Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes

Analysis of minimal residual disease (MRD) can predict outcome in acute lymphoblastic leukemia (ALL). A large prospective study in childhood ALL has shown that MRD analysis using immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements as PCR targets can identify good and poor prognosis gro...

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Veröffentlicht in:	Leukemia 1998-12, Vol.12 (12), p.2006-2014
Hauptverfasser:	PONGERS-WILLEMSE, M. J, VERHAGEN, O. J. H. M, TIBBE, G. J. M, WIJKHUIJS, A. J. M, DE HAAS, V, ROOVERS, E, VAN DER SCHOOT, C. E, VAN DONGEN, J. J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adult Automation Biological and medical sciences Bone marrow Child Children DNA Probes - genetics Gene Rearrangement, T-Lymphocyte Genes, Immunoglobulin Genes, T-Cell Receptor Heavy chains Hematology Humans Hybridization IGK gene Immunoglobulins Investigative techniques, diagnostic techniques (general aspects) Leukemia Lymphatic leukemia Lymphocytes Lymphocytes T Medical sciences Minimal residual disease Neoplasm, Residual - diagnosis Neoplasm, Residual - genetics Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Patients Polymerase Chain Reaction - methods Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Probes Real time Sensitivity Sensitivity and Specificity T cell receptors Target recognition Technology Tumors
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