p53 is required for etoposide-induced apoptosis of human embryonic stem cells

The molecular mechanisms controlling DNA-damage-induced apoptosis of human embryonic stem cells (hESC) are poorly understood. Here we investigate the role of p53 in etoposide-induced apoptosis. We show that p53 is constitutively expressed at high levels in the cytoplasm of hESC. Etoposide treatment...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Stem cell research 2008-06, Vol.1 (2), p.116-128
Hauptverfasser:	Grandela, C., Pera, M.F., Wolvetang, E.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Apoptosis - drug effects Apoptosis Regulatory Proteins - genetics Cytoplasm - chemistry DNA Damage Embryonic Stem Cells - cytology Etoposide - pharmacology Gene Expression Regulation Humans Octamer Transcription Factor-3 - genetics Proto-Oncogene Proteins - genetics Tumor Suppressor Protein p53 - analysis Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!