The role of dental pulp cells in resorption of deciduous teeth
Objective To address the question whether dental pulp cells of exfoliating human deciduous teeth have some roles for controlling or regulating the root resorption via secreting key molecules (OPG, RANKL, CSF-1, TGFβ, MCP-1 and Cbfa-1) in osteoclastogenesis, we used a sensitive reverse transcriptase...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2008, Vol.105 (1), p.113-120 |
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| container_title | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
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| creator | Yildirim, S., DDS, PhD Yapar, M., MD Sermet, U Sener, K., MD Kubar, A., MD |
| description | Objective To address the question whether dental pulp cells of exfoliating human deciduous teeth have some roles for controlling or regulating the root resorption via secreting key molecules (OPG, RANKL, CSF-1, TGFβ, MCP-1 and Cbfa-1) in osteoclastogenesis, we used a sensitive reverse transcriptase polymerase chain reaction (RT-PCR) method for detection of mRNA expressions for the cytokines listed. Study design The dental pulps were retrieved from incisor and molar teeth in the late stage of shedding (n = 30) and from sound premolar teeth extracted for orthodontic reasons (control group; n = 30). The RT-PCR assays were used to identify targeted gene expression. Results Of the cytokines examined, RANKL and CSF-1 expressions showed significantly higher occurrence in deciduous dental pulps than in permanent teeth pulpal tissues ( P < .040). Conclusions The findings may suggest an interactive role for pulp tissue cells in the physiologic root resorption process. The cells of dental pulp may have some cytokine-producing cells which mediate monocyte-macrophage lineage to form osteo/odontoclasts, and the RANKL/RANK system might be involved in human deciduous teeth resorption. |
| doi_str_mv | 10.1016/j.tripleo.2007.06.026 |
| format | Article |
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Study design The dental pulps were retrieved from incisor and molar teeth in the late stage of shedding (n = 30) and from sound premolar teeth extracted for orthodontic reasons (control group; n = 30). The RT-PCR assays were used to identify targeted gene expression. Results Of the cytokines examined, RANKL and CSF-1 expressions showed significantly higher occurrence in deciduous dental pulps than in permanent teeth pulpal tissues ( P < .040). Conclusions The findings may suggest an interactive role for pulp tissue cells in the physiologic root resorption process. The cells of dental pulp may have some cytokine-producing cells which mediate monocyte-macrophage lineage to form osteo/odontoclasts, and the RANKL/RANK system might be involved in human deciduous teeth resorption.</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/j.tripleo.2007.06.026</identifier><identifier>PMID: 17942342</identifier><language>eng</language><publisher>St. Louis, MO: Mosby, Inc</publisher><subject>Biological and medical sciences ; Child ; Dental Pulp - cytology ; Dental Pulp - diagnostic imaging ; Dental Pulp - secretion ; Dentistry ; DNA Primers - analysis ; Epidemiologic Methods ; Female ; Humans ; Macrophage Colony-Stimulating Factor - analysis ; Male ; Medical sciences ; Otorhinolaryngology. Stomatology ; Radiography ; RANK Ligand - analysis ; RANK Ligand - physiology ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Messenger - analysis ; Surgery ; Tooth Exfoliation - diagnostic imaging ; Tooth Exfoliation - metabolism ; Tooth Resorption - diagnostic imaging ; Tooth Resorption - metabolism ; Tooth, Deciduous - diagnostic imaging ; Tooth, Deciduous - metabolism</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2008, Vol.105 (1), p.113-120</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-dbbdf639e7a9a1792a2740ab0d264ce1cfbd16a14be98ef08e421c6ab68dd4903</citedby><cites>FETCH-LOGICAL-c448t-dbbdf639e7a9a1792a2740ab0d264ce1cfbd16a14be98ef08e421c6ab68dd4903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tripleo.2007.06.026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20049809$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17942342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yildirim, S., DDS, PhD</creatorcontrib><creatorcontrib>Yapar, M., MD</creatorcontrib><creatorcontrib>Sermet, U</creatorcontrib><creatorcontrib>Sener, K., MD</creatorcontrib><creatorcontrib>Kubar, A., MD</creatorcontrib><title>The role of dental pulp cells in resorption of deciduous teeth</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>Objective To address the question whether dental pulp cells of exfoliating human deciduous teeth have some roles for controlling or regulating the root resorption via secreting key molecules (OPG, RANKL, CSF-1, TGFβ, MCP-1 and Cbfa-1) in osteoclastogenesis, we used a sensitive reverse transcriptase polymerase chain reaction (RT-PCR) method for detection of mRNA expressions for the cytokines listed. Study design The dental pulps were retrieved from incisor and molar teeth in the late stage of shedding (n = 30) and from sound premolar teeth extracted for orthodontic reasons (control group; n = 30). The RT-PCR assays were used to identify targeted gene expression. Results Of the cytokines examined, RANKL and CSF-1 expressions showed significantly higher occurrence in deciduous dental pulps than in permanent teeth pulpal tissues ( P < .040). Conclusions The findings may suggest an interactive role for pulp tissue cells in the physiologic root resorption process. The cells of dental pulp may have some cytokine-producing cells which mediate monocyte-macrophage lineage to form osteo/odontoclasts, and the RANKL/RANK system might be involved in human deciduous teeth resorption.</description><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Dental Pulp - cytology</subject><subject>Dental Pulp - diagnostic imaging</subject><subject>Dental Pulp - secretion</subject><subject>Dentistry</subject><subject>DNA Primers - analysis</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Humans</subject><subject>Macrophage Colony-Stimulating Factor - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Radiography</subject><subject>RANK Ligand - analysis</subject><subject>RANK Ligand - physiology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Messenger - analysis</subject><subject>Surgery</subject><subject>Tooth Exfoliation - diagnostic imaging</subject><subject>Tooth Exfoliation - metabolism</subject><subject>Tooth Resorption - diagnostic imaging</subject><subject>Tooth Resorption - metabolism</subject><subject>Tooth, Deciduous - diagnostic imaging</subject><subject>Tooth, Deciduous - metabolism</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1q3TAQhUVpaX7aR2jwpt3ZHcm6srVJCCF_EMiiKXQnZGlMdKtrOZJdyNtH5poGsslKWnxzzvANId8oVBSo-LmtpuhGj6FiAE0FogImPpBDumFtWcvNn4_5D40sGQV-QI5S2gKAqKX8TA5oIzmrOTskpw-PWMTgsQh9YXGYtC_G2Y-FQe9T4YYiYgpxnFwY9ohxdg5zKibE6fEL-dRrn_Dr-h6T31eXDxc35d399e3F-V1pOG-n0nad7XM3NlrqXM40azjoDiwT3CA1fWep0JR3KFvsoUXOqBG6E621XEJ9TH7sc8cYnmZMk9q5tKyoB8zLqCYrqRljGdzsQRNDShF7NUa30_FZUVCLOLVVqzi1iFMgVBaX507WgrnboX2dWk1l4PsK6GS076MejEv_uZzFZQsyc2d7DrOOfw6jSsbhYNC6iGZSNrh3Vzl9k2C8G1wu_YvPmLZhjkN2rahKTIH6tVx5OTI0AJu6hfoFn5qjuw</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Yildirim, S., DDS, PhD</creator><creator>Yapar, M., MD</creator><creator>Sermet, U</creator><creator>Sener, K., MD</creator><creator>Kubar, A., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>The role of dental pulp cells in resorption of deciduous teeth</title><author>Yildirim, S., DDS, PhD ; Yapar, M., MD ; Sermet, U ; Sener, K., MD ; Kubar, A., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-dbbdf639e7a9a1792a2740ab0d264ce1cfbd16a14be98ef08e421c6ab68dd4903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Dental Pulp - cytology</topic><topic>Dental Pulp - diagnostic imaging</topic><topic>Dental Pulp - secretion</topic><topic>Dentistry</topic><topic>DNA Primers - analysis</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Humans</topic><topic>Macrophage Colony-Stimulating Factor - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Radiography</topic><topic>RANK Ligand - analysis</topic><topic>RANK Ligand - physiology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Messenger - analysis</topic><topic>Surgery</topic><topic>Tooth Exfoliation - diagnostic imaging</topic><topic>Tooth Exfoliation - metabolism</topic><topic>Tooth Resorption - diagnostic imaging</topic><topic>Tooth Resorption - metabolism</topic><topic>Tooth, Deciduous - diagnostic imaging</topic><topic>Tooth, Deciduous - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yildirim, S., DDS, PhD</creatorcontrib><creatorcontrib>Yapar, M., MD</creatorcontrib><creatorcontrib>Sermet, U</creatorcontrib><creatorcontrib>Sener, K., MD</creatorcontrib><creatorcontrib>Kubar, A., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yildirim, S., DDS, PhD</au><au>Yapar, M., MD</au><au>Sermet, U</au><au>Sener, K., MD</au><au>Kubar, A., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of dental pulp cells in resorption of deciduous teeth</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>2008</date><risdate>2008</risdate><volume>105</volume><issue>1</issue><spage>113</spage><epage>120</epage><pages>113-120</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Objective To address the question whether dental pulp cells of exfoliating human deciduous teeth have some roles for controlling or regulating the root resorption via secreting key molecules (OPG, RANKL, CSF-1, TGFβ, MCP-1 and Cbfa-1) in osteoclastogenesis, we used a sensitive reverse transcriptase polymerase chain reaction (RT-PCR) method for detection of mRNA expressions for the cytokines listed. Study design The dental pulps were retrieved from incisor and molar teeth in the late stage of shedding (n = 30) and from sound premolar teeth extracted for orthodontic reasons (control group; n = 30). The RT-PCR assays were used to identify targeted gene expression. Results Of the cytokines examined, RANKL and CSF-1 expressions showed significantly higher occurrence in deciduous dental pulps than in permanent teeth pulpal tissues ( P < .040). Conclusions The findings may suggest an interactive role for pulp tissue cells in the physiologic root resorption process. The cells of dental pulp may have some cytokine-producing cells which mediate monocyte-macrophage lineage to form osteo/odontoclasts, and the RANKL/RANK system might be involved in human deciduous teeth resorption.</abstract><cop>St. Louis, MO</cop><pub>Mosby, Inc</pub><pmid>17942342</pmid><doi>10.1016/j.tripleo.2007.06.026</doi><tpages>8</tpages></addata></record> |
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| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2008, Vol.105 (1), p.113-120 |
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| subjects | Biological and medical sciences Child Dental Pulp - cytology Dental Pulp - diagnostic imaging Dental Pulp - secretion Dentistry DNA Primers - analysis Epidemiologic Methods Female Humans Macrophage Colony-Stimulating Factor - analysis Male Medical sciences Otorhinolaryngology. Stomatology Radiography RANK Ligand - analysis RANK Ligand - physiology Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - analysis Surgery Tooth Exfoliation - diagnostic imaging Tooth Exfoliation - metabolism Tooth Resorption - diagnostic imaging Tooth Resorption - metabolism Tooth, Deciduous - diagnostic imaging Tooth, Deciduous - metabolism |
| title | The role of dental pulp cells in resorption of deciduous teeth |
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