Characterization of the Human Cytochrome P450 Forms Involved in Metabolism of Tamoxifen to Its α-Hydroxy and α,4-Dihydroxy Derivatives

Tamoxifen is a known hepatocarcinogen in rats and is associated with an increased incidence of endometrial cancer in patients. One mechanism for these actions is via bioactivation, where reactive metabolites are generated that are capable of binding to DNA or protein. Several metabolites of tamoxife...

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Veröffentlicht in:	Chemical research in toxicology 2005-10, Vol.18 (10), p.1611-1618
Hauptverfasser:	Notley, L. M, Crewe, K. H, Taylor, P. J, Lennard, M. S, Gillam, E. M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Hormonal - metabolism Aryl Hydrocarbon Hydroxylases - metabolism Cytochrome P-450 CYP2B6 Cytochrome P-450 CYP2C9 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - metabolism Humans Microsomes, Liver - metabolism Oxidoreductases, N-Demethylating - metabolism Recombinant Proteins - metabolism Tamoxifen - analogs & derivatives Tamoxifen - metabolism
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