Localization of S100A8 and S100A9 expressing neutrophils to spinal cord during peripheral tissue inflammation

Investigation of hyperalgesia at the spinal transcriptome level indicated that carrageenan-induced inflammation of rat hind paws leads to a rapid but sustained increase in S100A8 and S100A9 expression, two genes implicated in the pathology of numerous inflammatory diseases including rheumatoid arthr...

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Veröffentlicht in:	Pain (Amsterdam) 2008, Vol.134 (1), p.216-231
Hauptverfasser:	Mitchell, Kendall, Yang, Hsiu-Ying T., Tessier, Philippe A., Muhly, W. Taylor, Swaim, William D., Szalayova, Ildiko, Keller, Jason M., Mezey, Eva, Iadarola, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood-Brain Barrier - physiology Blood–brain barrier Calgranulin A - biosynthesis Calgranulin A - genetics Calgranulin A - metabolism Calgranulin B - biosynthesis Calgranulin B - genetics Calgranulin B - metabolism Cell Communication - genetics Cell Communication - physiology Dimerization Edema - genetics Edema - metabolism Edema - pathology Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - secretion Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Hindlimb - metabolism Hindlimb - pathology Inflammation Inflammation Mediators - metabolism Inflammation Mediators - physiology Innate immune system Male Medical sciences Nervous system (semeiology, syndromes) Nervous system as a whole Neuroimmunology Neurology Neutrophils Neutrophils - metabolism Neutrophils - pathology Neutrophils - secretion Nociception Rats Rats, Sprague-Dawley Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - chemistry Spinal Cord - metabolism Spinal Cord - pathology Vertebrates: nervous system and sense organs
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