Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and a1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia

Background and Purpose : ALL is the most common pediatric cancer. The causes of the majority of pediatric acute leukemia are unknown and are likely to involve an interaction between genetic and environmental factors. Therefore, unfavourable gene-environmental interactions might be involved in the ge...

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Veröffentlicht in:	Journal of Egyptian National Cancer Institute 2007-06, Vol.19 (2), p.96-105
Hauptverfasser:	Kamil, Azzah, Musa, Hibah S., Ubayd, Jamal T., Bu, Rong R., Bhatia, Kishor G.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics Adolescent Case-Control Studies Child Child, Preschool DNA Mutational Analysis DNA, Neoplasm - genetics Female Genetic polymorphisms Genotype Heterozygote Homozygote Humans Leukemia in children Lymphoblastic leukemia in children Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Polymerase Chain Reaction Polymorphism, Genetic - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Retrospective Studies Risk Factors ابيضاض الدم الليمفاوي الحاد الأطفال السرطان سرطان الدم
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