The Effect of Number of Days in Culture and Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G Genotype on PAI-1 Antigen Release by Cultured Human Umbilical Vein Endothelial Cells

An insertion/deletion (4G/5G) polymorphism in what has been shown to be an enhancer/repressor binding site in the promoter region of the PAI-1 gene has been related to plasma PAI-1 activity. Transfection studies demonstrated increased interleukin-1 stimulated PAI-1 synthesis in cells containing the...

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Veröffentlicht in:	Thrombosis research 1998-12, Vol.92 (5), p.199-206
Hauptverfasser:	McCormack, Lynn J., Semple, Jennifer I., Stickland, Max H., Barrett, Jennifer H., Grant, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Antigens - metabolism Biological and medical sciences Blood coagulation. Blood cells Cells, Cultured Cytokines Endothelial cells Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Fibrinolysis Fundamental and applied biological sciences. Psychology General aspects, investigation methods, hemostasis, fibrinolysis Genetic polymorphism Genotype Humans Infant, Newborn Interleukin-1 - pharmacology Molecular and cellular biology Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - immunology Plasminogen Activator Inhibitor 1 - physiology Plasminogen activator inhibitor-1 Serine Proteinase Inhibitors - genetics Serine Proteinase Inhibitors - immunology Serine Proteinase Inhibitors - physiology Time Factors Tumor Necrosis Factor-alpha - pharmacology Umbilical Veins
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