Loss of laminin and of the laminin receptor integrin subunit alpha 6 in situ correlates with cytokine induced down regulation of alpha 6 on fibroblast-like synoviocytes from rheumatoid arthritis

To investigate in situ the expression of the integrin receptor subunits alpha 6 and beta 1 and the distribution of the ligand laminin in the synovia from osteoarthritis (OA) and rheumatoid arthritis (RA) patients and to study the effect of cytokines and antirheumatic drugs on the expression of the a...

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Veröffentlicht in:	Annals of the rheumatic diseases 1998-09, Vol.57 (9), p.559-565
Hauptverfasser:	Rinaldi, N, Barth, T F, Weis, D, Schwarz-Eywill, M, Pezzutto, A, Lukoschek, M, Brocai, D, Brado, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - drug effects Antigens, CD - metabolism Antirheumatic Agents - pharmacology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Cell Culture Techniques Cytokines - pharmacology Down-Regulation Humans Immunoenzyme Techniques Integrin alpha6 Integrin beta1 - drug effects Integrin beta1 - metabolism Integrins - drug effects Integrins - metabolism Laminin - metabolism Osteoarthritis - metabolism Osteoarthritis - pathology Synovial Membrane - metabolism
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