Modulation of the Conductance-Voltage Relationship of the BK Ca Channel by Mutations at the Putative Flexible Interface between Two RCK Domains

Calcium-dependent gating of the large-conductance Ca 2+-activated K + (BK Ca) channel is conferred by the large cytosolic carboxyl terminus containing two domains of the regulator of K + conductance (RCK) and the high-affinity Ca 2+-binding site (the Ca 2+-bowl). In our previous study, we located th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biophysical journal 2008-01, Vol.94 (2), p.446-456
Hauptverfasser:	Kim, Hyun-Ju, Lim, Hyun-Ho, Rho, Seong-Hwan, Bao, Lin, Lee, Ju-Ho, Cox, Daniel H., Kim, Do Han, Park, Chul-Seung
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Aspartic Acid - genetics Calcium - pharmacology CHO Cells Cricetinae Cricetulus Electric Conductivity Glycine - genetics Ion Channel Gating - drug effects Large-Conductance Calcium-Activated Potassium Channels - chemistry Large-Conductance Calcium-Activated Potassium Channels - metabolism Models, Biological Mutant Proteins - metabolism Mutation - genetics Protein Structure, Tertiary Rats Structure-Activity Relationship Xenopus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!