Purification and Characterization of a Membrane Bound Neutral pH Optimum Magnesium-dependent and Phosphatidylserine-stimulated Sphingomyelinase from Rat Brain

Sphingomyelin hydrolysis and ceramide generation catalyzed by sphingomyelinases (SMase) are key components of the signaling pathways in cytokine- and stress-induced cellular responses. In this study, we report the partial purification and characterization of the membrane bound, neutral pH optimal, a...

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Veröffentlicht in:	The Journal of biological chemistry 1998-12, Vol.273 (51), p.34472-34479
Hauptverfasser:	Liu, B, Hassler, D F, Smith, G K, Weaver, K, Hannun, Y A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - enzymology Cations, Divalent - pharmacology Cell Membrane - enzymology Chromatography, Affinity Chromatography, Gel Chromatography, Ion Exchange Hydrogen-Ion Concentration Isoelectric Focusing Kinetics Magnesium - pharmacology Phosphatidylserines - pharmacology Rats Sphingomyelin Phosphodiesterase - isolation & purification Sphingomyelin Phosphodiesterase - metabolism
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