Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells
Multiple tissue niches in the human body are now recognised to harbour stem cells. Here, we have asked how different adult stem cell populations, isolated from two ontogenetically distinct human organs (skin, pancreas), actually are with respect to a panel of standard markers/characteristics. Here w...
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| Veröffentlicht in: | European journal of cell biology 2008-01, Vol.87 (1), p.39-46 |
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| container_title | European journal of cell biology |
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| creator | Kajahn, Jennifer Gorjup, Erwin Tiede, Stephan von Briesen, Hagen Paus, Ralf Kruse, Charli Danner, Sandra |
| description | Multiple tissue niches in the human body are now recognised to harbour stem cells. Here, we have asked how different adult stem cell populations, isolated from two ontogenetically distinct human organs (skin, pancreas), actually are with respect to a panel of standard markers/characteristics. Here we show that an easily accessible adult human tissue such as skin may serve as a convenient source of adult stem cell-like populations that share markers with stem cells derived from an internal, exocrine organ. Surprisingly, both, human pancreas- and skin-derived stem/progenitor cells demonstrate differentiation patterns across lineage boundaries into cell types of ectoderm (e.g. PGP 9.5+ and GFAP+), mesoderm (e.g.
α-SMA+) and entoderm (e.g. amylase+ and albumin+). This intriguing differentiation capability warrants systemic follow-up, since it raises the theoretical possibility that an adult human skin-derived progenitor cell population could be envisioned for possible application in cell replacement therapies. |
| doi_str_mv | 10.1016/j.ejcb.2007.07.004 |
| format | Article |
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α-SMA+) and entoderm (e.g. amylase+ and albumin+). This intriguing differentiation capability warrants systemic follow-up, since it raises the theoretical possibility that an adult human skin-derived progenitor cell population could be envisioned for possible application in cell replacement therapies.</description><subject>Antigens, Differentiation - metabolism</subject><subject>Cell Differentiation - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Organ Specificity - physiology</subject><subject>Pancreas</subject><subject>Pancreas - cytology</subject><subject>Pancreas - metabolism</subject><subject>Plasticity</subject><subject>Skin</subject><subject>Skin - cytology</subject><subject>Skin - metabolism</subject><subject>Stem Cell Transplantation</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><issn>0171-9335</issn><issn>1618-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMouq5-AQ-Sk7euk6bZpOBFxH8geFDPIU0mbta2uyatst_ell3QkzAwMPzeY94j5IzBjAGbXy5nuLTVLAeQs3Gg2CMTNmcqY3mp9skEmGRZybk4IscpLQGYUGV5SI6YVIqB4hOCLx-hzRzG8IWOLvrGtNS4vu5o6rChFus60dTHdQwptO_1hqaFiUgHbkM9mq6PmOh36BY78dq0Ng73YP84nJADb-qEp7s9JW93t683D9nT8_3jzfVTZrkouqwE8CX3Dkonhc2RCSw8L4tK2qKyosiNzLkFqYTyzijLGHoPlTLez0XOOZ-Si63vOq4-e0ydbkIaPzAtrvqkJbBCCZADmG9BG1cpRfR6CNiYuNEM9FiuXuqxXD2Wq8eBYhCd79z7qkH3K9m1OQBXWwCHjF8Bo042YGvRhYi2024V_vP_AY_WjMc</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Kajahn, Jennifer</creator><creator>Gorjup, Erwin</creator><creator>Tiede, Stephan</creator><creator>von Briesen, Hagen</creator><creator>Paus, Ralf</creator><creator>Kruse, Charli</creator><creator>Danner, Sandra</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells</title><author>Kajahn, Jennifer ; Gorjup, Erwin ; Tiede, Stephan ; von Briesen, Hagen ; Paus, Ralf ; Kruse, Charli ; Danner, Sandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-900f93fd09d75c2e15e4f394b7c4bc542a723c07858fda8c11eff0b8aff652333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antigens, Differentiation - metabolism</topic><topic>Cell Differentiation - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Organ Specificity - physiology</topic><topic>Pancreas</topic><topic>Pancreas - cytology</topic><topic>Pancreas - metabolism</topic><topic>Plasticity</topic><topic>Skin</topic><topic>Skin - cytology</topic><topic>Skin - metabolism</topic><topic>Stem Cell Transplantation</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kajahn, Jennifer</creatorcontrib><creatorcontrib>Gorjup, Erwin</creatorcontrib><creatorcontrib>Tiede, Stephan</creatorcontrib><creatorcontrib>von Briesen, Hagen</creatorcontrib><creatorcontrib>Paus, Ralf</creatorcontrib><creatorcontrib>Kruse, Charli</creatorcontrib><creatorcontrib>Danner, Sandra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kajahn, Jennifer</au><au>Gorjup, Erwin</au><au>Tiede, Stephan</au><au>von Briesen, Hagen</au><au>Paus, Ralf</au><au>Kruse, Charli</au><au>Danner, Sandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells</atitle><jtitle>European journal of cell biology</jtitle><addtitle>Eur J Cell Biol</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>87</volume><issue>1</issue><spage>39</spage><epage>46</epage><pages>39-46</pages><issn>0171-9335</issn><eissn>1618-1298</eissn><abstract>Multiple tissue niches in the human body are now recognised to harbour stem cells. 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| fulltext | fulltext |
| identifier | ISSN: 0171-9335 |
| ispartof | European journal of cell biology, 2008-01, Vol.87 (1), p.39-46 |
| issn | 0171-9335 1618-1298 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Antigens, Differentiation - metabolism Cell Differentiation - physiology Female Humans Middle Aged Organ Specificity - physiology Pancreas Pancreas - cytology Pancreas - metabolism Plasticity Skin Skin - cytology Skin - metabolism Stem Cell Transplantation Stem cells Stem Cells - cytology Stem Cells - metabolism |
| title | Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells |
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