Antidepressant-like effect of icariin and its possible mechanism in mice

The behavioral, neurochemical and neuroendocrine effects of icariin isolated from Epimedium brevicornum were investigated in behavioral despair models of KunMing strain of male mice. Icariin was found to significantly shorten immobility time in the forced swimming test (FST) after orally administrat...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2005-12, Vol.82 (4), p.686-694
Hauptverfasser:	Pan, Ying, Kong, Lingdong, Xia, Xing, Zhang, Weiyun, Xia, Zhonghao, Jiang, Fuxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Biological and medical sciences Brain - drug effects Brain - enzymology Brain - metabolism Corticotropin-releasing factor Epimedium brevicornum Flavonoids - pharmacology Forced swimming test Icariin Male Medical sciences Mice Monoamine neurotransmitters Monoamine oxidase Monoamine Oxidase - metabolism Neuropharmacology Neurotransmitter Agents - metabolism Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Stress, Physiological Swimming Tail suspension test
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