Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication

Gene therapy has the potential to control human immunodeficiency virus (HIV) in patients who do not respond to traditional antiviral therapy. In this study, we tested foamy virus (FV) vectors expressing three anti-HIV transgenes, both individually and in a combination vector. The transgenes tested i...

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Veröffentlicht in:	Molecular therapy 2008-01, Vol.16 (1), p.46-51
Hauptverfasser:	Taylor, Jason A, Vojtech, Lucia, Bahner, Ingrid, Kohn, Donald B, Laer, Dorothee Von, Russell, David W, Richard, Robert E
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - chemical synthesis Cell Line Cells, Cultured Clinical trials Gene Expression Regulation, Viral Gene Products, rev - biosynthesis Gene Products, rev - genetics Gene therapy Gene Transfer Techniques Genetic Therapy Genetic Vectors - therapeutic use HIV HIV Envelope Protein gp41 - biosynthesis HIV Envelope Protein gp41 - genetics HIV Infections - genetics HIV Infections - prevention & control HIV Infections - virology HIV-1 - genetics Human immunodeficiency virus Humans Infections Kinases Peptides Plasmids RNA polymerase Spumavirus - genetics Stem cells Transgenes Vectors (Biology) Virus Replication - genetics
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