Activity of nitric oxide synthase and concentration of nitric oxide end metabolites in the gingiva under experimental pathological conditions

Parameters of NO metabolism in the gingiva were studied during experimental periodontitis accompanied by alloxan diabetes and exogenous hypercholesterolemia. We measured activities of inducible and constitutive NO synthase and concentrations of stable NO end metabolites in rat gingival tissue (total...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-10, Vol.140 (4), p.391-393
Hauptverfasser:	Popkov, V L, Fil'chukova, I A, Lapina, N V, Galenko-Yaroshevskii, V P, Dukhanin, A S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Gingiva - metabolism Gingiva - pathology Male Nitric Oxide - metabolism Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - antagonists & inhibitors Nitric Oxide Synthase Type III - metabolism Oxidative Stress Periodontitis - enzymology Periodontitis - metabolism Picolines - pharmacology Rats
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Zusammenfassung:	Parameters of NO metabolism in the gingiva were studied during experimental periodontitis accompanied by alloxan diabetes and exogenous hypercholesterolemia. We measured activities of inducible and constitutive NO synthase and concentrations of stable NO end metabolites in rat gingival tissue (total contents of nitrite and nitrate). Under pathological conditions NO-metabolism significantly differed from the control. Treatment with mexidol for 14 days significantly decreased activity of inducible NO synthase in the gingiva of experimental animals.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0499-4