ICP and CPP: excellent predictors of long term outcome in severely brain injured children
Objective To determine the predictive powers of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) amongst severely brain injured children. Materials and methods ICP and CPP were recorded from thirty-five severely brain injured children who were prospectively recruited after admission...
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| Veröffentlicht in: | Child's nervous system 2008-02, Vol.24 (2), p.245-251 |
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| creator | Carter, B. G. Butt, W. Taylor, A. |
| description | Objective
To determine the predictive powers of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) amongst severely brain injured children.
Materials and methods
ICP and CPP were recorded from thirty-five severely brain injured children who were prospectively recruited after admission to paediatric intensive care. Twenty-five suffered traumatic brain injury (TBI) and ten suffered non-TBI. Peak ICP and minimum CPP recorded for each patient during their admission were related to 5 year Glasgow Outcome Scale outcome. Receiver operator characteristic curves determined that the optimum threshold for unfavourable outcome prediction was ≥40 mmHg for ICP and ≤49 mmHg for CPP. At these thresholds the sensitivity/specificity pairs for the prediction of unfavourable outcome were 33.3/100% and 55.6/100% for ICP and CPP, respectively, amongst patients suffering TBI and were 46.2/100% and 66.2/100% for ICP and CPP, respectively, amongst all patients.
Conclusion
ICP and CPP are accurate predictors of unfavourable outcome. |
| doi_str_mv | 10.1007/s00381-007-0461-z |
| format | Article |
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To determine the predictive powers of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) amongst severely brain injured children.
Materials and methods
ICP and CPP were recorded from thirty-five severely brain injured children who were prospectively recruited after admission to paediatric intensive care. Twenty-five suffered traumatic brain injury (TBI) and ten suffered non-TBI. Peak ICP and minimum CPP recorded for each patient during their admission were related to 5 year Glasgow Outcome Scale outcome. Receiver operator characteristic curves determined that the optimum threshold for unfavourable outcome prediction was ≥40 mmHg for ICP and ≤49 mmHg for CPP. At these thresholds the sensitivity/specificity pairs for the prediction of unfavourable outcome were 33.3/100% and 55.6/100% for ICP and CPP, respectively, amongst patients suffering TBI and were 46.2/100% and 66.2/100% for ICP and CPP, respectively, amongst all patients.
Conclusion
ICP and CPP are accurate predictors of unfavourable outcome.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-007-0461-z</identifier><identifier>PMID: 17712566</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Brain Injuries - mortality ; Brain Injuries - physiopathology ; Cerebrovascular Circulation - physiology ; Child ; Child, Preschool ; Glasgow Outcome Scale ; Humans ; Infant ; Intracranial Pressure - physiology ; Medicine ; Medicine & Public Health ; Neurosciences ; Neurosurgery ; Original Paper ; Prognosis ; ROC Curve ; Sensitivity and Specificity</subject><ispartof>Child's nervous system, 2008-02, Vol.24 (2), p.245-251</ispartof><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-df1f6fde60e559d5dea5a39bd7f7895bae46412038ec1b60bc2521b3764636933</citedby><cites>FETCH-LOGICAL-c342t-df1f6fde60e559d5dea5a39bd7f7895bae46412038ec1b60bc2521b3764636933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00381-007-0461-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00381-007-0461-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17712566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carter, B. G.</creatorcontrib><creatorcontrib>Butt, W.</creatorcontrib><creatorcontrib>Taylor, A.</creatorcontrib><title>ICP and CPP: excellent predictors of long term outcome in severely brain injured children</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Objective
To determine the predictive powers of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) amongst severely brain injured children.
Materials and methods
ICP and CPP were recorded from thirty-five severely brain injured children who were prospectively recruited after admission to paediatric intensive care. Twenty-five suffered traumatic brain injury (TBI) and ten suffered non-TBI. Peak ICP and minimum CPP recorded for each patient during their admission were related to 5 year Glasgow Outcome Scale outcome. Receiver operator characteristic curves determined that the optimum threshold for unfavourable outcome prediction was ≥40 mmHg for ICP and ≤49 mmHg for CPP. At these thresholds the sensitivity/specificity pairs for the prediction of unfavourable outcome were 33.3/100% and 55.6/100% for ICP and CPP, respectively, amongst patients suffering TBI and were 46.2/100% and 66.2/100% for ICP and CPP, respectively, amongst all patients.
Conclusion
ICP and CPP are accurate predictors of unfavourable outcome.</description><subject>Adolescent</subject><subject>Brain Injuries - mortality</subject><subject>Brain Injuries - physiopathology</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Glasgow Outcome Scale</subject><subject>Humans</subject><subject>Infant</subject><subject>Intracranial Pressure - physiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Paper</subject><subject>Prognosis</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ULtOwzAUtRCIlsIHsCBPbIHrOHYSNlTxkirRAQYmK4lvSqrELnaCaL8eR63ExnTP1XlI5xByyeCGAaS3HoBnLAowgkSyaHdEpizhPAIu4JhMIRYySiGBCTnzfg3ARBbnp2TC0pQFTk7Jx8t8SQuj6Xy5vKP4U2HbounpxqFuqt46T21NW2tWtEfXUTv0le2QNoZ6_EaH7ZaWrghvY9ZDMNHqs2m1Q3NOTuqi9XhxuDPy_vjwNn-OFq9PL_P7RVTxJO4jXbNa1holoBC5FhoLUfC81GmdZrkoC0xkwuJQFCtWSiirWMSs5KlMJJc55zNyvc_dOPs1oO9V1_ixRmHQDl6lwGTMeRaEbC-snPXeYa02rukKt1UM1Lin2u-pRjjuqXbBc3UIH8oO9Z_jMGAQxHuBD5RZoVNrOzgTCv-T-guaXIDF</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Carter, B. G.</creator><creator>Butt, W.</creator><creator>Taylor, A.</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080201</creationdate><title>ICP and CPP: excellent predictors of long term outcome in severely brain injured children</title><author>Carter, B. G. ; Butt, W. ; Taylor, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-df1f6fde60e559d5dea5a39bd7f7895bae46412038ec1b60bc2521b3764636933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Brain Injuries - mortality</topic><topic>Brain Injuries - physiopathology</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Glasgow Outcome Scale</topic><topic>Humans</topic><topic>Infant</topic><topic>Intracranial Pressure - physiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Paper</topic><topic>Prognosis</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carter, B. G.</creatorcontrib><creatorcontrib>Butt, W.</creatorcontrib><creatorcontrib>Taylor, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carter, B. G.</au><au>Butt, W.</au><au>Taylor, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ICP and CPP: excellent predictors of long term outcome in severely brain injured children</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><addtitle>Childs Nerv Syst</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>24</volume><issue>2</issue><spage>245</spage><epage>251</epage><pages>245-251</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Objective
To determine the predictive powers of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) amongst severely brain injured children.
Materials and methods
ICP and CPP were recorded from thirty-five severely brain injured children who were prospectively recruited after admission to paediatric intensive care. Twenty-five suffered traumatic brain injury (TBI) and ten suffered non-TBI. Peak ICP and minimum CPP recorded for each patient during their admission were related to 5 year Glasgow Outcome Scale outcome. Receiver operator characteristic curves determined that the optimum threshold for unfavourable outcome prediction was ≥40 mmHg for ICP and ≤49 mmHg for CPP. At these thresholds the sensitivity/specificity pairs for the prediction of unfavourable outcome were 33.3/100% and 55.6/100% for ICP and CPP, respectively, amongst patients suffering TBI and were 46.2/100% and 66.2/100% for ICP and CPP, respectively, amongst all patients.
Conclusion
ICP and CPP are accurate predictors of unfavourable outcome.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>17712566</pmid><doi>10.1007/s00381-007-0461-z</doi><tpages>7</tpages></addata></record> |
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| ispartof | Child's nervous system, 2008-02, Vol.24 (2), p.245-251 |
| issn | 0256-7040 1433-0350 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Brain Injuries - mortality Brain Injuries - physiopathology Cerebrovascular Circulation - physiology Child Child, Preschool Glasgow Outcome Scale Humans Infant Intracranial Pressure - physiology Medicine Medicine & Public Health Neurosciences Neurosurgery Original Paper Prognosis ROC Curve Sensitivity and Specificity |
| title | ICP and CPP: excellent predictors of long term outcome in severely brain injured children |
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