Microcapsules of alginate-chitosan – I: A quantitative study of the interaction between alginate and chitosan
The binding of chitosan to alginate beads was studied quantitatively by using radioactive labelled fractions of chitosan. The alginate-chitosan capsules were made either by dropping a solution of sodium alginate into a solution containing chitosan or by incubating calcium alginate beads in a solutio...
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| Veröffentlicht in: | Biomaterials 1998-10, Vol.19 (20), p.1815-1825 |
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| creator | Gåserød, Olav Smidsrød, Olav Skjåk-Bræk, Gudmund |
| description | The binding of chitosan to alginate beads was studied quantitatively by using radioactive labelled fractions of chitosan. The alginate-chitosan capsules were made either by dropping a solution of sodium alginate into a solution containing chitosan or by incubating calcium alginate beads in a solution of chitosan. The first procedure yielded a binding of 0.015
μg chitosan per mm
2 of capsule surface, while the latter procedure yielded over 2
μg
mm
-2. The maximum obtained weight ratio of chitosan to alginate in a microcapsule after 24
h was 0.40. The binding of chitosan was markedly increased by reducing the number average molecular weight of chitosan below 20000
Da and by increasing the porosity of the alginate gel. The porosity was increased by producing homogeneous gels, and by adding calcium chloride to the chitosan solution during the membrane forming stage. The effect of calcium ions on the porosity of the gel was studied by experiments involving release of blue dextran from calcium alginate beads. The binding of chitosan was also found to increase with decreasing fraction of N-acetylations,
F
A, on chitosan in the range of
F
A=0.3 to
F
A=0, and with increasing pH in the range from pH 4 to 6. Capsules with a diameter of 500
μm had a higher weight ratio of chitosan to alginate after 24
h of binding than the capsules with the larger diameter of 1500
μm. |
| doi_str_mv | 10.1016/S0142-9612(98)00073-8 |
| format | Article |
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μg chitosan per mm
2 of capsule surface, while the latter procedure yielded over 2
μg
mm
-2. The maximum obtained weight ratio of chitosan to alginate in a microcapsule after 24
h was 0.40. The binding of chitosan was markedly increased by reducing the number average molecular weight of chitosan below 20000
Da and by increasing the porosity of the alginate gel. The porosity was increased by producing homogeneous gels, and by adding calcium chloride to the chitosan solution during the membrane forming stage. The effect of calcium ions on the porosity of the gel was studied by experiments involving release of blue dextran from calcium alginate beads. The binding of chitosan was also found to increase with decreasing fraction of N-acetylations,
F
A, on chitosan in the range of
F
A=0.3 to
F
A=0, and with increasing pH in the range from pH 4 to 6. Capsules with a diameter of 500
μm had a higher weight ratio of chitosan to alginate after 24
h of binding than the capsules with the larger diameter of 1500
μm.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(98)00073-8</identifier><identifier>PMID: 9855182</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acetylation ; Alginate ; Alginates - chemistry ; Biocompatible Materials - chemistry ; Biological and medical sciences ; Calcium - chemistry ; Calcium compounds ; Capsules ; Cations - chemistry ; Chemistry, Pharmaceutical ; Chitin - analogs & derivatives ; Chitin - chemistry ; Chitosan ; Composition effects ; Gels ; Gels - chemistry ; General pharmacology ; Glucuronic Acid ; Hexuronic Acids ; Hydrogen-Ion Concentration ; Medical sciences ; Microcapsules ; Miscellaneous ; Molecular Weight ; Osmolar Concentration ; pH effects ; Pharmacology. Drug treatments ; Polymeric membranes ; Polysaccharides ; Porosity ; Sodium - chemistry ; Sodium compounds</subject><ispartof>Biomaterials, 1998-10, Vol.19 (20), p.1815-1825</ispartof><rights>1998</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-e54d03aee10aaad0471c5c19f68c3d1ed2144908176146977238b75b005e52e33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961298000738$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1597283$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9855182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gåserød, Olav</creatorcontrib><creatorcontrib>Smidsrød, Olav</creatorcontrib><creatorcontrib>Skjåk-Bræk, Gudmund</creatorcontrib><title>Microcapsules of alginate-chitosan – I: A quantitative study of the interaction between alginate and chitosan</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>The binding of chitosan to alginate beads was studied quantitatively by using radioactive labelled fractions of chitosan. The alginate-chitosan capsules were made either by dropping a solution of sodium alginate into a solution containing chitosan or by incubating calcium alginate beads in a solution of chitosan. The first procedure yielded a binding of 0.015
μg chitosan per mm
2 of capsule surface, while the latter procedure yielded over 2
μg
mm
-2. The maximum obtained weight ratio of chitosan to alginate in a microcapsule after 24
h was 0.40. The binding of chitosan was markedly increased by reducing the number average molecular weight of chitosan below 20000
Da and by increasing the porosity of the alginate gel. The porosity was increased by producing homogeneous gels, and by adding calcium chloride to the chitosan solution during the membrane forming stage. The effect of calcium ions on the porosity of the gel was studied by experiments involving release of blue dextran from calcium alginate beads. The binding of chitosan was also found to increase with decreasing fraction of N-acetylations,
F
A, on chitosan in the range of
F
A=0.3 to
F
A=0, and with increasing pH in the range from pH 4 to 6. Capsules with a diameter of 500
μm had a higher weight ratio of chitosan to alginate after 24
h of binding than the capsules with the larger diameter of 1500
μm.</description><subject>Acetylation</subject><subject>Alginate</subject><subject>Alginates - chemistry</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biological and medical sciences</subject><subject>Calcium - chemistry</subject><subject>Calcium compounds</subject><subject>Capsules</subject><subject>Cations - chemistry</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chitin - analogs & derivatives</subject><subject>Chitin - chemistry</subject><subject>Chitosan</subject><subject>Composition effects</subject><subject>Gels</subject><subject>Gels - chemistry</subject><subject>General pharmacology</subject><subject>Glucuronic Acid</subject><subject>Hexuronic Acids</subject><subject>Hydrogen-Ion Concentration</subject><subject>Medical sciences</subject><subject>Microcapsules</subject><subject>Miscellaneous</subject><subject>Molecular Weight</subject><subject>Osmolar Concentration</subject><subject>pH effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymeric membranes</subject><subject>Polysaccharides</subject><subject>Porosity</subject><subject>Sodium - chemistry</subject><subject>Sodium compounds</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtuFDEQhi0ECkPgCJG8QAgWnZRfbZtNFEU8IiViAaytGncNMepxT9ruoOy4Q27ISehJhtmyKpXqq78eP2NHAo4FiPbkKwgtG98K-da7dwBgVeOesIVw1jXGg3nKFnvkOXtRyk-Yc9DygB14Z4xwcsGGqxTHIeKmTD0VPqw49j9SxkpNvE51KJj5n9_3_OI9P-M3E-aaKtZ0S7zUqbvbNtRr4ilXGjHWNGS-pPqLKO-FOOaO_xN7yZ6tsC_0ahcP2fePH76df24uv3y6OD-7bKKyujZkdAcKiQQgYgfaimii8KvWRdUJ6qTQ2oMTthW69dZK5ZbWLAEMGUlKHbI3j7qbcbiZqNSwTiVS32OmYSrBgpAa2va_oBTKm3mnGTzagdNyTV3YjGmN413YvXKuv97VsUTsVyPmmMoeE8Zb6baLnT5iNF9_m2gMJSbKkbo0UqyhG1IQELYWhweLw9a_eUp4sDg49RfDIJhH</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>Gåserød, Olav</creator><creator>Smidsrød, Olav</creator><creator>Skjåk-Bræk, Gudmund</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19981001</creationdate><title>Microcapsules of alginate-chitosan – I: A quantitative study of the interaction between alginate and chitosan</title><author>Gåserød, Olav ; Smidsrød, Olav ; Skjåk-Bræk, Gudmund</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-e54d03aee10aaad0471c5c19f68c3d1ed2144908176146977238b75b005e52e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acetylation</topic><topic>Alginate</topic><topic>Alginates - chemistry</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biological and medical sciences</topic><topic>Calcium - chemistry</topic><topic>Calcium compounds</topic><topic>Capsules</topic><topic>Cations - chemistry</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chitin - analogs & derivatives</topic><topic>Chitin - chemistry</topic><topic>Chitosan</topic><topic>Composition effects</topic><topic>Gels</topic><topic>Gels - chemistry</topic><topic>General pharmacology</topic><topic>Glucuronic Acid</topic><topic>Hexuronic Acids</topic><topic>Hydrogen-Ion Concentration</topic><topic>Medical sciences</topic><topic>Microcapsules</topic><topic>Miscellaneous</topic><topic>Molecular Weight</topic><topic>Osmolar Concentration</topic><topic>pH effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymeric membranes</topic><topic>Polysaccharides</topic><topic>Porosity</topic><topic>Sodium - chemistry</topic><topic>Sodium compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gåserød, Olav</creatorcontrib><creatorcontrib>Smidsrød, Olav</creatorcontrib><creatorcontrib>Skjåk-Bræk, Gudmund</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gåserød, Olav</au><au>Smidsrød, Olav</au><au>Skjåk-Bræk, Gudmund</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microcapsules of alginate-chitosan – I: A quantitative study of the interaction between alginate and chitosan</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>19</volume><issue>20</issue><spage>1815</spage><epage>1825</epage><pages>1815-1825</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>The binding of chitosan to alginate beads was studied quantitatively by using radioactive labelled fractions of chitosan. The alginate-chitosan capsules were made either by dropping a solution of sodium alginate into a solution containing chitosan or by incubating calcium alginate beads in a solution of chitosan. The first procedure yielded a binding of 0.015
μg chitosan per mm
2 of capsule surface, while the latter procedure yielded over 2
μg
mm
-2. The maximum obtained weight ratio of chitosan to alginate in a microcapsule after 24
h was 0.40. The binding of chitosan was markedly increased by reducing the number average molecular weight of chitosan below 20000
Da and by increasing the porosity of the alginate gel. The porosity was increased by producing homogeneous gels, and by adding calcium chloride to the chitosan solution during the membrane forming stage. The effect of calcium ions on the porosity of the gel was studied by experiments involving release of blue dextran from calcium alginate beads. The binding of chitosan was also found to increase with decreasing fraction of N-acetylations,
F
A, on chitosan in the range of
F
A=0.3 to
F
A=0, and with increasing pH in the range from pH 4 to 6. Capsules with a diameter of 500
μm had a higher weight ratio of chitosan to alginate after 24
h of binding than the capsules with the larger diameter of 1500
μm.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9855182</pmid><doi>10.1016/S0142-9612(98)00073-8</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 1998-10, Vol.19 (20), p.1815-1825 |
| issn | 0142-9612 1878-5905 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylation Alginate Alginates - chemistry Biocompatible Materials - chemistry Biological and medical sciences Calcium - chemistry Calcium compounds Capsules Cations - chemistry Chemistry, Pharmaceutical Chitin - analogs & derivatives Chitin - chemistry Chitosan Composition effects Gels Gels - chemistry General pharmacology Glucuronic Acid Hexuronic Acids Hydrogen-Ion Concentration Medical sciences Microcapsules Miscellaneous Molecular Weight Osmolar Concentration pH effects Pharmacology. Drug treatments Polymeric membranes Polysaccharides Porosity Sodium - chemistry Sodium compounds |
| title | Microcapsules of alginate-chitosan – I: A quantitative study of the interaction between alginate and chitosan |
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