microglobulin in children with idiopathic nephrotic syndrome</atitle><jtitle>Eastern Mediterranean health journal</jtitle><addtitle>East Mediterr Health J</addtitle><date>2005-09</date><risdate>2005</risdate><volume>11</volume><issue>5-6</issue><spage>993</spage><epage>1002</epage><pages>993-1002</pages><issn>1020-3397</issn><abstract>We studied 60 children affected with idiopathic nephrotic syndrome (INS) plus 20 age and sex matched controls. The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF) and quantitative urinary beta-2-microglobulin (beta-2-m) excretion were estimated. IL-1beta and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. Serum TNF concentration and urinary beta-2-m excretion were significantly higher in the first presentation and relapse groups. Serum IL-1beta, IL-6 and TNF concentrations were able to select positively (100%) the first presentation and relapse groups, while these plus urinary beta-2-m excretion selected negatively (100%) the control group.</abstract><cop>Egypt</cop><pmid>16761670</pmid><tpages>10</tpages></addata></record> |
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| subjects | Analysis of Variance beta 2-Microglobulin - immunology beta 2-Microglobulin - urine Blood Urea Nitrogen Case-Control Studies Chi-Square Distribution Child Child, Preschool Egypt Female Hemoglobins - metabolism Hospitals, Pediatric Hospitals, University Humans Interleukin-1 - blood Interleukin-1 - immunology Interleukin-6 - blood Interleukin-6 - immunology Leukocyte Count Male Nephrotic Syndrome - diagnosis Nephrotic Syndrome - drug therapy Nephrotic Syndrome - immunology Nephrotic Syndrome - metabolism Predictive Value of Tests Recurrence Remission Induction Serum Albumin - metabolism Treatment Outcome Tumor Necrosis Factors - blood Tumor Necrosis Factors - immunology |
| title | Serum interleukins and urinary microglobulin in children with idiopathic nephrotic syndrome |
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