Intranasal immunization with Naegleria fowleri lysates and Cry1Ac induces metaplasia in the olfactory epithelium and increases IgA secretion

According to previous reports, intranasal administration of the Cry1Ac protein alone or with amoebic lysates increases protection against Naegleria fowleri meningoencephalitis in mice, apparently by eliciting IgA responses in the nasal mucosa. In the current study, we performed an immunohistochemica...

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Veröffentlicht in:	Parasite immunology 2008, Vol.30 (1), p.31-38
Hauptverfasser:	JARILLO-LUNA, A, MORENO-FIERROS, L, CAMPOS-RODRÍGUEZ, R, RODRÍGUEZ-MONROY, M.A, LARA-PADILLA, E, ROJAS-HERNÁNDEZ, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Administration, Intranasal Amebiasis - immunology Amebiasis - parasitology Animals Antibodies, Protozoan - analysis Antigens, Protozoan - immunology Bacterial Proteins - immunology Bacterial Toxins - immunology Endotoxins - immunology Hemolysin Proteins - immunology IgA Immunization Immunoglobulin A, Secretory - analysis Male Meningoencephalitis - immunology Meningoencephalitis - parasitology Metaplasia Mice Mice, Inbred BALB C Naegleria fowleri Naegleria fowleri - immunology Nasal mucosa Nasal Mucosa - immunology Nasal Mucosa - parasitology Olfactory Mucosa - immunology Recombinant Proteins - immunology
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