Live cell vaccines expressing B7.1, monocyte chemoattractant protein 1 and granulocyte-macrophage colony stimulation factor derived from mouse HPV16-transformed cells

One of the gene therapy strategies in oncology is immunization with cancer cells that express various cytokines. We used a thymidine-kinase deficient (cTK-) cell line designated 123IA, which had been derived from HPV16-transformed mouse (C57BL/6) cells MK16/I/III/ABC (MK16). To obtain genetically mo...

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Veröffentlicht in:	International journal of oncology 2008, Vol.32 (1), p.265-271
Hauptverfasser:	LAKATOSOVA-ANDELOVA, Monika, JINOCH, Pavel, DUSKOVA, Martina, MARINOV, Iuri, VONKA, Vladimir
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Animals B7-1 Antigen - genetics Biological and medical sciences Cancer Vaccines - immunology Cell Line Cell Line, Transformed Chemokine CCL2 - genetics Female Ganciclovir - pharmacology Genes, MHC Class I Granulocyte-Macrophage Colony-Stimulating Factor - genetics Human papillomavirus 16 - genetics Human viral diseases Immunization Infectious diseases Medical sciences Mice Mice, Inbred C57BL Oncogene Proteins, Viral - genetics Papillomavirus E7 Proteins Repressor Proteins - genetics Transfection Tumors Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
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