Thymidylate synthase polymorphisms and mRNA expression are independent chemotherapy predictive markers in esophageal adenocarcinoma patients

Thymidylate synthase (TS) is known to have polymorphisms in the 5' and 3' untranslated region (UTR). These polymorphisms have been reported to be associated with high TS expression and chemoresistance to 5-FU. The aim of this study was to examine the prognostic roles of the 5'-UTR and...

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Veröffentlicht in:	International journal of oncology 2008, Vol.32 (1), p.201-208
Hauptverfasser:	KURAMOCHI, Hidekazu, TANAKA, Koji, DANENBERG, Peter V, OH, Daniel, LEHMAN, Bethany J, DUNST, Christy M, DONG YUN YANG, DE MEESTER, Steven R, HAGEN, Jeffery A, DANENBERG, Kathleen D, DE MEESTER, Tom R
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics 5' Untranslated Regions - genetics Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adult Aged Biological and medical sciences Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Genotype Humans Loss of Heterozygosity Male Medical sciences Middle Aged Polymorphism, Genetic Prognosis RNA, Messenger - analysis Thymidylate Synthase - genetics Tumors
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