Suppression of host Th1-type granulomatous inflammation by Taenia solium metacestodes is related to down-regulation of osteopontin gene expression
Inflammation and granuloma formation in human neurocysticercosis has been attributed to Th1-type immune responses of the host. In the present murine model, over 94% of Taenia solium metacestodes were viable and elicited no granulomatous inflammation, whereas parasites killed by praziquantel treatmen...
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| Veröffentlicht in: | International journal for parasitology 2008-02, Vol.38 (2), p.239-248 |
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| creator | Wang, I-Chuang Fan, Ping-Chin Lu, Sen-Chi Fan, Chia-Kwung Su, Kua-Eyre |
| description | Inflammation and granuloma formation in human neurocysticercosis has been attributed to Th1-type immune responses of the host. In the present murine model, over 94% of
Taenia solium metacestodes were viable and elicited no granulomatous inflammation, whereas parasites killed by praziquantel treatment elicited rapid granuloma formation that calcified within 2
weeks. Osteopontin (OPN) is a Th1-related cytokine that is up-stream of IL-12 and which may play an essential role in granuloma formation and calcification. OPN mRNA expression was down-regulated in tissues surrounding viable cysticerci, but was up-regulated in inflammatory tissues surrounding degenerating cysticerci. Moreover, co-culture with a viable cysticercus or ES products from these metacestodes led to a decrease in OPN, IFN-γ and IL-12 expression, whereas co-culture with somatic proteins enhanced OPN expression by leukocytes. Addition of recombinant mouse OPN (rmOPN) counteracted the down-regulation of IL-12 and IFN-γ mRNA expression, but not OPN mRNA expression, in leukocyte cultures. Furthermore, injection of rmOPN into the tissues surrounding implanted cysticerci enhanced inflammatory responses while a similar injection of an anti-rmOPN antibody reduced inflammation. These findings suggest that the suppression of host Th1-type granulomatous inflammation by ES products from
T. solium metacestodes is related to down-regulation of OPN gene expression. |
| doi_str_mv | 10.1016/j.ijpara.2007.07.010 |
| format | Article |
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Taenia solium metacestodes were viable and elicited no granulomatous inflammation, whereas parasites killed by praziquantel treatment elicited rapid granuloma formation that calcified within 2
weeks. Osteopontin (OPN) is a Th1-related cytokine that is up-stream of IL-12 and which may play an essential role in granuloma formation and calcification. OPN mRNA expression was down-regulated in tissues surrounding viable cysticerci, but was up-regulated in inflammatory tissues surrounding degenerating cysticerci. Moreover, co-culture with a viable cysticercus or ES products from these metacestodes led to a decrease in OPN, IFN-γ and IL-12 expression, whereas co-culture with somatic proteins enhanced OPN expression by leukocytes. Addition of recombinant mouse OPN (rmOPN) counteracted the down-regulation of IL-12 and IFN-γ mRNA expression, but not OPN mRNA expression, in leukocyte cultures. Furthermore, injection of rmOPN into the tissues surrounding implanted cysticerci enhanced inflammatory responses while a similar injection of an anti-rmOPN antibody reduced inflammation. These findings suggest that the suppression of host Th1-type granulomatous inflammation by ES products from
T. solium metacestodes is related to down-regulation of OPN gene expression.</description><identifier>ISSN: 0020-7519</identifier><identifier>EISSN: 1879-0135</identifier><identifier>DOI: 10.1016/j.ijpara.2007.07.010</identifier><identifier>PMID: 17765901</identifier><identifier>CODEN: IJPYBT</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>animal disease models ; Animals ; Biological and medical sciences ; Cysticercosis ; Cysticercus - immunology ; cytokines ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Gene Expression Regulation ; granuloma ; Granulomatous inflammation ; host immunosuppression ; Host-Parasite Interactions ; Humans ; IFN-γ ; IL-12 ; immune response ; Immunosuppression ; immunosuppression (physiological) ; inflammation ; Interferon-gamma - genetics ; interferons ; interleukin-12 ; Interleukin-12 - genetics ; Life cycle. Host-agent relationship. Pathogenesis ; messenger RNA ; metacestodes ; Mice ; Mice, Inbred Strains ; neurocysticercosis ; OPN ; osteopontin ; Osteopontin - genetics ; Osteopontin - metabolism ; Protozoa ; Taenia ; Taenia solium ; Taenia solium - physiology ; Taeniasis - immunology ; Th1 Cells - immunology ; Th1-type immune response ; Th1-type responses</subject><ispartof>International journal for parasitology, 2008-02, Vol.38 (2), p.239-248</ispartof><rights>2007 Australian Society for Parasitology Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-9cd3ac6956d9d3f198ef48d926a4a58ada3961b807cff655fa9c477bb4f83ef73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpara.2007.07.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19988900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17765901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, I-Chuang</creatorcontrib><creatorcontrib>Fan, Ping-Chin</creatorcontrib><creatorcontrib>Lu, Sen-Chi</creatorcontrib><creatorcontrib>Fan, Chia-Kwung</creatorcontrib><creatorcontrib>Su, Kua-Eyre</creatorcontrib><title>Suppression of host Th1-type granulomatous inflammation by Taenia solium metacestodes is related to down-regulation of osteopontin gene expression</title><title>International journal for parasitology</title><addtitle>Int J Parasitol</addtitle><description>Inflammation and granuloma formation in human neurocysticercosis has been attributed to Th1-type immune responses of the host. In the present murine model, over 94% of
Taenia solium metacestodes were viable and elicited no granulomatous inflammation, whereas parasites killed by praziquantel treatment elicited rapid granuloma formation that calcified within 2
weeks. Osteopontin (OPN) is a Th1-related cytokine that is up-stream of IL-12 and which may play an essential role in granuloma formation and calcification. OPN mRNA expression was down-regulated in tissues surrounding viable cysticerci, but was up-regulated in inflammatory tissues surrounding degenerating cysticerci. Moreover, co-culture with a viable cysticercus or ES products from these metacestodes led to a decrease in OPN, IFN-γ and IL-12 expression, whereas co-culture with somatic proteins enhanced OPN expression by leukocytes. Addition of recombinant mouse OPN (rmOPN) counteracted the down-regulation of IL-12 and IFN-γ mRNA expression, but not OPN mRNA expression, in leukocyte cultures. Furthermore, injection of rmOPN into the tissues surrounding implanted cysticerci enhanced inflammatory responses while a similar injection of an anti-rmOPN antibody reduced inflammation. These findings suggest that the suppression of host Th1-type granulomatous inflammation by ES products from
T. solium metacestodes is related to down-regulation of OPN gene expression.</description><subject>animal disease models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cysticercosis</subject><subject>Cysticercus - immunology</subject><subject>cytokines</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Gene Expression Regulation</subject><subject>granuloma</subject><subject>Granulomatous inflammation</subject><subject>host immunosuppression</subject><subject>Host-Parasite Interactions</subject><subject>Humans</subject><subject>IFN-γ</subject><subject>IL-12</subject><subject>immune response</subject><subject>Immunosuppression</subject><subject>immunosuppression (physiological)</subject><subject>inflammation</subject><subject>Interferon-gamma - genetics</subject><subject>interferons</subject><subject>interleukin-12</subject><subject>Interleukin-12 - genetics</subject><subject>Life cycle. Host-agent relationship. Pathogenesis</subject><subject>messenger RNA</subject><subject>metacestodes</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>neurocysticercosis</subject><subject>OPN</subject><subject>osteopontin</subject><subject>Osteopontin - genetics</subject><subject>Osteopontin - metabolism</subject><subject>Protozoa</subject><subject>Taenia</subject><subject>Taenia solium</subject><subject>Taenia solium - physiology</subject><subject>Taeniasis - immunology</subject><subject>Th1 Cells - immunology</subject><subject>Th1-type immune response</subject><subject>Th1-type responses</subject><issn>0020-7519</issn><issn>1879-0135</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-KFDEQxhtR3HX1DURz0VuPyXTSSS6CLP6DBQ87ew41SWU2Q3enTbrVeQ2f2DQ9sjeFghD41Vdf1VdVLxndMMrad8dNOI6QYLOlVG6WYvRRdcmU1DVljXhcXVK6pbUUTF9Uz3I-UspEw_nT6oJJ2QpN2WX1-3Yex4Q5hziQ6Ml9zBPZ3bN6Oo1IDgmGuYs9THHOJAy-g758FnZ_IjvAIQDJsQtzT3qcwGKeosOCZpKwgwkdmSJx8edQJzzM3dpb5pQxGMc4TGEgBxyQ4K-_Np5XTzx0GV-c36vq7tPH3fWX-ubb56_XH25qy7mYam1dA7bVonXaNZ5phZ4rp7ctcBAKHDS6ZXtFpfW-FcKDtlzK_Z571aCXzVX1dtUdU_w-F-emD9li18GAZV0jy7mUou1_QaYlbbngBeQraFPMOaE3Ywo9pJNh1CyhmaNZQzNLaGYpRkvbq7P-vO_RPTSdUyrAmzMA2ULnSyo25AdOa6U0XYRer5yHaOCQCnN3uy0ClCoumVhWeb8SWA77I2Ay2QYcLLqQ0E7GxfBvr38AG3nEpw</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Wang, I-Chuang</creator><creator>Fan, Ping-Chin</creator><creator>Lu, Sen-Chi</creator><creator>Fan, Chia-Kwung</creator><creator>Su, Kua-Eyre</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080201</creationdate><title>Suppression of host Th1-type granulomatous inflammation by Taenia solium metacestodes is related to down-regulation of osteopontin gene expression</title><author>Wang, I-Chuang ; Fan, Ping-Chin ; Lu, Sen-Chi ; Fan, Chia-Kwung ; Su, Kua-Eyre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-9cd3ac6956d9d3f198ef48d926a4a58ada3961b807cff655fa9c477bb4f83ef73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal disease models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cysticercosis</topic><topic>Cysticercus - immunology</topic><topic>cytokines</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Gene Expression Regulation</topic><topic>granuloma</topic><topic>Granulomatous inflammation</topic><topic>host immunosuppression</topic><topic>Host-Parasite Interactions</topic><topic>Humans</topic><topic>IFN-γ</topic><topic>IL-12</topic><topic>immune response</topic><topic>Immunosuppression</topic><topic>immunosuppression (physiological)</topic><topic>inflammation</topic><topic>Interferon-gamma - genetics</topic><topic>interferons</topic><topic>interleukin-12</topic><topic>Interleukin-12 - genetics</topic><topic>Life cycle. Host-agent relationship. Pathogenesis</topic><topic>messenger RNA</topic><topic>metacestodes</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>neurocysticercosis</topic><topic>OPN</topic><topic>osteopontin</topic><topic>Osteopontin - genetics</topic><topic>Osteopontin - metabolism</topic><topic>Protozoa</topic><topic>Taenia</topic><topic>Taenia solium</topic><topic>Taenia solium - physiology</topic><topic>Taeniasis - immunology</topic><topic>Th1 Cells - immunology</topic><topic>Th1-type immune response</topic><topic>Th1-type responses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, I-Chuang</creatorcontrib><creatorcontrib>Fan, Ping-Chin</creatorcontrib><creatorcontrib>Lu, Sen-Chi</creatorcontrib><creatorcontrib>Fan, Chia-Kwung</creatorcontrib><creatorcontrib>Su, Kua-Eyre</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, I-Chuang</au><au>Fan, Ping-Chin</au><au>Lu, Sen-Chi</au><au>Fan, Chia-Kwung</au><au>Su, Kua-Eyre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of host Th1-type granulomatous inflammation by Taenia solium metacestodes is related to down-regulation of osteopontin gene expression</atitle><jtitle>International journal for parasitology</jtitle><addtitle>Int J Parasitol</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>38</volume><issue>2</issue><spage>239</spage><epage>248</epage><pages>239-248</pages><issn>0020-7519</issn><eissn>1879-0135</eissn><coden>IJPYBT</coden><abstract>Inflammation and granuloma formation in human neurocysticercosis has been attributed to Th1-type immune responses of the host. In the present murine model, over 94% of
Taenia solium metacestodes were viable and elicited no granulomatous inflammation, whereas parasites killed by praziquantel treatment elicited rapid granuloma formation that calcified within 2
weeks. Osteopontin (OPN) is a Th1-related cytokine that is up-stream of IL-12 and which may play an essential role in granuloma formation and calcification. OPN mRNA expression was down-regulated in tissues surrounding viable cysticerci, but was up-regulated in inflammatory tissues surrounding degenerating cysticerci. Moreover, co-culture with a viable cysticercus or ES products from these metacestodes led to a decrease in OPN, IFN-γ and IL-12 expression, whereas co-culture with somatic proteins enhanced OPN expression by leukocytes. Addition of recombinant mouse OPN (rmOPN) counteracted the down-regulation of IL-12 and IFN-γ mRNA expression, but not OPN mRNA expression, in leukocyte cultures. Furthermore, injection of rmOPN into the tissues surrounding implanted cysticerci enhanced inflammatory responses while a similar injection of an anti-rmOPN antibody reduced inflammation. These findings suggest that the suppression of host Th1-type granulomatous inflammation by ES products from
T. solium metacestodes is related to down-regulation of OPN gene expression.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17765901</pmid><doi>10.1016/j.ijpara.2007.07.010</doi><tpages>10</tpages></addata></record> |
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| ispartof | International journal for parasitology, 2008-02, Vol.38 (2), p.239-248 |
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| subjects | animal disease models Animals Biological and medical sciences Cysticercosis Cysticercus - immunology cytokines Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Expression Regulation granuloma Granulomatous inflammation host immunosuppression Host-Parasite Interactions Humans IFN-γ IL-12 immune response Immunosuppression immunosuppression (physiological) inflammation Interferon-gamma - genetics interferons interleukin-12 Interleukin-12 - genetics Life cycle. Host-agent relationship. Pathogenesis messenger RNA metacestodes Mice Mice, Inbred Strains neurocysticercosis OPN osteopontin Osteopontin - genetics Osteopontin - metabolism Protozoa Taenia Taenia solium Taenia solium - physiology Taeniasis - immunology Th1 Cells - immunology Th1-type immune response Th1-type responses |
| title | Suppression of host Th1-type granulomatous inflammation by Taenia solium metacestodes is related to down-regulation of osteopontin gene expression |
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