In Vivo Reprogramming of hTERT by Trans-splicing Ribozyme to Target Tumor Cells

We have developed and validated a new tumor-targeting gene therapy strategy based upon the targeting and replacement of human telomerase reverse transcriptase (hTERT) RNA, using a trans-splicing ribozyme. By constructing novel adenoviral vectors harboring the hTERT-targeting trans-splicing ribozymes...

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Veröffentlicht in:	Molecular therapy 2008-01, Vol.16 (1), p.74-80
Hauptverfasser:	Hong, Seung-Hee, Jeong, Jin-Sook, Lee, Yoon-Jong, Jung, Haeng-Im, Cho, Kyoung-Sook, Kim, Chang-Min, Kwon, Byung-Su, Sullenger, Bruce A, Lee, Seong-Wook, Kim, In-Hoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviruses Animals Cancer therapies Cell Line, Transformed Cell Line, Tumor Cytotoxicity Female Gene expression Gene Expression Regulation, Neoplastic - physiology Gene Targeting Gene therapy Genetic Vectors - administration & dosage HT29 Cells Humans Infections Male Mice Mice, Inbred BALB C Mice, Nude Molecular biology Peritoneal Neoplasms - enzymology Peritoneal Neoplasms - genetics Peritoneal Neoplasms - therapy Polymerase chain reaction RNA, Catalytic - genetics RNA, Catalytic - metabolism Telomerase Telomerase - biosynthesis Telomerase - genetics Telomerase - metabolism Trans-Splicing - genetics Transgenes Tumors
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