Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children
Asthma is a genetically complex disease, and the investigation of putative linkages to candidate loci in independent populations is an important part of the gene discovery process. This study investigated the linkage of microsatellite markers in the 5q and 11q regions to asthma-associated quantitati...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 1998-12, Vol.158 (6), p.1825-1830 |
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| creator | PALMER, L. J DANIELS, S. E RYE, P. J GIBSON, N. A TAY, G. K COOKSON, W. O. C. M GOLDBLATT, J BURTON, P. R LESOUËF, P. N |
| description | Asthma is a genetically complex disease, and the investigation of putative linkages to candidate loci in independent populations is an important part of the gene discovery process. This study investigated the linkage of microsatellite markers in the 5q and 11q regions to asthma-associated quantitative traits in 121 Australian Caucasian nuclear families. The families were recruited on the basis of a child proband: a cohort of 95 randomly recruited families of unselected probands (n = 442 subjects) and a cohort of 26 families of probands selected on the basis of severe symptomatic asthma (n = 134 subjects). The quantitative traits assessed included serum levels of total IgE and specific IgE to house dust mite and mixed grass, blood eosinophil counts, and the dose-response slope (DRS) of FEV1 to histamine provocation. Multipoint linkage analysis using Haseman-Elston sib-pair methods provided evidence of significant linkage between the chromosome 5q markers and loge total serum IgE levels, specific serum IgE levels, and loge blood eosinophil counts. The chromosome 11q markers showed evidence of significant linkage to specific serum IgE levels. Neither region demonstrated significant linkage to the loge DRS to histamine. Phenotypes were residualized for age and sex. These data are consistent with the existence of loci regulating asthma-associated quantitative traits in both the 5q31-33 and 11q13 chromosomal regions. |
| doi_str_mv | 10.1164/ajrccm.158.6.9804037 |
| format | Article |
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J ; DANIELS, S. E ; RYE, P. J ; GIBSON, N. A ; TAY, G. K ; COOKSON, W. O. C. M ; GOLDBLATT, J ; BURTON, P. R ; LESOUËF, P. N</creator><creatorcontrib>PALMER, L. J ; DANIELS, S. E ; RYE, P. J ; GIBSON, N. A ; TAY, G. K ; COOKSON, W. O. C. M ; GOLDBLATT, J ; BURTON, P. R ; LESOUËF, P. N</creatorcontrib><description>Asthma is a genetically complex disease, and the investigation of putative linkages to candidate loci in independent populations is an important part of the gene discovery process. This study investigated the linkage of microsatellite markers in the 5q and 11q regions to asthma-associated quantitative traits in 121 Australian Caucasian nuclear families. The families were recruited on the basis of a child proband: a cohort of 95 randomly recruited families of unselected probands (n = 442 subjects) and a cohort of 26 families of probands selected on the basis of severe symptomatic asthma (n = 134 subjects). The quantitative traits assessed included serum levels of total IgE and specific IgE to house dust mite and mixed grass, blood eosinophil counts, and the dose-response slope (DRS) of FEV1 to histamine provocation. Multipoint linkage analysis using Haseman-Elston sib-pair methods provided evidence of significant linkage between the chromosome 5q markers and loge total serum IgE levels, specific serum IgE levels, and loge blood eosinophil counts. The chromosome 11q markers showed evidence of significant linkage to specific serum IgE levels. Neither region demonstrated significant linkage to the loge DRS to histamine. Phenotypes were residualized for age and sex. These data are consistent with the existence of loci regulating asthma-associated quantitative traits in both the 5q31-33 and 11q13 chromosomal regions.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/ajrccm.158.6.9804037</identifier><identifier>PMID: 9847274</identifier><language>eng</language><publisher>New York, NY: American Lung Association</publisher><subject>Adolescent ; Adult ; Allergic diseases ; Animals ; Asthma - genetics ; Australia ; Biological and medical sciences ; Bronchial Provocation Tests ; Bronchoconstrictor Agents - administration & dosage ; Child ; Chromosome Mapping ; Chromosomes, Human, Pair 11 - genetics ; Chromosomes, Human, Pair 5 - genetics ; Cohort Studies ; Dose-Response Relationship, Drug ; Eosinophils - pathology ; Female ; Forced Expiratory Volume - drug effects ; Genetic Linkage - genetics ; Genetic Markers ; Histamine - administration & dosage ; Humans ; Immunoglobulin E - blood ; Immunopathology ; Leukocyte Count ; Longitudinal Studies ; Male ; Medical sciences ; Microsatellite Repeats - genetics ; Mites - immunology ; Phenotype ; Poaceae - immunology ; Respiratory and ent allergic diseases</subject><ispartof>American journal of respiratory and critical care medicine, 1998-12, Vol.158 (6), p.1825-1830</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-47d223d8f7bf9f391686f65cea819b783f5d4d623b456ecc42932de8c2e37ae13</citedby><cites>FETCH-LOGICAL-c331t-47d223d8f7bf9f391686f65cea819b783f5d4d623b456ecc42932de8c2e37ae13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1626120$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9847274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PALMER, L. J</creatorcontrib><creatorcontrib>DANIELS, S. E</creatorcontrib><creatorcontrib>RYE, P. J</creatorcontrib><creatorcontrib>GIBSON, N. A</creatorcontrib><creatorcontrib>TAY, G. K</creatorcontrib><creatorcontrib>COOKSON, W. O. C. M</creatorcontrib><creatorcontrib>GOLDBLATT, J</creatorcontrib><creatorcontrib>BURTON, P. R</creatorcontrib><creatorcontrib>LESOUËF, P. N</creatorcontrib><title>Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Asthma is a genetically complex disease, and the investigation of putative linkages to candidate loci in independent populations is an important part of the gene discovery process. This study investigated the linkage of microsatellite markers in the 5q and 11q regions to asthma-associated quantitative traits in 121 Australian Caucasian nuclear families. The families were recruited on the basis of a child proband: a cohort of 95 randomly recruited families of unselected probands (n = 442 subjects) and a cohort of 26 families of probands selected on the basis of severe symptomatic asthma (n = 134 subjects). The quantitative traits assessed included serum levels of total IgE and specific IgE to house dust mite and mixed grass, blood eosinophil counts, and the dose-response slope (DRS) of FEV1 to histamine provocation. Multipoint linkage analysis using Haseman-Elston sib-pair methods provided evidence of significant linkage between the chromosome 5q markers and loge total serum IgE levels, specific serum IgE levels, and loge blood eosinophil counts. The chromosome 11q markers showed evidence of significant linkage to specific serum IgE levels. Neither region demonstrated significant linkage to the loge DRS to histamine. Phenotypes were residualized for age and sex. These data are consistent with the existence of loci regulating asthma-associated quantitative traits in both the 5q31-33 and 11q13 chromosomal regions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergic diseases</subject><subject>Animals</subject><subject>Asthma - genetics</subject><subject>Australia</subject><subject>Biological and medical sciences</subject><subject>Bronchial Provocation Tests</subject><subject>Bronchoconstrictor Agents - administration & dosage</subject><subject>Child</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>Chromosomes, Human, Pair 5 - genetics</subject><subject>Cohort Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eosinophils - pathology</subject><subject>Female</subject><subject>Forced Expiratory Volume - drug effects</subject><subject>Genetic Linkage - genetics</subject><subject>Genetic Markers</subject><subject>Histamine - administration & dosage</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Immunopathology</subject><subject>Leukocyte Count</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsatellite Repeats - genetics</subject><subject>Mites - immunology</subject><subject>Phenotype</subject><subject>Poaceae - immunology</subject><subject>Respiratory and ent allergic diseases</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtr3TAQhUVpSNO0_6AFLUp3vtHLkrwMIX3AhW4a6M7MlUaJEtvKleRC_31UrmlXM8M5c5j5CPnA2Y5zra7gMTs373hvd3o3WKaYNK_IBe9l36nBsNetZ0Z2Sg2_3pC3pTwyxoXl7JycD1YZYdQFmfdxeYJ7pClQ95DTnEqakfZHCounnB_pPS5IZ8hPmAutiUKpDzN0UEpyESp6elxhqbFCjb-R1gyxFhoXer2WNkwRlpYcJ59xeUfOAkwF32_1ktx9uf15863b__j6_eZ63zkpee2U8UJIb4M5hCHIgWurg-4dguXDwVgZeq-8FvKgeo3OKTFI4dE6gdIAcnlJPp9yn3M6rljqOMficJpgwbSW0TQQrLeiGdXJ6HIqJWMYn3Nsz_4ZORv_Uh5PlMdGedTjRrmtfdzy18OM_t_ShrXpnzYdioMpZFhcLP-ztdDtAPkCvg-H_Q</recordid><startdate>19981201</startdate><enddate>19981201</enddate><creator>PALMER, L. J</creator><creator>DANIELS, S. E</creator><creator>RYE, P. J</creator><creator>GIBSON, N. A</creator><creator>TAY, G. K</creator><creator>COOKSON, W. O. C. M</creator><creator>GOLDBLATT, J</creator><creator>BURTON, P. R</creator><creator>LESOUËF, P. N</creator><general>American Lung Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981201</creationdate><title>Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children</title><author>PALMER, L. J ; DANIELS, S. E ; RYE, P. J ; GIBSON, N. A ; TAY, G. K ; COOKSON, W. O. C. M ; GOLDBLATT, J ; BURTON, P. R ; LESOUËF, P. N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-47d223d8f7bf9f391686f65cea819b783f5d4d623b456ecc42932de8c2e37ae13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergic diseases</topic><topic>Animals</topic><topic>Asthma - genetics</topic><topic>Australia</topic><topic>Biological and medical sciences</topic><topic>Bronchial Provocation Tests</topic><topic>Bronchoconstrictor Agents - administration & dosage</topic><topic>Child</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 11 - genetics</topic><topic>Chromosomes, Human, Pair 5 - genetics</topic><topic>Cohort Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eosinophils - pathology</topic><topic>Female</topic><topic>Forced Expiratory Volume - drug effects</topic><topic>Genetic Linkage - genetics</topic><topic>Genetic Markers</topic><topic>Histamine - administration & dosage</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Immunopathology</topic><topic>Leukocyte Count</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsatellite Repeats - genetics</topic><topic>Mites - immunology</topic><topic>Phenotype</topic><topic>Poaceae - immunology</topic><topic>Respiratory and ent allergic diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PALMER, L. J</creatorcontrib><creatorcontrib>DANIELS, S. E</creatorcontrib><creatorcontrib>RYE, P. J</creatorcontrib><creatorcontrib>GIBSON, N. A</creatorcontrib><creatorcontrib>TAY, G. K</creatorcontrib><creatorcontrib>COOKSON, W. O. C. M</creatorcontrib><creatorcontrib>GOLDBLATT, J</creatorcontrib><creatorcontrib>BURTON, P. R</creatorcontrib><creatorcontrib>LESOUËF, P. N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PALMER, L. J</au><au>DANIELS, S. E</au><au>RYE, P. J</au><au>GIBSON, N. A</au><au>TAY, G. K</au><au>COOKSON, W. O. C. M</au><au>GOLDBLATT, J</au><au>BURTON, P. R</au><au>LESOUËF, P. N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>158</volume><issue>6</issue><spage>1825</spage><epage>1830</epage><pages>1825-1830</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Asthma is a genetically complex disease, and the investigation of putative linkages to candidate loci in independent populations is an important part of the gene discovery process. This study investigated the linkage of microsatellite markers in the 5q and 11q regions to asthma-associated quantitative traits in 121 Australian Caucasian nuclear families. The families were recruited on the basis of a child proband: a cohort of 95 randomly recruited families of unselected probands (n = 442 subjects) and a cohort of 26 families of probands selected on the basis of severe symptomatic asthma (n = 134 subjects). The quantitative traits assessed included serum levels of total IgE and specific IgE to house dust mite and mixed grass, blood eosinophil counts, and the dose-response slope (DRS) of FEV1 to histamine provocation. Multipoint linkage analysis using Haseman-Elston sib-pair methods provided evidence of significant linkage between the chromosome 5q markers and loge total serum IgE levels, specific serum IgE levels, and loge blood eosinophil counts. The chromosome 11q markers showed evidence of significant linkage to specific serum IgE levels. Neither region demonstrated significant linkage to the loge DRS to histamine. Phenotypes were residualized for age and sex. These data are consistent with the existence of loci regulating asthma-associated quantitative traits in both the 5q31-33 and 11q13 chromosomal regions.</abstract><cop>New York, NY</cop><pub>American Lung Association</pub><pmid>9847274</pmid><doi>10.1164/ajrccm.158.6.9804037</doi><tpages>6</tpages></addata></record> |
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| ispartof | American journal of respiratory and critical care medicine, 1998-12, Vol.158 (6), p.1825-1830 |
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| source | MEDLINE; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Allergic diseases Animals Asthma - genetics Australia Biological and medical sciences Bronchial Provocation Tests Bronchoconstrictor Agents - administration & dosage Child Chromosome Mapping Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 5 - genetics Cohort Studies Dose-Response Relationship, Drug Eosinophils - pathology Female Forced Expiratory Volume - drug effects Genetic Linkage - genetics Genetic Markers Histamine - administration & dosage Humans Immunoglobulin E - blood Immunopathology Leukocyte Count Longitudinal Studies Male Medical sciences Microsatellite Repeats - genetics Mites - immunology Phenotype Poaceae - immunology Respiratory and ent allergic diseases |
| title | Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children |
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