Effects of trimebutine maleate on gastric motility in patients with gastric ulcer
The effects of trimebutine maleate (TM), a prokinetic drug, on gastrointestinal motility in patients with gastric ulcer were investigated. Twenty patients with active gastric ulcers were allocated to two groups; 10 patients received a proton pump inhibitor alone (PPI group), given orally, and 10 pat...
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| Veröffentlicht in: | Journal of gastroenterology 1998-12, Vol.33 (6), p.823-827 |
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| creator | Kamiya, T Nagao, T Andou, T Misu, N Kobayashi, Y Hirako, M Hara, M Fujinami, T |
| description | The effects of trimebutine maleate (TM), a prokinetic drug, on gastrointestinal motility in patients with gastric ulcer were investigated. Twenty patients with active gastric ulcers were allocated to two groups; 10 patients received a proton pump inhibitor alone (PPI group), given orally, and 10 patients received oral TM in combination with a PPI (PPI + TM group), each for a period of 8 weeks. Electrogastrography (EGG) and gastric emptying were measured before and after the treatment period. During the active ulcer stage, tachygastria (more than 0.06 Hz) or bradygastria (less than 0.04 Hz) in the EGG frequency were observed in 9 patients either before or after meals. During the healed ulcer stage, tachygastria or bradygastria was observed in 4 of 10 patients in the PPI group, while in the PPI + TM group, 1 patient had tachygastria and none had bradygastria. Postprandial dip (PD) was observed in 3 of the 20 patients during the active stage, while after treatment, PD was observed in 3 patients in the PPI group and in 6 patients in the PPI + TM group, respectively. Gastric emptying in the PPI group did not show any change between before and after treatment, while that in the PPI + TM group improved significantly after treatment. These results suggest that TM may have an ameliorative effect on abnormal gastric motility in patients with gastric ulcer. |
| doi_str_mv | 10.1007/s005350050182 |
| format | Article |
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Twenty patients with active gastric ulcers were allocated to two groups; 10 patients received a proton pump inhibitor alone (PPI group), given orally, and 10 patients received oral TM in combination with a PPI (PPI + TM group), each for a period of 8 weeks. Electrogastrography (EGG) and gastric emptying were measured before and after the treatment period. During the active ulcer stage, tachygastria (more than 0.06 Hz) or bradygastria (less than 0.04 Hz) in the EGG frequency were observed in 9 patients either before or after meals. During the healed ulcer stage, tachygastria or bradygastria was observed in 4 of 10 patients in the PPI group, while in the PPI + TM group, 1 patient had tachygastria and none had bradygastria. Postprandial dip (PD) was observed in 3 of the 20 patients during the active stage, while after treatment, PD was observed in 3 patients in the PPI group and in 6 patients in the PPI + TM group, respectively. Gastric emptying in the PPI group did not show any change between before and after treatment, while that in the PPI + TM group improved significantly after treatment. These results suggest that TM may have an ameliorative effect on abnormal gastric motility in patients with gastric ulcer.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s005350050182</identifier><identifier>PMID: 9853554</identifier><language>eng</language><publisher>Japan</publisher><subject>2-Pyridinylmethylsulfinylbenzimidazoles ; Administration, Oral ; Adult ; Drug Therapy, Combination ; Enzyme Inhibitors - administration & dosage ; Female ; Follow-Up Studies ; Gastric Emptying - drug effects ; Gastric Mucosa - drug effects ; Gastrointestinal Agents - administration & dosage ; Gastrointestinal Motility - drug effects ; Gastroscopy ; Humans ; Lansoprazole ; Male ; Middle Aged ; Omeprazole - administration & dosage ; Omeprazole - analogs & derivatives ; Stomach Ulcer - diagnosis ; Stomach Ulcer - drug therapy ; Stomach Ulcer - physiopathology ; Treatment Outcome ; Trimebutine - administration & dosage</subject><ispartof>Journal of gastroenterology, 1998-12, Vol.33 (6), p.823-827</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-902b7c8b172417b4929e1545bd4c63b94504303c46a363b5e93cd2d5b06bad643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9853554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamiya, T</creatorcontrib><creatorcontrib>Nagao, T</creatorcontrib><creatorcontrib>Andou, T</creatorcontrib><creatorcontrib>Misu, N</creatorcontrib><creatorcontrib>Kobayashi, Y</creatorcontrib><creatorcontrib>Hirako, M</creatorcontrib><creatorcontrib>Hara, M</creatorcontrib><creatorcontrib>Fujinami, T</creatorcontrib><title>Effects of trimebutine maleate on gastric motility in patients with gastric ulcer</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><description>The effects of trimebutine maleate (TM), a prokinetic drug, on gastrointestinal motility in patients with gastric ulcer were investigated. Twenty patients with active gastric ulcers were allocated to two groups; 10 patients received a proton pump inhibitor alone (PPI group), given orally, and 10 patients received oral TM in combination with a PPI (PPI + TM group), each for a period of 8 weeks. Electrogastrography (EGG) and gastric emptying were measured before and after the treatment period. During the active ulcer stage, tachygastria (more than 0.06 Hz) or bradygastria (less than 0.04 Hz) in the EGG frequency were observed in 9 patients either before or after meals. During the healed ulcer stage, tachygastria or bradygastria was observed in 4 of 10 patients in the PPI group, while in the PPI + TM group, 1 patient had tachygastria and none had bradygastria. Postprandial dip (PD) was observed in 3 of the 20 patients during the active stage, while after treatment, PD was observed in 3 patients in the PPI group and in 6 patients in the PPI + TM group, respectively. Gastric emptying in the PPI group did not show any change between before and after treatment, while that in the PPI + TM group improved significantly after treatment. These results suggest that TM may have an ameliorative effect on abnormal gastric motility in patients with gastric ulcer.</description><subject>2-Pyridinylmethylsulfinylbenzimidazoles</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Drug Therapy, Combination</subject><subject>Enzyme Inhibitors - administration & dosage</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastric Emptying - drug effects</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastrointestinal Agents - administration & dosage</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Gastroscopy</subject><subject>Humans</subject><subject>Lansoprazole</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Omeprazole - administration & dosage</subject><subject>Omeprazole - analogs & derivatives</subject><subject>Stomach Ulcer - diagnosis</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - physiopathology</subject><subject>Treatment Outcome</subject><subject>Trimebutine - administration & dosage</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1LxDAQxYMo67p69Cjk5K060yRtcxTxCxZE0HNJ0qlG-rE2KeJ_b2SXBS8zDPN7D95j7BzhCgHK6wCghEoDsMoP2BKlUJnSeX7IlqClzBBLecxOQvgEQAGqWrCFrpJGySV7uWtbcjHwseVx8j3ZOfqBeG86MpH4OPB3E9LH8X6MvvPxh_uBb0z0NCTZt48fe2LuHE2n7Kg1XaCz3V6xt_u719vHbP388HR7s86cwDJmGnJbuspimUssrdS5JlRS2Ua6QlgtFUgBwsnCiHQr0sI1eaMsFNY0hRQrdrn13Uzj10wh1r0PjrrODDTOoS4BsagQE5htQTeNIUzU1psU1Ew_NUL9V2H9r8LEX-yMZ9tTs6d3nYlfF3drLg</recordid><startdate>19981201</startdate><enddate>19981201</enddate><creator>Kamiya, T</creator><creator>Nagao, T</creator><creator>Andou, T</creator><creator>Misu, N</creator><creator>Kobayashi, Y</creator><creator>Hirako, M</creator><creator>Hara, M</creator><creator>Fujinami, T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>19981201</creationdate><title>Effects of trimebutine maleate on gastric motility in patients with gastric ulcer</title><author>Kamiya, T ; Nagao, T ; Andou, T ; Misu, N ; Kobayashi, Y ; Hirako, M ; Hara, M ; Fujinami, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-902b7c8b172417b4929e1545bd4c63b94504303c46a363b5e93cd2d5b06bad643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>2-Pyridinylmethylsulfinylbenzimidazoles</topic><topic>Administration, Oral</topic><topic>Adult</topic><topic>Drug Therapy, Combination</topic><topic>Enzyme Inhibitors - administration & dosage</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastric Emptying - drug effects</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastrointestinal Agents - administration & dosage</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Gastroscopy</topic><topic>Humans</topic><topic>Lansoprazole</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Omeprazole - administration & dosage</topic><topic>Omeprazole - analogs & derivatives</topic><topic>Stomach Ulcer - diagnosis</topic><topic>Stomach Ulcer - drug therapy</topic><topic>Stomach Ulcer - physiopathology</topic><topic>Treatment Outcome</topic><topic>Trimebutine - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamiya, T</creatorcontrib><creatorcontrib>Nagao, T</creatorcontrib><creatorcontrib>Andou, T</creatorcontrib><creatorcontrib>Misu, N</creatorcontrib><creatorcontrib>Kobayashi, Y</creatorcontrib><creatorcontrib>Hirako, M</creatorcontrib><creatorcontrib>Hara, M</creatorcontrib><creatorcontrib>Fujinami, T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamiya, T</au><au>Nagao, T</au><au>Andou, T</au><au>Misu, N</au><au>Kobayashi, Y</au><au>Hirako, M</au><au>Hara, M</au><au>Fujinami, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of trimebutine maleate on gastric motility in patients with gastric ulcer</atitle><jtitle>Journal of gastroenterology</jtitle><addtitle>J Gastroenterol</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>33</volume><issue>6</issue><spage>823</spage><epage>827</epage><pages>823-827</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>The effects of trimebutine maleate (TM), a prokinetic drug, on gastrointestinal motility in patients with gastric ulcer were investigated. Twenty patients with active gastric ulcers were allocated to two groups; 10 patients received a proton pump inhibitor alone (PPI group), given orally, and 10 patients received oral TM in combination with a PPI (PPI + TM group), each for a period of 8 weeks. Electrogastrography (EGG) and gastric emptying were measured before and after the treatment period. During the active ulcer stage, tachygastria (more than 0.06 Hz) or bradygastria (less than 0.04 Hz) in the EGG frequency were observed in 9 patients either before or after meals. During the healed ulcer stage, tachygastria or bradygastria was observed in 4 of 10 patients in the PPI group, while in the PPI + TM group, 1 patient had tachygastria and none had bradygastria. Postprandial dip (PD) was observed in 3 of the 20 patients during the active stage, while after treatment, PD was observed in 3 patients in the PPI group and in 6 patients in the PPI + TM group, respectively. Gastric emptying in the PPI group did not show any change between before and after treatment, while that in the PPI + TM group improved significantly after treatment. These results suggest that TM may have an ameliorative effect on abnormal gastric motility in patients with gastric ulcer.</abstract><cop>Japan</cop><pmid>9853554</pmid><doi>10.1007/s005350050182</doi><tpages>5</tpages></addata></record> |
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| subjects | 2-Pyridinylmethylsulfinylbenzimidazoles Administration, Oral Adult Drug Therapy, Combination Enzyme Inhibitors - administration & dosage Female Follow-Up Studies Gastric Emptying - drug effects Gastric Mucosa - drug effects Gastrointestinal Agents - administration & dosage Gastrointestinal Motility - drug effects Gastroscopy Humans Lansoprazole Male Middle Aged Omeprazole - administration & dosage Omeprazole - analogs & derivatives Stomach Ulcer - diagnosis Stomach Ulcer - drug therapy Stomach Ulcer - physiopathology Treatment Outcome Trimebutine - administration & dosage |
| title | Effects of trimebutine maleate on gastric motility in patients with gastric ulcer |
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