Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis
The immunopathological evaluation of the hepatic compartment associated with parasitism and biochemical findings are essential for understanding the genesis of hepatomegaly in canine visceral leishmaniasis (CVL). Three clinical groups of dogs naturally infected with Leishmania chagasi [i.e., asympto...
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| Veröffentlicht in: | Research in veterinary science 2008-04, Vol.84 (2), p.269-277 |
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| creator | Giunchetti, Rodolfo Cordeiro Mayrink, Wilson Carneiro, Cláudia Martins Corrêa-Oliveira, Rodrigo Martins-Filho, Olindo Assis Marques, Marcos José Tafuri, Washington Luiz Reis, Alexandre Barbosa |
| description | The immunopathological evaluation of the hepatic compartment associated with parasitism and biochemical findings are essential for understanding the genesis of hepatomegaly in canine visceral leishmaniasis (CVL). Three clinical groups of dogs naturally infected with
Leishmania chagasi [i.e., asymptomatic (AD,
n
=
12), oligosymptomatic (OD,
n
=
12) and symptomatic (SD,
n
=
17)] were assessed and compared with a group of non-infected dogs (NID,
n
=
11). Intense reaction of the Kupffer cells, capsule and portal inflammation, and the presence of intralobular granulomas, were observed in the different clinical groups. Dogs in the SD group presented a higher frequency of parasitism compared with the AD group. Inflammatory alterations were more intense in the SD group and were associated with parasitism. Our results indicated an association between histological liver changes and the progression of biochemical alterations according to progression of clinical forms of CVL, and the direct relationship between clinical symptoms and frequency of hepatic parasitism. |
| doi_str_mv | 10.1016/j.rvsc.2007.04.020 |
| format | Article |
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Leishmania chagasi [i.e., asymptomatic (AD,
n
=
12), oligosymptomatic (OD,
n
=
12) and symptomatic (SD,
n
=
17)] were assessed and compared with a group of non-infected dogs (NID,
n
=
11). Intense reaction of the Kupffer cells, capsule and portal inflammation, and the presence of intralobular granulomas, were observed in the different clinical groups. Dogs in the SD group presented a higher frequency of parasitism compared with the AD group. Inflammatory alterations were more intense in the SD group and were associated with parasitism. Our results indicated an association between histological liver changes and the progression of biochemical alterations according to progression of clinical forms of CVL, and the direct relationship between clinical symptoms and frequency of hepatic parasitism.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2007.04.020</identifier><identifier>PMID: 17604064</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>Animals ; blood chemistry ; blood serum ; Bone marrow ; disease course ; disease severity ; Dog ; dog diseases ; Dog Diseases - blood ; Dog Diseases - immunology ; Dog Diseases - pathology ; Dogs ; Female ; granuloma ; Histopathology ; Immunohistochemistry ; Immunohistochemistry - veterinary ; inflammation ; Kupffer cells ; LDU index ; Leishmania chagasi ; Leishmania donovani ; Leishmaniasis, Visceral - blood ; Leishmaniasis, Visceral - immunology ; Leishmaniasis, Visceral - pathology ; Leishmaniasis, Visceral - veterinary ; Liver ; Liver - immunology ; Liver - pathology ; Male ; Parasites ; Parasitic diseases ; Parasitism ; pathogenesis ; Veterinary medicine ; Visceral leishmaniasis</subject><ispartof>Research in veterinary science, 2008-04, Vol.84 (2), p.269-277</ispartof><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-716e6ad4cfde2dce14e556194fcfe4897ff4746ff54fc6254f759e311e6e3593</citedby><cites>FETCH-LOGICAL-c406t-716e6ad4cfde2dce14e556194fcfe4897ff4746ff54fc6254f759e311e6e3593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0034528807001245$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17604064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giunchetti, Rodolfo Cordeiro</creatorcontrib><creatorcontrib>Mayrink, Wilson</creatorcontrib><creatorcontrib>Carneiro, Cláudia Martins</creatorcontrib><creatorcontrib>Corrêa-Oliveira, Rodrigo</creatorcontrib><creatorcontrib>Martins-Filho, Olindo Assis</creatorcontrib><creatorcontrib>Marques, Marcos José</creatorcontrib><creatorcontrib>Tafuri, Washington Luiz</creatorcontrib><creatorcontrib>Reis, Alexandre Barbosa</creatorcontrib><title>Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>The immunopathological evaluation of the hepatic compartment associated with parasitism and biochemical findings are essential for understanding the genesis of hepatomegaly in canine visceral leishmaniasis (CVL). Three clinical groups of dogs naturally infected with
Leishmania chagasi [i.e., asymptomatic (AD,
n
=
12), oligosymptomatic (OD,
n
=
12) and symptomatic (SD,
n
=
17)] were assessed and compared with a group of non-infected dogs (NID,
n
=
11). Intense reaction of the Kupffer cells, capsule and portal inflammation, and the presence of intralobular granulomas, were observed in the different clinical groups. Dogs in the SD group presented a higher frequency of parasitism compared with the AD group. Inflammatory alterations were more intense in the SD group and were associated with parasitism. Our results indicated an association between histological liver changes and the progression of biochemical alterations according to progression of clinical forms of CVL, and the direct relationship between clinical symptoms and frequency of hepatic parasitism.</description><subject>Animals</subject><subject>blood chemistry</subject><subject>blood serum</subject><subject>Bone marrow</subject><subject>disease course</subject><subject>disease severity</subject><subject>Dog</subject><subject>dog diseases</subject><subject>Dog Diseases - blood</subject><subject>Dog Diseases - immunology</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Female</subject><subject>granuloma</subject><subject>Histopathology</subject><subject>Immunohistochemistry</subject><subject>Immunohistochemistry - veterinary</subject><subject>inflammation</subject><subject>Kupffer cells</subject><subject>LDU index</subject><subject>Leishmania chagasi</subject><subject>Leishmania donovani</subject><subject>Leishmaniasis, Visceral - blood</subject><subject>Leishmaniasis, Visceral - immunology</subject><subject>Leishmaniasis, Visceral - pathology</subject><subject>Leishmaniasis, Visceral - veterinary</subject><subject>Liver</subject><subject>Liver - immunology</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Parasitism</subject><subject>pathogenesis</subject><subject>Veterinary medicine</subject><subject>Visceral leishmaniasis</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGKFDEQhhtR3HH1BTxoQPA2Y6U7Sc-Al2VRV1jw4HoO2XRlOkMnGZP0iA_lO1qzM7DgQQgJVH31p6r-pnnNYcWBqw-7VT4Uu2oB-hWIFbTwpFlw2bXLVin-tFkAdGIp2_X6onlRyg4ABOf98-aC9woEKLFo_tz4UtPe1DFNaeutmZiJA_MhzDGNx5wdMTzEfTxgqX5rqk-xsORYHZGNSMXeMpvC3uQaMFZmSknWm4oD--XryChhiq--hAfxgnkO7N4_StvRxC0W-oJZE31EdvDFYqbUhL6MgYKkUF42z5yZCr46v5fN3edPd9c3y9tvX75eX90uLU1Vlz1XqMwgrBuwHSxygVIqvhHOOhTrTe-c6IVyTlJEtXT3coMd56iwk5vusnl_kt3n9HOmoXU4tjNNJmKai-6BtryWgsB3_4C7NOdIrWkOnaQjOSeqPVE2p1IyOr3PPpj8myB9dFLv9NFJfXRSg9DkJBW9OUvP9wGHx5KzdQS8PQHOJG222Rf943sLvANYiw0oScTHE4G0qoPHrIv1GC0OPqOtekj-fx38BfDrvk8</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Giunchetti, Rodolfo Cordeiro</creator><creator>Mayrink, Wilson</creator><creator>Carneiro, Cláudia Martins</creator><creator>Corrêa-Oliveira, Rodrigo</creator><creator>Martins-Filho, Olindo Assis</creator><creator>Marques, Marcos José</creator><creator>Tafuri, Washington Luiz</creator><creator>Reis, Alexandre Barbosa</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis</title><author>Giunchetti, Rodolfo Cordeiro ; Mayrink, Wilson ; Carneiro, Cláudia Martins ; Corrêa-Oliveira, Rodrigo ; Martins-Filho, Olindo Assis ; Marques, Marcos José ; Tafuri, Washington Luiz ; Reis, Alexandre Barbosa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-716e6ad4cfde2dce14e556194fcfe4897ff4746ff54fc6254f759e311e6e3593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>blood chemistry</topic><topic>blood serum</topic><topic>Bone marrow</topic><topic>disease course</topic><topic>disease severity</topic><topic>Dog</topic><topic>dog diseases</topic><topic>Dog Diseases - blood</topic><topic>Dog Diseases - immunology</topic><topic>Dog Diseases - pathology</topic><topic>Dogs</topic><topic>Female</topic><topic>granuloma</topic><topic>Histopathology</topic><topic>Immunohistochemistry</topic><topic>Immunohistochemistry - veterinary</topic><topic>inflammation</topic><topic>Kupffer cells</topic><topic>LDU index</topic><topic>Leishmania chagasi</topic><topic>Leishmania donovani</topic><topic>Leishmaniasis, Visceral - blood</topic><topic>Leishmaniasis, Visceral - immunology</topic><topic>Leishmaniasis, Visceral - pathology</topic><topic>Leishmaniasis, Visceral - veterinary</topic><topic>Liver</topic><topic>Liver - immunology</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Parasitism</topic><topic>pathogenesis</topic><topic>Veterinary medicine</topic><topic>Visceral leishmaniasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giunchetti, Rodolfo Cordeiro</creatorcontrib><creatorcontrib>Mayrink, Wilson</creatorcontrib><creatorcontrib>Carneiro, Cláudia Martins</creatorcontrib><creatorcontrib>Corrêa-Oliveira, Rodrigo</creatorcontrib><creatorcontrib>Martins-Filho, Olindo Assis</creatorcontrib><creatorcontrib>Marques, Marcos José</creatorcontrib><creatorcontrib>Tafuri, Washington Luiz</creatorcontrib><creatorcontrib>Reis, Alexandre Barbosa</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giunchetti, Rodolfo Cordeiro</au><au>Mayrink, Wilson</au><au>Carneiro, Cláudia Martins</au><au>Corrêa-Oliveira, Rodrigo</au><au>Martins-Filho, Olindo Assis</au><au>Marques, Marcos José</au><au>Tafuri, Washington Luiz</au><au>Reis, Alexandre Barbosa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>84</volume><issue>2</issue><spage>269</spage><epage>277</epage><pages>269-277</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>The immunopathological evaluation of the hepatic compartment associated with parasitism and biochemical findings are essential for understanding the genesis of hepatomegaly in canine visceral leishmaniasis (CVL). Three clinical groups of dogs naturally infected with
Leishmania chagasi [i.e., asymptomatic (AD,
n
=
12), oligosymptomatic (OD,
n
=
12) and symptomatic (SD,
n
=
17)] were assessed and compared with a group of non-infected dogs (NID,
n
=
11). Intense reaction of the Kupffer cells, capsule and portal inflammation, and the presence of intralobular granulomas, were observed in the different clinical groups. Dogs in the SD group presented a higher frequency of parasitism compared with the AD group. Inflammatory alterations were more intense in the SD group and were associated with parasitism. Our results indicated an association between histological liver changes and the progression of biochemical alterations according to progression of clinical forms of CVL, and the direct relationship between clinical symptoms and frequency of hepatic parasitism.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>17604064</pmid><doi>10.1016/j.rvsc.2007.04.020</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals blood chemistry blood serum Bone marrow disease course disease severity Dog dog diseases Dog Diseases - blood Dog Diseases - immunology Dog Diseases - pathology Dogs Female granuloma Histopathology Immunohistochemistry Immunohistochemistry - veterinary inflammation Kupffer cells LDU index Leishmania chagasi Leishmania donovani Leishmaniasis, Visceral - blood Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - pathology Leishmaniasis, Visceral - veterinary Liver Liver - immunology Liver - pathology Male Parasites Parasitic diseases Parasitism pathogenesis Veterinary medicine Visceral leishmaniasis |
| title | Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis |
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