Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients
Background Solid pseudopapillary neoplasm of the pancreas is a distinctive pancreatic neoplasm with low metastatic potential. This study examines clinical differences and prognosis between male and female patients. Methods The medical records of 34 consecutive patients with pancreatic solid pseudopa...
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| Veröffentlicht in: | Surgery 2008, Vol.143 (1), p.29-34 |
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| creator | Machado, Marcel C.C., MD, FACS Machado, Marcel Autran C., MD Bacchella, Telesforo, MD Jukemura, José, MD Almeida, José L., MD Cunha, José E.M., MD |
| description | Background Solid pseudopapillary neoplasm of the pancreas is a distinctive pancreatic neoplasm with low metastatic potential. This study examines clinical differences and prognosis between male and female patients. Methods The medical records of 34 consecutive patients with pancreatic solid pseudopapillary neoplasms between 1990 and 2006 were reviewed. Whenever feasible, organ-preserving operation was performed. Statistical analysis was performed using chi-square and Student t test. Results There were 27 women (79%) and seven men (21%) with median age of 23 years. Mean diameter of the tumor was 7 cm. Tumor size tended to be smaller in patients treated in more recent years. Conservative surgery was possible in 11 patients including spleen-preserving distal pancreatectomy in 3, central pancreatectomy in 5, and enucleation in 3 patients. Median hospital stay was 11 days, morbidity rate was 62%, including 17 patients with grade A pancreatic fistula, and there was no operative mortality. Mean follow-up time was 84 months. Tumor recurred in 2 patients (6%). Overall late morbidity rate was 12%. At the time of diagnosis, age was ( x ¯ ± SD) higher among male patients (25 ± 2 years vs 37 ± 7 years; P |
| doi_str_mv | 10.1016/j.surg.2007.07.030 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70164187</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0039606007005120</els_id><sourcerecordid>70164187</sourcerecordid><originalsourceid>FETCH-LOGICAL-c505t-241786fd30d8c5d52762458c3316b5a1dbf164d71a3a5214de683c13a5333c2c3</originalsourceid><addsrcrecordid>eNp9ks-L1TAQx4so7nP1H_Aguehp-5w0TdsnIsjiL1jwsHoOecl0zbNNaqZd2Lt_uFPfQ8GDMBAm-c43Mx-mKJ5K2EqQzcvDlpZ8s60A2u0aCu4VG6lVVbaqkfeLDYDalQ00cFY8IjoAwK6W3cPiTHZS1zsFm-LndRqCFxPh4tNkpzAMNt-JiGkaLI0i9WL-hmKy0WW09Er4QHOIbuarecYcaZWkSDhf8Ju9iYkCXQgb2TSnYyr6lMVoBxS3mGnhHH9nbBEwzvS4eNDbgfDJ6Twvvr5_9-XyY3n1-cOny7dXpdOg57KqZds1vVfgO6e9rtqmqnXnlJLNXlvp971sat9Kq6yuZO2x6ZSTnCilXOXUefHi6Mud_ViQZjMGcsgj87wLmZapMqCWhdVR6HIiytibKYeRwRgJZmVvDmZlb1b2Zg0FXPTs5L7sR_R_S06wWfD8JLDk7NBnhhroj4696l0na9a9PuqQWdwGzIYcc3LoQ0Y3G5_C__t480-5G0IM_ON3vEM6pCVHpmykocqAuV63ZF0SaAG0rED9ApOhuPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70164187</pqid></control><display><type>article</type><title>Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Machado, Marcel C.C., MD, FACS ; Machado, Marcel Autran C., MD ; Bacchella, Telesforo, MD ; Jukemura, José, MD ; Almeida, José L., MD ; Cunha, José E.M., MD</creator><creatorcontrib>Machado, Marcel C.C., MD, FACS ; Machado, Marcel Autran C., MD ; Bacchella, Telesforo, MD ; Jukemura, José, MD ; Almeida, José L., MD ; Cunha, José E.M., MD</creatorcontrib><description>Background Solid pseudopapillary neoplasm of the pancreas is a distinctive pancreatic neoplasm with low metastatic potential. This study examines clinical differences and prognosis between male and female patients. Methods The medical records of 34 consecutive patients with pancreatic solid pseudopapillary neoplasms between 1990 and 2006 were reviewed. Whenever feasible, organ-preserving operation was performed. Statistical analysis was performed using chi-square and Student t test. Results There were 27 women (79%) and seven men (21%) with median age of 23 years. Mean diameter of the tumor was 7 cm. Tumor size tended to be smaller in patients treated in more recent years. Conservative surgery was possible in 11 patients including spleen-preserving distal pancreatectomy in 3, central pancreatectomy in 5, and enucleation in 3 patients. Median hospital stay was 11 days, morbidity rate was 62%, including 17 patients with grade A pancreatic fistula, and there was no operative mortality. Mean follow-up time was 84 months. Tumor recurred in 2 patients (6%). Overall late morbidity rate was 12%. At the time of diagnosis, age was ( x ¯ ± SD) higher among male patients (25 ± 2 years vs 37 ± 7 years; P <.05) with no difference in tumor size. The neoplasms were more aggressive in male patients; therefore, conservative surgery was less likely. There was no correlation between tumor aggressiveness and age of the patient or size of tumor. Conclusion This is the first single center study to demonstrate that solid pseudopapillary neoplasms in male patients have distinct patterns of onset and aggressiveness when compared with female patients. Although valid prognostic criteria are still lacking, it appears that male patients may be best treated by more radical operation and should be observed more closely during follow-up.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2007.07.030</identifier><identifier>PMID: 18154930</identifier><identifier>CODEN: SURGAZ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Carcinoma, Papillary - chemistry ; Carcinoma, Papillary - diagnosis ; Carcinoma, Papillary - surgery ; Child ; Female ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Humans ; Immunohistochemistry ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local ; Pancreatectomy ; Pancreatic Neoplasms - chemistry ; Pancreatic Neoplasms - diagnosis ; Pancreatic Neoplasms - surgery ; Prognosis ; Sex Factors ; Surgery ; Tomography, X-Ray Computed ; Tumors</subject><ispartof>Surgery, 2008, Vol.143 (1), p.29-34</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-241786fd30d8c5d52762458c3316b5a1dbf164d71a3a5214de683c13a5333c2c3</citedby><cites>FETCH-LOGICAL-c505t-241786fd30d8c5d52762458c3316b5a1dbf164d71a3a5214de683c13a5333c2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.surg.2007.07.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20049814$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18154930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machado, Marcel C.C., MD, FACS</creatorcontrib><creatorcontrib>Machado, Marcel Autran C., MD</creatorcontrib><creatorcontrib>Bacchella, Telesforo, MD</creatorcontrib><creatorcontrib>Jukemura, José, MD</creatorcontrib><creatorcontrib>Almeida, José L., MD</creatorcontrib><creatorcontrib>Cunha, José E.M., MD</creatorcontrib><title>Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background Solid pseudopapillary neoplasm of the pancreas is a distinctive pancreatic neoplasm with low metastatic potential. This study examines clinical differences and prognosis between male and female patients. Methods The medical records of 34 consecutive patients with pancreatic solid pseudopapillary neoplasms between 1990 and 2006 were reviewed. Whenever feasible, organ-preserving operation was performed. Statistical analysis was performed using chi-square and Student t test. Results There were 27 women (79%) and seven men (21%) with median age of 23 years. Mean diameter of the tumor was 7 cm. Tumor size tended to be smaller in patients treated in more recent years. Conservative surgery was possible in 11 patients including spleen-preserving distal pancreatectomy in 3, central pancreatectomy in 5, and enucleation in 3 patients. Median hospital stay was 11 days, morbidity rate was 62%, including 17 patients with grade A pancreatic fistula, and there was no operative mortality. Mean follow-up time was 84 months. Tumor recurred in 2 patients (6%). Overall late morbidity rate was 12%. At the time of diagnosis, age was ( x ¯ ± SD) higher among male patients (25 ± 2 years vs 37 ± 7 years; P <.05) with no difference in tumor size. The neoplasms were more aggressive in male patients; therefore, conservative surgery was less likely. There was no correlation between tumor aggressiveness and age of the patient or size of tumor. Conclusion This is the first single center study to demonstrate that solid pseudopapillary neoplasms in male patients have distinct patterns of onset and aggressiveness when compared with female patients. Although valid prognostic criteria are still lacking, it appears that male patients may be best treated by more radical operation and should be observed more closely during follow-up.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Papillary - chemistry</subject><subject>Carcinoma, Papillary - diagnosis</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Child</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Pancreatectomy</subject><subject>Pancreatic Neoplasms - chemistry</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Prognosis</subject><subject>Sex Factors</subject><subject>Surgery</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks-L1TAQx4so7nP1H_Aguehp-5w0TdsnIsjiL1jwsHoOecl0zbNNaqZd2Lt_uFPfQ8GDMBAm-c43Mx-mKJ5K2EqQzcvDlpZ8s60A2u0aCu4VG6lVVbaqkfeLDYDalQ00cFY8IjoAwK6W3cPiTHZS1zsFm-LndRqCFxPh4tNkpzAMNt-JiGkaLI0i9WL-hmKy0WW09Er4QHOIbuarecYcaZWkSDhf8Ju9iYkCXQgb2TSnYyr6lMVoBxS3mGnhHH9nbBEwzvS4eNDbgfDJ6Twvvr5_9-XyY3n1-cOny7dXpdOg57KqZds1vVfgO6e9rtqmqnXnlJLNXlvp971sat9Kq6yuZO2x6ZSTnCilXOXUefHi6Mud_ViQZjMGcsgj87wLmZapMqCWhdVR6HIiytibKYeRwRgJZmVvDmZlb1b2Zg0FXPTs5L7sR_R_S06wWfD8JLDk7NBnhhroj4696l0na9a9PuqQWdwGzIYcc3LoQ0Y3G5_C__t480-5G0IM_ON3vEM6pCVHpmykocqAuV63ZF0SaAG0rED9ApOhuPw</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Machado, Marcel C.C., MD, FACS</creator><creator>Machado, Marcel Autran C., MD</creator><creator>Bacchella, Telesforo, MD</creator><creator>Jukemura, José, MD</creator><creator>Almeida, José L., MD</creator><creator>Cunha, José E.M., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients</title><author>Machado, Marcel C.C., MD, FACS ; Machado, Marcel Autran C., MD ; Bacchella, Telesforo, MD ; Jukemura, José, MD ; Almeida, José L., MD ; Cunha, José E.M., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-241786fd30d8c5d52762458c3316b5a1dbf164d71a3a5214de683c13a5333c2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Papillary - chemistry</topic><topic>Carcinoma, Papillary - diagnosis</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Child</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Pancreatectomy</topic><topic>Pancreatic Neoplasms - chemistry</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Prognosis</topic><topic>Sex Factors</topic><topic>Surgery</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Machado, Marcel C.C., MD, FACS</creatorcontrib><creatorcontrib>Machado, Marcel Autran C., MD</creatorcontrib><creatorcontrib>Bacchella, Telesforo, MD</creatorcontrib><creatorcontrib>Jukemura, José, MD</creatorcontrib><creatorcontrib>Almeida, José L., MD</creatorcontrib><creatorcontrib>Cunha, José E.M., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machado, Marcel C.C., MD, FACS</au><au>Machado, Marcel Autran C., MD</au><au>Bacchella, Telesforo, MD</au><au>Jukemura, José, MD</au><au>Almeida, José L., MD</au><au>Cunha, José E.M., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2008</date><risdate>2008</risdate><volume>143</volume><issue>1</issue><spage>29</spage><epage>34</epage><pages>29-34</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><coden>SURGAZ</coden><abstract>Background Solid pseudopapillary neoplasm of the pancreas is a distinctive pancreatic neoplasm with low metastatic potential. This study examines clinical differences and prognosis between male and female patients. Methods The medical records of 34 consecutive patients with pancreatic solid pseudopapillary neoplasms between 1990 and 2006 were reviewed. Whenever feasible, organ-preserving operation was performed. Statistical analysis was performed using chi-square and Student t test. Results There were 27 women (79%) and seven men (21%) with median age of 23 years. Mean diameter of the tumor was 7 cm. Tumor size tended to be smaller in patients treated in more recent years. Conservative surgery was possible in 11 patients including spleen-preserving distal pancreatectomy in 3, central pancreatectomy in 5, and enucleation in 3 patients. Median hospital stay was 11 days, morbidity rate was 62%, including 17 patients with grade A pancreatic fistula, and there was no operative mortality. Mean follow-up time was 84 months. Tumor recurred in 2 patients (6%). Overall late morbidity rate was 12%. At the time of diagnosis, age was ( x ¯ ± SD) higher among male patients (25 ± 2 years vs 37 ± 7 years; P <.05) with no difference in tumor size. The neoplasms were more aggressive in male patients; therefore, conservative surgery was less likely. There was no correlation between tumor aggressiveness and age of the patient or size of tumor. Conclusion This is the first single center study to demonstrate that solid pseudopapillary neoplasms in male patients have distinct patterns of onset and aggressiveness when compared with female patients. Although valid prognostic criteria are still lacking, it appears that male patients may be best treated by more radical operation and should be observed more closely during follow-up.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>18154930</pmid><doi>10.1016/j.surg.2007.07.030</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Biomarkers, Tumor - analysis Carcinoma, Papillary - chemistry Carcinoma, Papillary - diagnosis Carcinoma, Papillary - surgery Child Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Immunohistochemistry Liver. Biliary tract. Portal circulation. Exocrine pancreas Magnetic Resonance Imaging Male Medical sciences Middle Aged Neoplasm Recurrence, Local Pancreatectomy Pancreatic Neoplasms - chemistry Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - surgery Prognosis Sex Factors Surgery Tomography, X-Ray Computed Tumors |
| title | Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients |
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