Adenosine and ADP prevent apoptosis in cultured rat cerebellar granule cells

Cerebellar granule cells (CGCs) explanted in vitro undergo death via apoptosis when the concentration of potassium is shifted from 25 mM to 5 mM. We report that adenosine and ADP, which act as neurotransmitters and neuromodulators in the brain, exert in cultured cerebellar granule cells a specific a...

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Veröffentlicht in:	Brain research 1998-11, Vol.809 (2), p.297-301
Hauptverfasser:	Vitolo, O.V., Ciotti, M.T., Galli, C., Borsello, T., Calissano, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine Diphosphate - pharmacology ADP Ageing, cell death Animals Apoptosis Apoptosis - drug effects Biological and medical sciences Cell physiology Cells, Cultured Cerebellar granule cell Cerebellum - cytology Fundamental and applied biological sciences. Psychology In Situ Nick-End Labeling Molecular and cellular biology Neurons - chemistry Neurons - cytology Neurons - metabolism Potassium Chloride - pharmacokinetics Purinoceptor Rats Rats, Wistar Receptors, Purinergic - physiology Xanthines - pharmacology
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