Relation of Apolipoprotein E Polymorphism to Markers of Early Atherosclerotic Changes in Young Adults: The Cardiovascular Risk in Young Finns Study
Background Carotid artery intima-media thickness (IMT), which is measured by ultrasound, is used in the assessment of early atherosclerotic changes, and has been associated with apolipoprotein E (APOE) polymorphism in many studies comprising elderly subjects. However, results are still inconclusive...
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| Veröffentlicht in: | Circulation Journal 2008, Vol.72(1), pp.29-34 |
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| creator | Grönroos, Paula Raitakari, Olli T. Kähönen, Mika Hutri-Kähönen, Nina Juonala, Markus Marniemi, Jukka Viikari, Jorma Lehtimäki, Terho |
| description | Background Carotid artery intima-media thickness (IMT), which is measured by ultrasound, is used in the assessment of early atherosclerotic changes, and has been associated with apolipoprotein E (APOE) polymorphism in many studies comprising elderly subjects. However, results are still inconclusive and data relating to young adults are missing. Whether common APOE polymorphism is related to carotid IMT was studied in a population of young adults. Also brachial flow-mediated dilatation (FMD) and carotid artery compliance (CAC) were determined to clarify their relation to this genetic factor. Methods and Results A total of 1,188 young adults (aged 24-39 years) participating in the Cardiovascular Risk in Young Finns Study with complete data of common APOE polymorphism underwent a carotid and brachial ultrasound. Patients' lipid levels and blood pressure were also examined. There was no significant association between the APOE phenotypes and carotid IMT, brachial FMD or CAC either in young men or in young women. The results were similar for systolic and diastolic blood pressure. In the same population, the well-known association between APOE phenotypes and lipids was seen. Conclusions Common APOE polymorphism does not seem to be an independent genetic determinant of carotid IMT, brachial FMD or CAC. (Circ J 2008; 72: 29 - 34) |
| doi_str_mv | 10.1253/circj.72.29 |
| format | Article |
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However, results are still inconclusive and data relating to young adults are missing. Whether common APOE polymorphism is related to carotid IMT was studied in a population of young adults. Also brachial flow-mediated dilatation (FMD) and carotid artery compliance (CAC) were determined to clarify their relation to this genetic factor. Methods and Results A total of 1,188 young adults (aged 24-39 years) participating in the Cardiovascular Risk in Young Finns Study with complete data of common APOE polymorphism underwent a carotid and brachial ultrasound. Patients' lipid levels and blood pressure were also examined. There was no significant association between the APOE phenotypes and carotid IMT, brachial FMD or CAC either in young men or in young women. The results were similar for systolic and diastolic blood pressure. In the same population, the well-known association between APOE phenotypes and lipids was seen. Conclusions Common APOE polymorphism does not seem to be an independent genetic determinant of carotid IMT, brachial FMD or CAC. (Circ J 2008; 72: 29 - 34)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.72.29</identifier><identifier>PMID: 18159095</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Adult ; Apolipoproteins E ; Apolipoproteins E - genetics ; Atherosclerosis ; Atherosclerosis - blood ; Atherosclerosis - pathology ; Atherosclerosis - physiopathology ; Biomarkers - analysis ; Blood Pressure ; Brachial Artery - diagnostic imaging ; Brachial Artery - physiopathology ; Carotid arteries ; Carotid Arteries - diagnostic imaging ; Cholesterol ; Female ; Genetic polymorphism ; Humans ; Lipids - blood ; Male ; Polymorphism, Genetic ; Tunica Intima - diagnostic imaging ; Tunica Media - diagnostic imaging ; Ultrasonography ; Vasodilation</subject><ispartof>Circulation Journal, 2008, Vol.72(1), pp.29-34</ispartof><rights>2008 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-c3d1eaf4ac0d4f15106a820f52f3cd4c72a9a87a0695efd8d19c6b6f5edd54ee3</citedby><cites>FETCH-LOGICAL-c447t-c3d1eaf4ac0d4f15106a820f52f3cd4c72a9a87a0695efd8d19c6b6f5edd54ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18159095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grönroos, Paula</creatorcontrib><creatorcontrib>Raitakari, Olli T.</creatorcontrib><creatorcontrib>Kähönen, Mika</creatorcontrib><creatorcontrib>Hutri-Kähönen, Nina</creatorcontrib><creatorcontrib>Juonala, Markus</creatorcontrib><creatorcontrib>Marniemi, Jukka</creatorcontrib><creatorcontrib>Viikari, Jorma</creatorcontrib><creatorcontrib>Lehtimäki, Terho</creatorcontrib><title>Relation of Apolipoprotein E Polymorphism to Markers of Early Atherosclerotic Changes in Young Adults: The Cardiovascular Risk in Young Finns Study</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background Carotid artery intima-media thickness (IMT), which is measured by ultrasound, is used in the assessment of early atherosclerotic changes, and has been associated with apolipoprotein E (APOE) polymorphism in many studies comprising elderly subjects. However, results are still inconclusive and data relating to young adults are missing. Whether common APOE polymorphism is related to carotid IMT was studied in a population of young adults. Also brachial flow-mediated dilatation (FMD) and carotid artery compliance (CAC) were determined to clarify their relation to this genetic factor. Methods and Results A total of 1,188 young adults (aged 24-39 years) participating in the Cardiovascular Risk in Young Finns Study with complete data of common APOE polymorphism underwent a carotid and brachial ultrasound. Patients' lipid levels and blood pressure were also examined. There was no significant association between the APOE phenotypes and carotid IMT, brachial FMD or CAC either in young men or in young women. The results were similar for systolic and diastolic blood pressure. In the same population, the well-known association between APOE phenotypes and lipids was seen. Conclusions Common APOE polymorphism does not seem to be an independent genetic determinant of carotid IMT, brachial FMD or CAC. (Circ J 2008; 72: 29 - 34)</description><subject>Adult</subject><subject>Apolipoproteins E</subject><subject>Apolipoproteins E - genetics</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - pathology</subject><subject>Atherosclerosis - physiopathology</subject><subject>Biomarkers - analysis</subject><subject>Blood Pressure</subject><subject>Brachial Artery - diagnostic imaging</subject><subject>Brachial Artery - physiopathology</subject><subject>Carotid arteries</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Cholesterol</subject><subject>Female</subject><subject>Genetic polymorphism</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Polymorphism, Genetic</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Tunica Media - diagnostic imaging</subject><subject>Ultrasonography</subject><subject>Vasodilation</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFvEzEQha0KREvLqffKJy5og-21d9c3oihQpCIQKgdOlmuPk02968X2HvLvcZqoucyMNN88zXsI3VKyoEzUn00fzW7RsgWTF-iK1ryteMfIm5e5qWTH60v0PqUdIUwSId-hS9pRIYkUVwh-g9e5DyMODi-n4PspTDFk6Ee8xr-C3w8hTts-DTgH_EPHZ4jpwK519Hu8zFuIIRlfau4NXm31uIGEy_XfMI8bvLSzz-kGvXXaJ_hw6tfoz9f14-q-evj57ftq-VAZzttcmdpS0I5rQyx3VFDS6OLECeZqY7lpmZa6azVppABnO0ulaZ4aJ8BawQHqa_TxqFss_JshZTX0yYD3eoQwJ9USKlrGRQE_HUFTvk8RnJpiP-i4V5SoQ6rqJVXVMsVkoe9OsvPTAPbMnmIswJcjsEtZb-AV0LGE4uEsRo-FyfNqq6OCsf4PtT6NVQ</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Grönroos, Paula</creator><creator>Raitakari, Olli T.</creator><creator>Kähönen, Mika</creator><creator>Hutri-Kähönen, Nina</creator><creator>Juonala, Markus</creator><creator>Marniemi, Jukka</creator><creator>Viikari, Jorma</creator><creator>Lehtimäki, Terho</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Relation of Apolipoprotein E Polymorphism to Markers of Early Atherosclerotic Changes in Young Adults</title><author>Grönroos, Paula ; Raitakari, Olli T. ; Kähönen, Mika ; Hutri-Kähönen, Nina ; Juonala, Markus ; Marniemi, Jukka ; Viikari, Jorma ; Lehtimäki, Terho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-c3d1eaf4ac0d4f15106a820f52f3cd4c72a9a87a0695efd8d19c6b6f5edd54ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Apolipoproteins E</topic><topic>Apolipoproteins E - genetics</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - pathology</topic><topic>Atherosclerosis - physiopathology</topic><topic>Biomarkers - analysis</topic><topic>Blood Pressure</topic><topic>Brachial Artery - diagnostic imaging</topic><topic>Brachial Artery - physiopathology</topic><topic>Carotid arteries</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Cholesterol</topic><topic>Female</topic><topic>Genetic polymorphism</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Polymorphism, Genetic</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Tunica Media - diagnostic imaging</topic><topic>Ultrasonography</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grönroos, Paula</creatorcontrib><creatorcontrib>Raitakari, Olli T.</creatorcontrib><creatorcontrib>Kähönen, Mika</creatorcontrib><creatorcontrib>Hutri-Kähönen, Nina</creatorcontrib><creatorcontrib>Juonala, Markus</creatorcontrib><creatorcontrib>Marniemi, Jukka</creatorcontrib><creatorcontrib>Viikari, Jorma</creatorcontrib><creatorcontrib>Lehtimäki, Terho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grönroos, Paula</au><au>Raitakari, Olli T.</au><au>Kähönen, Mika</au><au>Hutri-Kähönen, Nina</au><au>Juonala, Markus</au><au>Marniemi, Jukka</au><au>Viikari, Jorma</au><au>Lehtimäki, Terho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of Apolipoprotein E Polymorphism to Markers of Early Atherosclerotic Changes in Young Adults: The Cardiovascular Risk in Young Finns Study</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2008</date><risdate>2008</risdate><volume>72</volume><issue>1</issue><spage>29</spage><epage>34</epage><pages>29-34</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background Carotid artery intima-media thickness (IMT), which is measured by ultrasound, is used in the assessment of early atherosclerotic changes, and has been associated with apolipoprotein E (APOE) polymorphism in many studies comprising elderly subjects. However, results are still inconclusive and data relating to young adults are missing. Whether common APOE polymorphism is related to carotid IMT was studied in a population of young adults. Also brachial flow-mediated dilatation (FMD) and carotid artery compliance (CAC) were determined to clarify their relation to this genetic factor. Methods and Results A total of 1,188 young adults (aged 24-39 years) participating in the Cardiovascular Risk in Young Finns Study with complete data of common APOE polymorphism underwent a carotid and brachial ultrasound. Patients' lipid levels and blood pressure were also examined. There was no significant association between the APOE phenotypes and carotid IMT, brachial FMD or CAC either in young men or in young women. The results were similar for systolic and diastolic blood pressure. In the same population, the well-known association between APOE phenotypes and lipids was seen. Conclusions Common APOE polymorphism does not seem to be an independent genetic determinant of carotid IMT, brachial FMD or CAC. (Circ J 2008; 72: 29 - 34)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>18159095</pmid><doi>10.1253/circj.72.29</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation Journal, 2008, Vol.72(1), pp.29-34 |
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| subjects | Adult Apolipoproteins E Apolipoproteins E - genetics Atherosclerosis Atherosclerosis - blood Atherosclerosis - pathology Atherosclerosis - physiopathology Biomarkers - analysis Blood Pressure Brachial Artery - diagnostic imaging Brachial Artery - physiopathology Carotid arteries Carotid Arteries - diagnostic imaging Cholesterol Female Genetic polymorphism Humans Lipids - blood Male Polymorphism, Genetic Tunica Intima - diagnostic imaging Tunica Media - diagnostic imaging Ultrasonography Vasodilation |
| title | Relation of Apolipoprotein E Polymorphism to Markers of Early Atherosclerotic Changes in Young Adults: The Cardiovascular Risk in Young Finns Study |
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