Immunohistochemical expression of bcl-2 in Dukes' stage B and C colorectal carcinoma patients: correlation with p53 and ki-67 in evaluating prognostic significance
The objective of this study was to evaluate the expression of bcl-2 in Dukes' stage B and stage C (AJCC/UICC stage I and III) colorectal adenocarcinomas and to examine its association with clinicopathological features, p53, ki-67 and long term outcome. Paraffin embedded specimens from 61 patien...
Gespeichert in:
| Veröffentlicht in: | Polish journal of pathology 2005, Vol.56 (4), p.179-185 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 185 |
|---|---|
| container_issue | 4 |
| container_start_page | 179 |
| container_title | Polish journal of pathology |
| container_volume | 56 |
| creator | Zavrides, Harris Zizi-Sermpetzoglou, Adamantia Elemenoglou, Ioannis Papatheofanis, Ioannis Peros, Georgios Athanasas, Georgios Panousopoulos, Dimitrios |
| description | The objective of this study was to evaluate the expression of bcl-2 in Dukes' stage B and stage C (AJCC/UICC stage I and III) colorectal adenocarcinomas and to examine its association with clinicopathological features, p53, ki-67 and long term outcome. Paraffin embedded specimens from 61 patients with Dukes' stage B (AJCC/UICC stage I) and 39 patients with Dukes' stage C (AJCC/UICC stage III) colorectal adenocarcinoma who were treated with surgery were assessed. We used immunohistochemistry to determine the expression of bcl-2, p53 and ki-67 with a five-year follow-up. Positive bcl-2 expression was seen in 27 cases (27%). Expression of bcl-2 protein was related to tumor stage (p=0.0117). There was very strong evidence of an association between bcl-2 staining and ki-67 score (p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70136807</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70136807</sourcerecordid><originalsourceid>FETCH-LOGICAL-p124t-d1dab74edf7782dfacbab81da445bda689ab1b584a4985bcdd62a1018ee5ff633</originalsourceid><addsrcrecordid>eNo1UMtOwzAQzAFEq9JfQD7BKVKch51yg_KqVIkLnKO1vUlNHTvEDo_v4UcxUPay2tmZ0eweJXOaF0W6YjWfJUvvX7JYLMs5K06SGWUl5zXn8-Rr0_eTdTvtg5M77LUEQ_BjGNF77SxxLRHSpDnRltxMe_QXxAfokFwTsIqsiXTGjShDlEkYpbauBzJA0GiDv4zrcUQTx-j1rsOODFXxq9zrlPEfV3wDM0WC7cgwus46H7QkXndWtzGNlXiaHLdgPC4PfZE8390-rR_S7eP9Zn21TQealyFVVIHgJao23parFqQAUUewLCuhgNUrEFRUdQnlqq6EVIrlQDNaI1Zty4pikZz_-cYcrxP60PTaSzQGLLrJNzyjBaszHolnB-IkelTNMOoexs_m_63FN-d1d3o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70136807</pqid></control><display><type>article</type><title>Immunohistochemical expression of bcl-2 in Dukes' stage B and C colorectal carcinoma patients: correlation with p53 and ki-67 in evaluating prognostic significance</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Zavrides, Harris ; Zizi-Sermpetzoglou, Adamantia ; Elemenoglou, Ioannis ; Papatheofanis, Ioannis ; Peros, Georgios ; Athanasas, Georgios ; Panousopoulos, Dimitrios</creator><creatorcontrib>Zavrides, Harris ; Zizi-Sermpetzoglou, Adamantia ; Elemenoglou, Ioannis ; Papatheofanis, Ioannis ; Peros, Georgios ; Athanasas, Georgios ; Panousopoulos, Dimitrios</creatorcontrib><description>The objective of this study was to evaluate the expression of bcl-2 in Dukes' stage B and stage C (AJCC/UICC stage I and III) colorectal adenocarcinomas and to examine its association with clinicopathological features, p53, ki-67 and long term outcome. Paraffin embedded specimens from 61 patients with Dukes' stage B (AJCC/UICC stage I) and 39 patients with Dukes' stage C (AJCC/UICC stage III) colorectal adenocarcinoma who were treated with surgery were assessed. We used immunohistochemistry to determine the expression of bcl-2, p53 and ki-67 with a five-year follow-up. Positive bcl-2 expression was seen in 27 cases (27%). Expression of bcl-2 protein was related to tumor stage (p=0.0117). There was very strong evidence of an association between bcl-2 staining and ki-67 score (p<0.001). There was a trend towards increased survival in patients whose tumors expressed bcl-2 protein (p=0.001). When entered into a multivariate analysis model, which also included p53 and stage, bcl-2 staining emerged as a prognostic indicator variable. Expression of bcl-2 appears to be useful in selecting a group of colorectal cancer patients with a better prognosis.</description><identifier>ISSN: 1233-9687</identifier><identifier>PMID: 16477877</identifier><language>eng</language><publisher>Poland</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Aged ; Biomarkers, Tumor - metabolism ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Female ; Humans ; Immunoenzyme Techniques ; Ki-67 Antigen - metabolism ; Male ; Prognosis ; Proportional Hazards Models ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Survival Rate ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Polish journal of pathology, 2005, Vol.56 (4), p.179-185</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16477877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zavrides, Harris</creatorcontrib><creatorcontrib>Zizi-Sermpetzoglou, Adamantia</creatorcontrib><creatorcontrib>Elemenoglou, Ioannis</creatorcontrib><creatorcontrib>Papatheofanis, Ioannis</creatorcontrib><creatorcontrib>Peros, Georgios</creatorcontrib><creatorcontrib>Athanasas, Georgios</creatorcontrib><creatorcontrib>Panousopoulos, Dimitrios</creatorcontrib><title>Immunohistochemical expression of bcl-2 in Dukes' stage B and C colorectal carcinoma patients: correlation with p53 and ki-67 in evaluating prognostic significance</title><title>Polish journal of pathology</title><addtitle>Pol J Pathol</addtitle><description>The objective of this study was to evaluate the expression of bcl-2 in Dukes' stage B and stage C (AJCC/UICC stage I and III) colorectal adenocarcinomas and to examine its association with clinicopathological features, p53, ki-67 and long term outcome. Paraffin embedded specimens from 61 patients with Dukes' stage B (AJCC/UICC stage I) and 39 patients with Dukes' stage C (AJCC/UICC stage III) colorectal adenocarcinoma who were treated with surgery were assessed. We used immunohistochemistry to determine the expression of bcl-2, p53 and ki-67 with a five-year follow-up. Positive bcl-2 expression was seen in 27 cases (27%). Expression of bcl-2 protein was related to tumor stage (p=0.0117). There was very strong evidence of an association between bcl-2 staining and ki-67 score (p<0.001). There was a trend towards increased survival in patients whose tumors expressed bcl-2 protein (p=0.001). When entered into a multivariate analysis model, which also included p53 and stage, bcl-2 staining emerged as a prognostic indicator variable. Expression of bcl-2 appears to be useful in selecting a group of colorectal cancer patients with a better prognosis.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Male</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Survival Rate</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>1233-9687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UMtOwzAQzAFEq9JfQD7BKVKch51yg_KqVIkLnKO1vUlNHTvEDo_v4UcxUPay2tmZ0eweJXOaF0W6YjWfJUvvX7JYLMs5K06SGWUl5zXn8-Rr0_eTdTvtg5M77LUEQ_BjGNF77SxxLRHSpDnRltxMe_QXxAfokFwTsIqsiXTGjShDlEkYpbauBzJA0GiDv4zrcUQTx-j1rsOODFXxq9zrlPEfV3wDM0WC7cgwus46H7QkXndWtzGNlXiaHLdgPC4PfZE8390-rR_S7eP9Zn21TQealyFVVIHgJao23parFqQAUUewLCuhgNUrEFRUdQnlqq6EVIrlQDNaI1Zty4pikZz_-cYcrxP60PTaSzQGLLrJNzyjBaszHolnB-IkelTNMOoexs_m_63FN-d1d3o</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Zavrides, Harris</creator><creator>Zizi-Sermpetzoglou, Adamantia</creator><creator>Elemenoglou, Ioannis</creator><creator>Papatheofanis, Ioannis</creator><creator>Peros, Georgios</creator><creator>Athanasas, Georgios</creator><creator>Panousopoulos, Dimitrios</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Immunohistochemical expression of bcl-2 in Dukes' stage B and C colorectal carcinoma patients: correlation with p53 and ki-67 in evaluating prognostic significance</title><author>Zavrides, Harris ; Zizi-Sermpetzoglou, Adamantia ; Elemenoglou, Ioannis ; Papatheofanis, Ioannis ; Peros, Georgios ; Athanasas, Georgios ; Panousopoulos, Dimitrios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-d1dab74edf7782dfacbab81da445bda689ab1b584a4985bcdd62a1018ee5ff633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Male</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>Survival Rate</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zavrides, Harris</creatorcontrib><creatorcontrib>Zizi-Sermpetzoglou, Adamantia</creatorcontrib><creatorcontrib>Elemenoglou, Ioannis</creatorcontrib><creatorcontrib>Papatheofanis, Ioannis</creatorcontrib><creatorcontrib>Peros, Georgios</creatorcontrib><creatorcontrib>Athanasas, Georgios</creatorcontrib><creatorcontrib>Panousopoulos, Dimitrios</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Polish journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zavrides, Harris</au><au>Zizi-Sermpetzoglou, Adamantia</au><au>Elemenoglou, Ioannis</au><au>Papatheofanis, Ioannis</au><au>Peros, Georgios</au><au>Athanasas, Georgios</au><au>Panousopoulos, Dimitrios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical expression of bcl-2 in Dukes' stage B and C colorectal carcinoma patients: correlation with p53 and ki-67 in evaluating prognostic significance</atitle><jtitle>Polish journal of pathology</jtitle><addtitle>Pol J Pathol</addtitle><date>2005</date><risdate>2005</risdate><volume>56</volume><issue>4</issue><spage>179</spage><epage>185</epage><pages>179-185</pages><issn>1233-9687</issn><abstract>The objective of this study was to evaluate the expression of bcl-2 in Dukes' stage B and stage C (AJCC/UICC stage I and III) colorectal adenocarcinomas and to examine its association with clinicopathological features, p53, ki-67 and long term outcome. Paraffin embedded specimens from 61 patients with Dukes' stage B (AJCC/UICC stage I) and 39 patients with Dukes' stage C (AJCC/UICC stage III) colorectal adenocarcinoma who were treated with surgery were assessed. We used immunohistochemistry to determine the expression of bcl-2, p53 and ki-67 with a five-year follow-up. Positive bcl-2 expression was seen in 27 cases (27%). Expression of bcl-2 protein was related to tumor stage (p=0.0117). There was very strong evidence of an association between bcl-2 staining and ki-67 score (p<0.001). There was a trend towards increased survival in patients whose tumors expressed bcl-2 protein (p=0.001). When entered into a multivariate analysis model, which also included p53 and stage, bcl-2 staining emerged as a prognostic indicator variable. Expression of bcl-2 appears to be useful in selecting a group of colorectal cancer patients with a better prognosis.</abstract><cop>Poland</cop><pmid>16477877</pmid><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1233-9687 |
| ispartof | Polish journal of pathology, 2005, Vol.56 (4), p.179-185 |
| issn | 1233-9687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70136807 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology Aged Biomarkers, Tumor - metabolism Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Female Humans Immunoenzyme Techniques Ki-67 Antigen - metabolism Male Prognosis Proportional Hazards Models Proto-Oncogene Proteins c-bcl-2 - metabolism Survival Rate Tumor Suppressor Protein p53 - metabolism |
| title | Immunohistochemical expression of bcl-2 in Dukes' stage B and C colorectal carcinoma patients: correlation with p53 and ki-67 in evaluating prognostic significance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T23%3A55%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunohistochemical%20expression%20of%20bcl-2%20in%20Dukes'%20stage%20B%20and%20C%20colorectal%20carcinoma%20patients:%20correlation%20with%20p53%20and%20ki-67%20in%20evaluating%20prognostic%20significance&rft.jtitle=Polish%20journal%20of%20pathology&rft.au=Zavrides,%20Harris&rft.date=2005&rft.volume=56&rft.issue=4&rft.spage=179&rft.epage=185&rft.pages=179-185&rft.issn=1233-9687&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E70136807%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70136807&rft_id=info:pmid/16477877&rfr_iscdi=true |