Langerhans cells do not express alternative macrophage activation-associated CC chemokine (AMAC)-1
We have cloned a novel human CC chemokine, alternative macrophage activation-associated CC chemokine (AMAC)-1 that is highly homologous to macrophage inflammatory protein (MIP)-1α. In contrast to MIP-1α, AMAC-1 is induced in macrophages by Th2-associated cytokines IL4, IL13, and IL10 in vitro; in ad...
Gespeichert in:
| Veröffentlicht in: | Research in immunology (Paris) 1998-09, Vol.149 (7), p.633-637 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 637 |
|---|---|
| container_issue | 7 |
| container_start_page | 633 |
| container_title | Research in immunology (Paris) |
| container_volume | 149 |
| creator | Kodelja, V. Kraft, S. Politz, O. Hakij, N. Treudler, R. Orfanos, C.E. Bieber, T. Goerdt, S. |
| description | We have cloned a novel human CC chemokine, alternative macrophage activation-associated CC chemokine (AMAC)-1 that is highly homologous to macrophage inflammatory protein (MIP)-1α. In contrast to MIP-1α, AMAC-1 is induced in macrophages by Th2-associated cytokines IL4, IL13, and IL10
in vitro; in addition, AMAC-1 is expressed by Th1-suppressive alveolar macrophages
in vivo. Surprisingly, however, AMAC-1 is also expressed by GM-CSF-induced,
in vitro monocyte-derived dendritic cells when treated by IL4. Here, we present a detailed analysis of AMAC-1 expression in monocyte-derived dendritic cells
in vitro and show that the prime dendritic cells
in vivo, i.e. epidermal Langerhans cells, do not express AMAC-1 mRIMA. In conclusion, AMAC-1 is a novel CC chemokine whose Th2-associated expression pattern in alternatively activated suppressor macrophages
in vivo and
in vitro and its absence from epidermal Langerhans cells
in vivo suggest that it may be involved in inhibition of Th1 reactions and in tolerance induction. |
| doi_str_mv | 10.1016/S0923-2494(99)80029-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70136111</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0923249499800297</els_id><sourcerecordid>17147277</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-d342b66229db79a9df3a108e7515ddc869005c72f6dd84368eed004ab1c34cb43</originalsourceid><addsrcrecordid>eNqFkE9P3DAQxX1oRSn0IyD5UFVwCNiON45PaBWVP9IiDm3P1sSesIbEXuwsar89CbuiR04jvXnzZuZHyAln55zx6uIX06IshNTyVOuzmjGhC_WJHL7LX8jXnB8Z44orcUAOdL3gCy4PSbuC8IBpDSFTi32fqYs0xJHi303CnCn0I6YAo39BOoBNcbOGB6RgJ2VSYygg52g9jOho01C7xiE--YD0dHm3bM4Kfkw-d9Bn_LavR-TP1c_fzU2xur--bZarwkrBxsKVUrRVJYR2rdKgXVcCZzWq6VLnbF1pxhZWia5yrpZlVSM6xiS03JbStrI8Ij92uZsUn7eYRzP4PP8EAeM2G8V4WXHOPzROkKQSSk3Gxc44vZ1zws5skh8g_TOcmRm8eQNvZsJGa_MG3sxzJ_sF23ZA9z61pz71v-_7kC30XYJgff4fXnEm2RxzubPhRO3FYzLZegwWnU9oR-Oi_-CQV7FSoN8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17147277</pqid></control><display><type>article</type><title>Langerhans cells do not express alternative macrophage activation-associated CC chemokine (AMAC)-1</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kodelja, V. ; Kraft, S. ; Politz, O. ; Hakij, N. ; Treudler, R. ; Orfanos, C.E. ; Bieber, T. ; Goerdt, S.</creator><contributor>Bartholeyns, J</contributor><creatorcontrib>Kodelja, V. ; Kraft, S. ; Politz, O. ; Hakij, N. ; Treudler, R. ; Orfanos, C.E. ; Bieber, T. ; Goerdt, S. ; Bartholeyns, J</creatorcontrib><description>We have cloned a novel human CC chemokine, alternative macrophage activation-associated CC chemokine (AMAC)-1 that is highly homologous to macrophage inflammatory protein (MIP)-1α. In contrast to MIP-1α, AMAC-1 is induced in macrophages by Th2-associated cytokines IL4, IL13, and IL10
in vitro; in addition, AMAC-1 is expressed by Th1-suppressive alveolar macrophages
in vivo. Surprisingly, however, AMAC-1 is also expressed by GM-CSF-induced,
in vitro monocyte-derived dendritic cells when treated by IL4. Here, we present a detailed analysis of AMAC-1 expression in monocyte-derived dendritic cells
in vitro and show that the prime dendritic cells
in vivo, i.e. epidermal Langerhans cells, do not express AMAC-1 mRIMA. In conclusion, AMAC-1 is a novel CC chemokine whose Th2-associated expression pattern in alternatively activated suppressor macrophages
in vivo and
in vitro and its absence from epidermal Langerhans cells
in vivo suggest that it may be involved in inhibition of Th1 reactions and in tolerance induction.</description><identifier>ISSN: 0923-2494</identifier><identifier>DOI: 10.1016/S0923-2494(99)80029-7</identifier><identifier>PMID: 9851514</identifier><language>eng</language><publisher>Paris: Elsevier B.V</publisher><subject>AIDS/HIV ; AMAC-1 chemokine ; Analysis of the immune response. Humoral and cellular immunity ; Biological and medical sciences ; Chemokines, CC - biosynthesis ; Chemokines, CC - genetics ; Cytokines - immunology ; Cytokines - pharmacology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gene Expression - drug effects ; Humans ; Immunobiology ; Langerhans cell ; Langerhans Cells - drug effects ; Langerhans Cells - immunology ; Lymphokines, interleukins ( function, expression) ; Macrophage ; Macrophage Activation - immunology ; Macrophages - drug effects ; Macrophages - immunology ; Mitogens - immunology ; Mitogens - pharmacology ; Regulatory factors and their cellular receptors ; Th2 Cells - immunology</subject><ispartof>Research in immunology (Paris), 1998-09, Vol.149 (7), p.633-637</ispartof><rights>1998 Institut Pasteur/Elsevier Paris</rights><rights>1999 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-d342b66229db79a9df3a108e7515ddc869005c72f6dd84368eed004ab1c34cb43</citedby><cites>FETCH-LOGICAL-c420t-d342b66229db79a9df3a108e7515ddc869005c72f6dd84368eed004ab1c34cb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,777,781,786,787,23911,23912,25121,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1610407$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9851514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bartholeyns, J</contributor><creatorcontrib>Kodelja, V.</creatorcontrib><creatorcontrib>Kraft, S.</creatorcontrib><creatorcontrib>Politz, O.</creatorcontrib><creatorcontrib>Hakij, N.</creatorcontrib><creatorcontrib>Treudler, R.</creatorcontrib><creatorcontrib>Orfanos, C.E.</creatorcontrib><creatorcontrib>Bieber, T.</creatorcontrib><creatorcontrib>Goerdt, S.</creatorcontrib><title>Langerhans cells do not express alternative macrophage activation-associated CC chemokine (AMAC)-1</title><title>Research in immunology (Paris)</title><addtitle>Res Immunol</addtitle><description>We have cloned a novel human CC chemokine, alternative macrophage activation-associated CC chemokine (AMAC)-1 that is highly homologous to macrophage inflammatory protein (MIP)-1α. In contrast to MIP-1α, AMAC-1 is induced in macrophages by Th2-associated cytokines IL4, IL13, and IL10
in vitro; in addition, AMAC-1 is expressed by Th1-suppressive alveolar macrophages
in vivo. Surprisingly, however, AMAC-1 is also expressed by GM-CSF-induced,
in vitro monocyte-derived dendritic cells when treated by IL4. Here, we present a detailed analysis of AMAC-1 expression in monocyte-derived dendritic cells
in vitro and show that the prime dendritic cells
in vivo, i.e. epidermal Langerhans cells, do not express AMAC-1 mRIMA. In conclusion, AMAC-1 is a novel CC chemokine whose Th2-associated expression pattern in alternatively activated suppressor macrophages
in vivo and
in vitro and its absence from epidermal Langerhans cells
in vivo suggest that it may be involved in inhibition of Th1 reactions and in tolerance induction.</description><subject>AIDS/HIV</subject><subject>AMAC-1 chemokine</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Biological and medical sciences</subject><subject>Chemokines, CC - biosynthesis</subject><subject>Chemokines, CC - genetics</subject><subject>Cytokines - immunology</subject><subject>Cytokines - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gene Expression - drug effects</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Langerhans cell</subject><subject>Langerhans Cells - drug effects</subject><subject>Langerhans Cells - immunology</subject><subject>Lymphokines, interleukins ( function, expression)</subject><subject>Macrophage</subject><subject>Macrophage Activation - immunology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - immunology</subject><subject>Mitogens - immunology</subject><subject>Mitogens - pharmacology</subject><subject>Regulatory factors and their cellular receptors</subject><subject>Th2 Cells - immunology</subject><issn>0923-2494</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9P3DAQxX1oRSn0IyD5UFVwCNiON45PaBWVP9IiDm3P1sSesIbEXuwsar89CbuiR04jvXnzZuZHyAln55zx6uIX06IshNTyVOuzmjGhC_WJHL7LX8jXnB8Z44orcUAOdL3gCy4PSbuC8IBpDSFTi32fqYs0xJHi303CnCn0I6YAo39BOoBNcbOGB6RgJ2VSYygg52g9jOho01C7xiE--YD0dHm3bM4Kfkw-d9Bn_LavR-TP1c_fzU2xur--bZarwkrBxsKVUrRVJYR2rdKgXVcCZzWq6VLnbF1pxhZWia5yrpZlVSM6xiS03JbStrI8Ij92uZsUn7eYRzP4PP8EAeM2G8V4WXHOPzROkKQSSk3Gxc44vZ1zws5skh8g_TOcmRm8eQNvZsJGa_MG3sxzJ_sF23ZA9z61pz71v-_7kC30XYJgff4fXnEm2RxzubPhRO3FYzLZegwWnU9oR-Oi_-CQV7FSoN8</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>Kodelja, V.</creator><creator>Kraft, S.</creator><creator>Politz, O.</creator><creator>Hakij, N.</creator><creator>Treudler, R.</creator><creator>Orfanos, C.E.</creator><creator>Bieber, T.</creator><creator>Goerdt, S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980901</creationdate><title>Langerhans cells do not express alternative macrophage activation-associated CC chemokine (AMAC)-1</title><author>Kodelja, V. ; Kraft, S. ; Politz, O. ; Hakij, N. ; Treudler, R. ; Orfanos, C.E. ; Bieber, T. ; Goerdt, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-d342b66229db79a9df3a108e7515ddc869005c72f6dd84368eed004ab1c34cb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>AIDS/HIV</topic><topic>AMAC-1 chemokine</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Biological and medical sciences</topic><topic>Chemokines, CC - biosynthesis</topic><topic>Chemokines, CC - genetics</topic><topic>Cytokines - immunology</topic><topic>Cytokines - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gene Expression - drug effects</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Langerhans cell</topic><topic>Langerhans Cells - drug effects</topic><topic>Langerhans Cells - immunology</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>Macrophage</topic><topic>Macrophage Activation - immunology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - immunology</topic><topic>Mitogens - immunology</topic><topic>Mitogens - pharmacology</topic><topic>Regulatory factors and their cellular receptors</topic><topic>Th2 Cells - immunology</topic><toplevel>online_resources</toplevel><creatorcontrib>Kodelja, V.</creatorcontrib><creatorcontrib>Kraft, S.</creatorcontrib><creatorcontrib>Politz, O.</creatorcontrib><creatorcontrib>Hakij, N.</creatorcontrib><creatorcontrib>Treudler, R.</creatorcontrib><creatorcontrib>Orfanos, C.E.</creatorcontrib><creatorcontrib>Bieber, T.</creatorcontrib><creatorcontrib>Goerdt, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Research in immunology (Paris)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kodelja, V.</au><au>Kraft, S.</au><au>Politz, O.</au><au>Hakij, N.</au><au>Treudler, R.</au><au>Orfanos, C.E.</au><au>Bieber, T.</au><au>Goerdt, S.</au><au>Bartholeyns, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Langerhans cells do not express alternative macrophage activation-associated CC chemokine (AMAC)-1</atitle><jtitle>Research in immunology (Paris)</jtitle><addtitle>Res Immunol</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>149</volume><issue>7</issue><spage>633</spage><epage>637</epage><pages>633-637</pages><issn>0923-2494</issn><abstract>We have cloned a novel human CC chemokine, alternative macrophage activation-associated CC chemokine (AMAC)-1 that is highly homologous to macrophage inflammatory protein (MIP)-1α. In contrast to MIP-1α, AMAC-1 is induced in macrophages by Th2-associated cytokines IL4, IL13, and IL10
in vitro; in addition, AMAC-1 is expressed by Th1-suppressive alveolar macrophages
in vivo. Surprisingly, however, AMAC-1 is also expressed by GM-CSF-induced,
in vitro monocyte-derived dendritic cells when treated by IL4. Here, we present a detailed analysis of AMAC-1 expression in monocyte-derived dendritic cells
in vitro and show that the prime dendritic cells
in vivo, i.e. epidermal Langerhans cells, do not express AMAC-1 mRIMA. In conclusion, AMAC-1 is a novel CC chemokine whose Th2-associated expression pattern in alternatively activated suppressor macrophages
in vivo and
in vitro and its absence from epidermal Langerhans cells
in vivo suggest that it may be involved in inhibition of Th1 reactions and in tolerance induction.</abstract><cop>Paris</cop><pub>Elsevier B.V</pub><pmid>9851514</pmid><doi>10.1016/S0923-2494(99)80029-7</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0923-2494 |
| ispartof | Research in immunology (Paris), 1998-09, Vol.149 (7), p.633-637 |
| issn | 0923-2494 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70136111 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS/HIV AMAC-1 chemokine Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Chemokines, CC - biosynthesis Chemokines, CC - genetics Cytokines - immunology Cytokines - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression - drug effects Humans Immunobiology Langerhans cell Langerhans Cells - drug effects Langerhans Cells - immunology Lymphokines, interleukins ( function, expression) Macrophage Macrophage Activation - immunology Macrophages - drug effects Macrophages - immunology Mitogens - immunology Mitogens - pharmacology Regulatory factors and their cellular receptors Th2 Cells - immunology |
| title | Langerhans cells do not express alternative macrophage activation-associated CC chemokine (AMAC)-1 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T02%3A28%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Langerhans%20cells%20do%20not%20express%20alternative%20macrophage%20activation-associated%20CC%20chemokine%20(AMAC)-1&rft.jtitle=Research%20in%20immunology%20(Paris)&rft.au=Kodelja,%20V.&rft.date=1998-09-01&rft.volume=149&rft.issue=7&rft.spage=633&rft.epage=637&rft.pages=633-637&rft.issn=0923-2494&rft_id=info:doi/10.1016/S0923-2494(99)80029-7&rft_dat=%3Cproquest_cross%3E17147277%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17147277&rft_id=info:pmid/9851514&rft_els_id=S0923249499800297&rfr_iscdi=true |