Diagnostic Transcranial Ultrasound Perfusion-Imaging at 2.5 MHz Does Not Affect the Blood-Brain Barrier
Abstract The purpose was to assess whether standard ultrasound (US) perfusion-imaging by means of contrast-enhanced transcranial color-coded sonography (TCCS) affects the blood-brain barrier (BBB) in patients with small-vessel disease (SVD). One week after a screening MRI to exclude a preexisting BB...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2008-01, Vol.34 (1), p.147-150 |
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| creator | Jungehulsing, Gerhard J Brunecker, Peter Nolte, Christian H Fiebach, Jochen B Kunze, Claudia Doepp, Florian Villringer, Arno Schreiber, Stephan J |
| description | Abstract The purpose was to assess whether standard ultrasound (US) perfusion-imaging by means of contrast-enhanced transcranial color-coded sonography (TCCS) affects the blood-brain barrier (BBB) in patients with small-vessel disease (SVD). One week after a screening MRI to exclude a preexisting BBB disruption, unilateral TCCS phase inversion harmonic imaging (PIHI) was performed in an axial diencephalic plane after intravenous bolus application of 2.5 mL SonoVue (IGEA, Bracco, Italy). Magnetic resonance imaging (MRI) was performed immediately after US. In five patients, PIHI was performed applying a mean mechanical index (MI) of 0.7 ± 0.1 for a time period of 2.5 min. MRI was started 12 ± 2 min after US contrast injection. Comparisons of initial and post-US MRI by four blinded readers did not show any signs of BBB disruption. It is concluded that standard contrast-enhanced US perfusion imaging in patients with SVD did not lead to MRI-detectable BBB changes. This gives further evidence for safety of diagnostic US. Future investigations with larger sample sizes and higher-field MRI might give further insights into potential bioeffects of diagnostic, as well as therapeutic, contrast-enhanced transcranial US. (E-mail: jan.jungehuelsing@charite.de ) |
| doi_str_mv | 10.1016/j.ultrasmedbio.2007.07.006 |
| format | Article |
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One week after a screening MRI to exclude a preexisting BBB disruption, unilateral TCCS phase inversion harmonic imaging (PIHI) was performed in an axial diencephalic plane after intravenous bolus application of 2.5 mL SonoVue (IGEA, Bracco, Italy). Magnetic resonance imaging (MRI) was performed immediately after US. In five patients, PIHI was performed applying a mean mechanical index (MI) of 0.7 ± 0.1 for a time period of 2.5 min. MRI was started 12 ± 2 min after US contrast injection. Comparisons of initial and post-US MRI by four blinded readers did not show any signs of BBB disruption. It is concluded that standard contrast-enhanced US perfusion imaging in patients with SVD did not lead to MRI-detectable BBB changes. This gives further evidence for safety of diagnostic US. Future investigations with larger sample sizes and higher-field MRI might give further insights into potential bioeffects of diagnostic, as well as therapeutic, contrast-enhanced transcranial US. 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One week after a screening MRI to exclude a preexisting BBB disruption, unilateral TCCS phase inversion harmonic imaging (PIHI) was performed in an axial diencephalic plane after intravenous bolus application of 2.5 mL SonoVue (IGEA, Bracco, Italy). Magnetic resonance imaging (MRI) was performed immediately after US. In five patients, PIHI was performed applying a mean mechanical index (MI) of 0.7 ± 0.1 for a time period of 2.5 min. MRI was started 12 ± 2 min after US contrast injection. Comparisons of initial and post-US MRI by four blinded readers did not show any signs of BBB disruption. It is concluded that standard contrast-enhanced US perfusion imaging in patients with SVD did not lead to MRI-detectable BBB changes. This gives further evidence for safety of diagnostic US. Future investigations with larger sample sizes and higher-field MRI might give further insights into potential bioeffects of diagnostic, as well as therapeutic, contrast-enhanced transcranial US. (E-mail: jan.jungehuelsing@charite.de )</description><subject>Adult</subject><subject>Aged</subject><subject>Bioeffects</subject><subject>Blood-Brain Barrier</subject><subject>Cerebral Infarction - diagnostic imaging</subject><subject>Cerebral Infarction - physiopathology</subject><subject>Contrast Media</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Middle Aged</subject><subject>Phase inversion harmonic imaging</subject><subject>Phospholipids</subject><subject>Radiology</subject><subject>Sulfur Hexafluoride</subject><subject>Thalamus - blood supply</subject><subject>Time Factors</subject><subject>Transcranial color-coded sonography</subject><subject>Ultrasonography, Doppler, Color - adverse effects</subject><subject>Ultrasonography, Doppler, Color - methods</subject><subject>Ultrasonography, Doppler, Transcranial - adverse effects</subject><subject>Ultrasonography, Doppler, Transcranial - methods</subject><subject>Ultrasound</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQQC0EokvhLyCLA7eEsRPbCQekbhdopfIh0UrcLMeZLF6ydrETpPLrcborgTghjezDvJnRvCHkBYOSAZOvduU8TtGkPfadCyUHUOUSIB-QFWtUW_CWfX1IVlABK4Tk7Ql5ktIOMigr9ZicMNWIum3Yimw3zmx9SJOz9Doan2x-nBnpzf2IMPuefsY4zMkFX1zuzdb5LTUT5aWgHy5-0U3ARD-GiZ4NA9qJTt-QrscQ-mIdjfN0bWJ0GJ-SR4MZEz47_qfk5t3b6_OL4urT-8vzs6vC1lU1FXUvueGSDdXQWGybWiEYUKJGwxmy-2zN2SA61gklG4N9L1nbNcJaAFZXp-Tloe9tDD9mTJPeu2RxHI3HMCetMtQ2QmTw9QG0MaQUcdC30e1NvNMM9KJZ7_TfmvWiWS8BMhc_P06Zu5z-U3r0moHNAcC868-8v07WobfYu5gt6T64_5vz5p82dnTeWTN-xztMuzBHn21qphPXoL8sB1_uDQqgytaq37pGqhQ</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Jungehulsing, Gerhard J</creator><creator>Brunecker, Peter</creator><creator>Nolte, Christian H</creator><creator>Fiebach, Jochen B</creator><creator>Kunze, Claudia</creator><creator>Doepp, Florian</creator><creator>Villringer, Arno</creator><creator>Schreiber, Stephan J</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Diagnostic Transcranial Ultrasound Perfusion-Imaging at 2.5 MHz Does Not Affect the Blood-Brain Barrier</title><author>Jungehulsing, Gerhard J ; 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| subjects | Adult Aged Bioeffects Blood-Brain Barrier Cerebral Infarction - diagnostic imaging Cerebral Infarction - physiopathology Contrast Media Humans Magnetic Resonance Imaging Middle Aged Phase inversion harmonic imaging Phospholipids Radiology Sulfur Hexafluoride Thalamus - blood supply Time Factors Transcranial color-coded sonography Ultrasonography, Doppler, Color - adverse effects Ultrasonography, Doppler, Color - methods Ultrasonography, Doppler, Transcranial - adverse effects Ultrasonography, Doppler, Transcranial - methods Ultrasound |
| title | Diagnostic Transcranial Ultrasound Perfusion-Imaging at 2.5 MHz Does Not Affect the Blood-Brain Barrier |
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