DNA strand-scission by phloroglucinols and lignans from heartwood of Garcinia subelliptica Merr. and Justicia plants

Phloroglucinols, garcinielliptones HA ( 1), HB ( 2), HC ( 3), HD ( 4) and HE ( 5), isolated from the heartwood of Garcinia subelliptica, were identified by extensive analysis of spectroscopic data. In the presence of Cu(II), compound 3 and lignans, isolated from Justicia plants, 8, 10 and 11 caused...

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Veröffentlicht in:	Phytochemistry (Oxford) 2008, Vol.69 (1), p.225-233
Hauptverfasser:	Lu, Yi-Huang, Wei, Bai-Luh, Ko, Horng-Huey, Lin, Chun-Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthaceae Acanthaceae - chemistry Biological and medical sciences Chemical constitution chemical structure Clusiaceae Copper - chemistry DNA Cleavage - drug effects DNA damage DNA Damage - drug effects DNA strand-scission activity DNA, Circular - drug effects DNA, Circular - metabolism DNA, Superhelical - drug effects DNA, Superhelical - metabolism Electrophoresis, Agar Gel Fundamental and applied biological sciences. Psychology Garcinia - chemistry Garcinia subelliptica garcinielliptone Guttiferae Heartwood Justicia Justicia ciliata Justicia procumbens Lignan lignans Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Magnetic Resonance Spectroscopy Metabolism Metabolism. Physicochemical requirements Phenanthrolines - pharmacology phenols Phloroglucinol Phloroglucinol - chemistry Phloroglucinol - isolation & purification Phloroglucinol - pharmacology phloroglucinols Plant physiology and development Reactive Oxygen Species - metabolism spectral analysis Spectrophotometry, Infrared stereochemistry Wood - chemistry
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