Oxidative status and citrate concentration in rat tissues during experimental hyperthyroidism and melatonin treatment
Biochemiluminescence increased, while aconitate hydratase activity and citrate accumulation in tissues of the liver and heart and blood decreased in rats with experimental hyperthyroidism. These changes reflect activation of free radical oxidation, damage to enzyme molecules with reactive oxygen spe...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2007-08, Vol.144 (2), p.203-206 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Popov, S S Pashkov, A N Popova, T N Zoloedov, V I Semenikhina, A V Rakhmanova, T I |
| description | Biochemiluminescence increased, while aconitate hydratase activity and citrate accumulation in tissues of the liver and heart and blood decreased in rats with experimental hyperthyroidism. These changes reflect activation of free radical oxidation, damage to enzyme molecules with reactive oxygen species, and impaired utilization of citrate under pathological conditions. Melatonin treatment during hyperthyroidism normalized aconitate hydratase activity and citrate concentration. Biochemiluminescence study showed that the effect of melatonin is related to antioxidant activity of this hormone, inhibition of free radical oxidation, and suppression of reactive oxygen species generation. |
| doi_str_mv | 10.1007/s10517-007-0289-2 |
| format | Article |
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These changes reflect activation of free radical oxidation, damage to enzyme molecules with reactive oxygen species, and impaired utilization of citrate under pathological conditions. Melatonin treatment during hyperthyroidism normalized aconitate hydratase activity and citrate concentration. 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| subjects | Aconitate Hydratase - metabolism Animals Antioxidants - pharmacology Citric Acid - blood Citric Acid - metabolism Hyperthyroidism - blood Hyperthyroidism - drug therapy Hyperthyroidism - metabolism Liver - metabolism Luminescence Male Melatonin - pharmacology Myocardium - metabolism Oxidation-Reduction Oxidative Stress - drug effects Rats |
| title | Oxidative status and citrate concentration in rat tissues during experimental hyperthyroidism and melatonin treatment |
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