Rotavirus vaccination for Hong Kong children: an economic evaluation from the Hong Kong Government perspective
Aims:To perform an economic analysis of government-funded universal rotavirus vaccination in Hong Kong from the government’s perspective.Methods:A Markov model of costs and effects (disability averted) associated with universal vaccination was compared with no vaccination. In both strategies, newbor...
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| Veröffentlicht in: | Archives of disease in childhood 2008-01, Vol.93 (1), p.52-58 |
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| creator | Ho, A M-H Nelson, E A S Walker, D G |
| description | Aims:To perform an economic analysis of government-funded universal rotavirus vaccination in Hong Kong from the government’s perspective.Methods:A Markov model of costs and effects (disability averted) associated with universal vaccination was compared with no vaccination. In both strategies, newborns were studied until 5 years of age or until they died, using cost, probability and utility data from the literature. The potential cost savings and cost effectiveness of vaccination were calculated and their sensitivities to changes in vaccine and health care costs, presumed decline in vaccine efficacy over time, and the use of discounting and age weights were determined.Results:Depending on assumptions, the new rotavirus vaccines would be cost saving to the Hong Kong Government if they cost less than US$40–92 per course. Higher vaccine costs would quickly lead to an incremental cost-effectiveness ratio exceeding that of the gross national product per capita if the mortality rate of rotavirus gastroenteritis remained at zero.Conclusions:Based on 2002 demographic, cost and morbidity data and reasonable uncertainty estimates of these variables, a universal rotavirus vaccination programme paid for by the Hong Kong Government is cost neutral at a per course vaccine cost of US$40–92. For a fixed vaccine cost, the potential savings and cost effectiveness of the vaccine increase with higher estimated health care costs and vice versa. |
| doi_str_mv | 10.1136/adc.2007.117879 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_70160000</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A174621774</galeid><sourcerecordid>A174621774</sourcerecordid><originalsourceid>FETCH-LOGICAL-b495t-cf7b0a81fd94d1dc2843a20f51d4f1992c79a7324dbfc6238d932da2ce785c2a3</originalsourceid><addsrcrecordid>eNqF0c-L1DAUB_Agijuunr1JQfQgdDe_2iTe1q7uiKsLi3oNaZLOZmyTMWkH_e_N0OKIlyWQUPJJee99AXiO4BlCpD5XRp9hCFn-YpyJB2CFaM1LDCl9CFYQQlIKzvkJeJLSFkKEOSePwUnGVUUJXwF_G0a1d3FKxV5p7bwaXfBFF2KxDn5TfDps-s71Jlr_tlC-sDr4MDhd2L3qp4XHMBTjnf3nzVXY2-gH68diZ2PaWT26vX0KHnWqT_bZcp6Cbx_ef23W5fXN1cfm4rpsqajGUneshYqjzghqkNGYU6Iw7CpkaIeEwJoJxQimpu10jQk3gmCjsLa5MY0VOQWv5__uYvg52TTKwSVt-155G6YkGUQ1PIznPpgnWVV1JTJ8-R_chin63IREHOcFKUdZlbPaqN5K5_OsRvtr1KHv7cbK3GNzIy8QozVGjNHsz2evY0gp2k7uohtU_C0RlIeEZU5YHhKWc8L5xYuljqkdrDn6JdIMXi1AJa36LiqvXTo6ISCjkB1LdSmX-PdexR-yZoRV8sv3Rr77zOrby-ZSrrN_M_t22N5b5R9TH8nB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1828280481</pqid></control><display><type>article</type><title>Rotavirus vaccination for Hong Kong children: an economic evaluation from the Hong Kong Government perspective</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Ho, A M-H ; Nelson, E A S ; Walker, D G</creator><creatorcontrib>Ho, A M-H ; Nelson, E A S ; Walker, D G</creatorcontrib><description>Aims:To perform an economic analysis of government-funded universal rotavirus vaccination in Hong Kong from the government’s perspective.Methods:A Markov model of costs and effects (disability averted) associated with universal vaccination was compared with no vaccination. In both strategies, newborns were studied until 5 years of age or until they died, using cost, probability and utility data from the literature. The potential cost savings and cost effectiveness of vaccination were calculated and their sensitivities to changes in vaccine and health care costs, presumed decline in vaccine efficacy over time, and the use of discounting and age weights were determined.Results:Depending on assumptions, the new rotavirus vaccines would be cost saving to the Hong Kong Government if they cost less than US$40–92 per course. Higher vaccine costs would quickly lead to an incremental cost-effectiveness ratio exceeding that of the gross national product per capita if the mortality rate of rotavirus gastroenteritis remained at zero.Conclusions:Based on 2002 demographic, cost and morbidity data and reasonable uncertainty estimates of these variables, a universal rotavirus vaccination programme paid for by the Hong Kong Government is cost neutral at a per course vaccine cost of US$40–92. For a fixed vaccine cost, the potential savings and cost effectiveness of the vaccine increase with higher estimated health care costs and vice versa.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.2007.117879</identifier><identifier>PMID: 17855438</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Age ; Biological and medical sciences ; Cost control ; Cost Effectiveness ; Cost-Benefit Analysis ; Decision Trees ; Discount rates ; Dosage and administration ; Economic analysis ; Economic aspects ; Economics ; Gastroenteritis ; Gastroenteritis - prevention & control ; Gastroenteritis - virology ; General aspects ; Government (Administrative Body) ; Health care ; Health care costs ; Hong Kong ; Humans ; Illnesses ; Immunization ; Immunization Programs - economics ; Infant ; Infant, Newborn ; Intestinal obstruction ; Markov Chains ; Markov Processes ; Medical care, Cost of ; Medical sciences ; Miscellaneous ; Models, Econometric ; Monte Carlo Method ; Monte Carlo Methods ; Monte Carlo simulation ; Population Trends ; Present value ; Prevention ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Quality-Adjusted Life Years ; Rotavirus ; Rotavirus infections ; Rotavirus Vaccines - economics ; Statistical Data ; Surveillance ; Vaccines ; Viral vaccines ; Viruses ; Young Children</subject><ispartof>Archives of disease in childhood, 2008-01, Vol.93 (1), p.52-58</ispartof><rights>2008 BMJ Publishing Group and Royal College of Paediatrics and Child Health</rights><rights>2008 INIST-CNRS</rights><rights>Copyright: 2008 2008 BMJ Publishing Group and Royal College of Paediatrics and Child Health</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b495t-cf7b0a81fd94d1dc2843a20f51d4f1992c79a7324dbfc6238d932da2ce785c2a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://adc.bmj.com/content/93/1/52.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://adc.bmj.com/content/93/1/52.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,4024,23571,27923,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19907407$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17855438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ho, A M-H</creatorcontrib><creatorcontrib>Nelson, E A S</creatorcontrib><creatorcontrib>Walker, D G</creatorcontrib><title>Rotavirus vaccination for Hong Kong children: an economic evaluation from the Hong Kong Government perspective</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Aims:To perform an economic analysis of government-funded universal rotavirus vaccination in Hong Kong from the government’s perspective.Methods:A Markov model of costs and effects (disability averted) associated with universal vaccination was compared with no vaccination. In both strategies, newborns were studied until 5 years of age or until they died, using cost, probability and utility data from the literature. The potential cost savings and cost effectiveness of vaccination were calculated and their sensitivities to changes in vaccine and health care costs, presumed decline in vaccine efficacy over time, and the use of discounting and age weights were determined.Results:Depending on assumptions, the new rotavirus vaccines would be cost saving to the Hong Kong Government if they cost less than US$40–92 per course. Higher vaccine costs would quickly lead to an incremental cost-effectiveness ratio exceeding that of the gross national product per capita if the mortality rate of rotavirus gastroenteritis remained at zero.Conclusions:Based on 2002 demographic, cost and morbidity data and reasonable uncertainty estimates of these variables, a universal rotavirus vaccination programme paid for by the Hong Kong Government is cost neutral at a per course vaccine cost of US$40–92. For a fixed vaccine cost, the potential savings and cost effectiveness of the vaccine increase with higher estimated health care costs and vice versa.</description><subject>Age</subject><subject>Biological and medical sciences</subject><subject>Cost control</subject><subject>Cost Effectiveness</subject><subject>Cost-Benefit Analysis</subject><subject>Decision Trees</subject><subject>Discount rates</subject><subject>Dosage and administration</subject><subject>Economic analysis</subject><subject>Economic aspects</subject><subject>Economics</subject><subject>Gastroenteritis</subject><subject>Gastroenteritis - prevention & control</subject><subject>Gastroenteritis - virology</subject><subject>General aspects</subject><subject>Government (Administrative Body)</subject><subject>Health care</subject><subject>Health care costs</subject><subject>Hong Kong</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Immunization</subject><subject>Immunization Programs - economics</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Intestinal obstruction</subject><subject>Markov Chains</subject><subject>Markov Processes</subject><subject>Medical care, Cost of</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Models, Econometric</subject><subject>Monte Carlo Method</subject><subject>Monte Carlo Methods</subject><subject>Monte Carlo simulation</subject><subject>Population Trends</subject><subject>Present value</subject><subject>Prevention</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Quality-Adjusted Life Years</subject><subject>Rotavirus</subject><subject>Rotavirus infections</subject><subject>Rotavirus Vaccines - economics</subject><subject>Statistical Data</subject><subject>Surveillance</subject><subject>Vaccines</subject><subject>Viral vaccines</subject><subject>Viruses</subject><subject>Young Children</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0c-L1DAUB_Agijuunr1JQfQgdDe_2iTe1q7uiKsLi3oNaZLOZmyTMWkH_e_N0OKIlyWQUPJJee99AXiO4BlCpD5XRp9hCFn-YpyJB2CFaM1LDCl9CFYQQlIKzvkJeJLSFkKEOSePwUnGVUUJXwF_G0a1d3FKxV5p7bwaXfBFF2KxDn5TfDps-s71Jlr_tlC-sDr4MDhd2L3qp4XHMBTjnf3nzVXY2-gH68diZ2PaWT26vX0KHnWqT_bZcp6Cbx_ef23W5fXN1cfm4rpsqajGUneshYqjzghqkNGYU6Iw7CpkaIeEwJoJxQimpu10jQk3gmCjsLa5MY0VOQWv5__uYvg52TTKwSVt-155G6YkGUQ1PIznPpgnWVV1JTJ8-R_chin63IREHOcFKUdZlbPaqN5K5_OsRvtr1KHv7cbK3GNzIy8QozVGjNHsz2evY0gp2k7uohtU_C0RlIeEZU5YHhKWc8L5xYuljqkdrDn6JdIMXi1AJa36LiqvXTo6ISCjkB1LdSmX-PdexR-yZoRV8sv3Rr77zOrby-ZSrrN_M_t22N5b5R9TH8nB</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Ho, A M-H</creator><creator>Nelson, E A S</creator><creator>Walker, D G</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200801</creationdate><title>Rotavirus vaccination for Hong Kong children: an economic evaluation from the Hong Kong Government perspective</title><author>Ho, A M-H ; Nelson, E A S ; Walker, D G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b495t-cf7b0a81fd94d1dc2843a20f51d4f1992c79a7324dbfc6238d932da2ce785c2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Age</topic><topic>Biological and medical sciences</topic><topic>Cost control</topic><topic>Cost Effectiveness</topic><topic>Cost-Benefit Analysis</topic><topic>Decision Trees</topic><topic>Discount rates</topic><topic>Dosage and administration</topic><topic>Economic analysis</topic><topic>Economic aspects</topic><topic>Economics</topic><topic>Gastroenteritis</topic><topic>Gastroenteritis - prevention & control</topic><topic>Gastroenteritis - virology</topic><topic>General aspects</topic><topic>Government (Administrative Body)</topic><topic>Health care</topic><topic>Health care costs</topic><topic>Hong Kong</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Immunization</topic><topic>Immunization Programs - economics</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Intestinal obstruction</topic><topic>Markov Chains</topic><topic>Markov Processes</topic><topic>Medical care, Cost of</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Models, Econometric</topic><topic>Monte Carlo Method</topic><topic>Monte Carlo Methods</topic><topic>Monte Carlo simulation</topic><topic>Population Trends</topic><topic>Present value</topic><topic>Prevention</topic><topic>Prevention and actions</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Quality-Adjusted Life Years</topic><topic>Rotavirus</topic><topic>Rotavirus infections</topic><topic>Rotavirus Vaccines - economics</topic><topic>Statistical Data</topic><topic>Surveillance</topic><topic>Vaccines</topic><topic>Viral vaccines</topic><topic>Viruses</topic><topic>Young Children</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ho, A M-H</creatorcontrib><creatorcontrib>Nelson, E A S</creatorcontrib><creatorcontrib>Walker, D G</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ho, A M-H</au><au>Nelson, E A S</au><au>Walker, D G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rotavirus vaccination for Hong Kong children: an economic evaluation from the Hong Kong Government perspective</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>2008-01</date><risdate>2008</risdate><volume>93</volume><issue>1</issue><spage>52</spage><epage>58</epage><pages>52-58</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>Aims:To perform an economic analysis of government-funded universal rotavirus vaccination in Hong Kong from the government’s perspective.Methods:A Markov model of costs and effects (disability averted) associated with universal vaccination was compared with no vaccination. In both strategies, newborns were studied until 5 years of age or until they died, using cost, probability and utility data from the literature. The potential cost savings and cost effectiveness of vaccination were calculated and their sensitivities to changes in vaccine and health care costs, presumed decline in vaccine efficacy over time, and the use of discounting and age weights were determined.Results:Depending on assumptions, the new rotavirus vaccines would be cost saving to the Hong Kong Government if they cost less than US$40–92 per course. Higher vaccine costs would quickly lead to an incremental cost-effectiveness ratio exceeding that of the gross national product per capita if the mortality rate of rotavirus gastroenteritis remained at zero.Conclusions:Based on 2002 demographic, cost and morbidity data and reasonable uncertainty estimates of these variables, a universal rotavirus vaccination programme paid for by the Hong Kong Government is cost neutral at a per course vaccine cost of US$40–92. For a fixed vaccine cost, the potential savings and cost effectiveness of the vaccine increase with higher estimated health care costs and vice versa.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>17855438</pmid><doi>10.1136/adc.2007.117879</doi><tpages>7</tpages></addata></record> |
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| ispartof | Archives of disease in childhood, 2008-01, Vol.93 (1), p.52-58 |
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| subjects | Age Biological and medical sciences Cost control Cost Effectiveness Cost-Benefit Analysis Decision Trees Discount rates Dosage and administration Economic analysis Economic aspects Economics Gastroenteritis Gastroenteritis - prevention & control Gastroenteritis - virology General aspects Government (Administrative Body) Health care Health care costs Hong Kong Humans Illnesses Immunization Immunization Programs - economics Infant Infant, Newborn Intestinal obstruction Markov Chains Markov Processes Medical care, Cost of Medical sciences Miscellaneous Models, Econometric Monte Carlo Method Monte Carlo Methods Monte Carlo simulation Population Trends Present value Prevention Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Quality-Adjusted Life Years Rotavirus Rotavirus infections Rotavirus Vaccines - economics Statistical Data Surveillance Vaccines Viral vaccines Viruses Young Children |
| title | Rotavirus vaccination for Hong Kong children: an economic evaluation from the Hong Kong Government perspective |
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