Biodegradable HA-PLA 3-D porous scaffolds: Effect of nano-sized filler content on scaffold properties
Scaffolds comprising poly(lactic acid) and nano-hydroxyapatite (HA) were prepared using the solvent-casting/salt-leaching technique. NaCl was used as the leaching agent. Nano-sized HA was synthesized by a hydrothermal method at 170 °C and autogenous pressure. High-resolution TEM imaging revealed tha...
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| Veröffentlicht in: | Acta biomaterialia 2005-11, Vol.1 (6), p.653-662 |
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| creator | Kothapalli, Chandrasekhar R. Shaw, Montgomery T. Wei, Mei |
| description | Scaffolds comprising poly(lactic acid) and nano-hydroxyapatite (HA) were prepared using the solvent-casting/salt-leaching technique. NaCl was used as the leaching agent. Nano-sized HA was synthesized by a hydrothermal method at 170
°C and autogenous pressure. High-resolution TEM imaging revealed that the HA particles were ellipsoidal-shaped with needle-like morphologies. The particles had an average size of approximately 25
nm in width and 150
nm in length with aspect ratios ranging from 6 to 8. As the HA content increased in the scaffold from 0 to 50
wt%, the compression modulus of the scaffolds increased from 4.72
±
1.2 to 9.87
±
1.8
MPa, while the yield strength from 0.29
±
0.03 to 0.44
±
0.01
MPa. Such polymeric scaffolds should be suitable materials for non-load sharing tissue-engineering applications. |
| doi_str_mv | 10.1016/j.actbio.2005.06.005 |
| format | Article |
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°C and autogenous pressure. High-resolution TEM imaging revealed that the HA particles were ellipsoidal-shaped with needle-like morphologies. The particles had an average size of approximately 25
nm in width and 150
nm in length with aspect ratios ranging from 6 to 8. As the HA content increased in the scaffold from 0 to 50
wt%, the compression modulus of the scaffolds increased from 4.72
±
1.2 to 9.87
±
1.8
MPa, while the yield strength from 0.29
±
0.03 to 0.44
±
0.01
MPa. Such polymeric scaffolds should be suitable materials for non-load sharing tissue-engineering applications.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2005.06.005</identifier><identifier>PMID: 16701846</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Absorbable Implants ; Absorption ; Biocompatible Materials - analysis ; Biocompatible Materials - chemistry ; Durapatite - analysis ; Durapatite - chemistry ; Hydroxyapatite ; Lactic Acid - analysis ; Lactic Acid - chemistry ; Materials Testing ; Mechanical strength ; Molecular Conformation ; Molecular Weight ; Nanostructures - analysis ; Nanostructures - chemistry ; Nanostructures - ultrastructure ; Particle Size ; Poly(lactic acid) ; Polyesters ; Polymers - analysis ; Polymers - chemistry ; Porosity ; Porous scaffolds ; Temperature ; Transition Temperature ; Water - chemistry</subject><ispartof>Acta biomaterialia, 2005-11, Vol.1 (6), p.653-662</ispartof><rights>2005 Actabio Materialia Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-3d8ac6f65c265926b188a742e1edab3a50e4b21a62ade98ae40e769c46f6a8763</citedby><cites>FETCH-LOGICAL-c422t-3d8ac6f65c265926b188a742e1edab3a50e4b21a62ade98ae40e769c46f6a8763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706105000978$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16701846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kothapalli, Chandrasekhar R.</creatorcontrib><creatorcontrib>Shaw, Montgomery T.</creatorcontrib><creatorcontrib>Wei, Mei</creatorcontrib><title>Biodegradable HA-PLA 3-D porous scaffolds: Effect of nano-sized filler content on scaffold properties</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>Scaffolds comprising poly(lactic acid) and nano-hydroxyapatite (HA) were prepared using the solvent-casting/salt-leaching technique. NaCl was used as the leaching agent. Nano-sized HA was synthesized by a hydrothermal method at 170
°C and autogenous pressure. High-resolution TEM imaging revealed that the HA particles were ellipsoidal-shaped with needle-like morphologies. The particles had an average size of approximately 25
nm in width and 150
nm in length with aspect ratios ranging from 6 to 8. As the HA content increased in the scaffold from 0 to 50
wt%, the compression modulus of the scaffolds increased from 4.72
±
1.2 to 9.87
±
1.8
MPa, while the yield strength from 0.29
±
0.03 to 0.44
±
0.01
MPa. Such polymeric scaffolds should be suitable materials for non-load sharing tissue-engineering applications.</description><subject>Absorbable Implants</subject><subject>Absorption</subject><subject>Biocompatible Materials - analysis</subject><subject>Biocompatible Materials - chemistry</subject><subject>Durapatite - analysis</subject><subject>Durapatite - chemistry</subject><subject>Hydroxyapatite</subject><subject>Lactic Acid - analysis</subject><subject>Lactic Acid - chemistry</subject><subject>Materials Testing</subject><subject>Mechanical strength</subject><subject>Molecular Conformation</subject><subject>Molecular Weight</subject><subject>Nanostructures - analysis</subject><subject>Nanostructures - chemistry</subject><subject>Nanostructures - ultrastructure</subject><subject>Particle Size</subject><subject>Poly(lactic acid)</subject><subject>Polyesters</subject><subject>Polymers - analysis</subject><subject>Polymers - chemistry</subject><subject>Porosity</subject><subject>Porous scaffolds</subject><subject>Temperature</subject><subject>Transition Temperature</subject><subject>Water - chemistry</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPxCAUhYnR-P4HxrBy1wq0BerCZNTxkUyiC10TChfDpFNG6JjorxczE93pghwSvnMfHIROKCkpofx8Xmozdj6UjJCmJLzMsoX2qRSyEA2X2_kualYIwukeOkhpTkglKZO7aI9yQais-T6CKx8svEZtddcDvp8UT7MJroobvAwxrBJORjsXepsu8NQ5MCMODg96CEXyn2Cx830PEZswjDDkx-HHgZcxLCGOHtIR2nG6T3C80UP0cjt9vr4vZo93D9eTWWFqxsaislIb7nhjGG9axjsqpc47AIU8XqUbAnXHqOZMW2ilhpqA4K2ps0dLwatDdLaum1u_rSCNauGTgb7XA-RlVN66kVUl_gVZW8t8mn9B2grGWUUyWK9BE0NKEZxaRr_Q8UNRor4DU3O1Dkx9B6YIV1my7XRTf9UtwP6aNgll4HINQP63dw9RJeNhMGB9zGkoG_zfHb4AspOoBw</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Kothapalli, Chandrasekhar R.</creator><creator>Shaw, Montgomery T.</creator><creator>Wei, Mei</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Biodegradable HA-PLA 3-D porous scaffolds: Effect of nano-sized filler content on scaffold properties</title><author>Kothapalli, Chandrasekhar R. ; Shaw, Montgomery T. ; Wei, Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-3d8ac6f65c265926b188a742e1edab3a50e4b21a62ade98ae40e769c46f6a8763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Absorbable Implants</topic><topic>Absorption</topic><topic>Biocompatible Materials - analysis</topic><topic>Biocompatible Materials - chemistry</topic><topic>Durapatite - analysis</topic><topic>Durapatite - chemistry</topic><topic>Hydroxyapatite</topic><topic>Lactic Acid - analysis</topic><topic>Lactic Acid - chemistry</topic><topic>Materials Testing</topic><topic>Mechanical strength</topic><topic>Molecular Conformation</topic><topic>Molecular Weight</topic><topic>Nanostructures - analysis</topic><topic>Nanostructures - chemistry</topic><topic>Nanostructures - ultrastructure</topic><topic>Particle Size</topic><topic>Poly(lactic acid)</topic><topic>Polyesters</topic><topic>Polymers - analysis</topic><topic>Polymers - chemistry</topic><topic>Porosity</topic><topic>Porous scaffolds</topic><topic>Temperature</topic><topic>Transition Temperature</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kothapalli, Chandrasekhar R.</creatorcontrib><creatorcontrib>Shaw, Montgomery T.</creatorcontrib><creatorcontrib>Wei, Mei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kothapalli, Chandrasekhar R.</au><au>Shaw, Montgomery T.</au><au>Wei, Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biodegradable HA-PLA 3-D porous scaffolds: Effect of nano-sized filler content on scaffold properties</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>1</volume><issue>6</issue><spage>653</spage><epage>662</epage><pages>653-662</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>Scaffolds comprising poly(lactic acid) and nano-hydroxyapatite (HA) were prepared using the solvent-casting/salt-leaching technique. NaCl was used as the leaching agent. Nano-sized HA was synthesized by a hydrothermal method at 170
°C and autogenous pressure. High-resolution TEM imaging revealed that the HA particles were ellipsoidal-shaped with needle-like morphologies. The particles had an average size of approximately 25
nm in width and 150
nm in length with aspect ratios ranging from 6 to 8. As the HA content increased in the scaffold from 0 to 50
wt%, the compression modulus of the scaffolds increased from 4.72
±
1.2 to 9.87
±
1.8
MPa, while the yield strength from 0.29
±
0.03 to 0.44
±
0.01
MPa. Such polymeric scaffolds should be suitable materials for non-load sharing tissue-engineering applications.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16701846</pmid><doi>10.1016/j.actbio.2005.06.005</doi><tpages>10</tpages></addata></record> |
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| ispartof | Acta biomaterialia, 2005-11, Vol.1 (6), p.653-662 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Absorbable Implants Absorption Biocompatible Materials - analysis Biocompatible Materials - chemistry Durapatite - analysis Durapatite - chemistry Hydroxyapatite Lactic Acid - analysis Lactic Acid - chemistry Materials Testing Mechanical strength Molecular Conformation Molecular Weight Nanostructures - analysis Nanostructures - chemistry Nanostructures - ultrastructure Particle Size Poly(lactic acid) Polyesters Polymers - analysis Polymers - chemistry Porosity Porous scaffolds Temperature Transition Temperature Water - chemistry |
| title | Biodegradable HA-PLA 3-D porous scaffolds: Effect of nano-sized filler content on scaffold properties |
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