Advanced onset of menarche and higher bone mineral density depending on vitamin D receptor gene polymorphism
Bone mineral density (BMD) at distal forearm, and weight and height of healthy Japanese girls aged 18-19 years were measured and their age at menarche was obtained through a questionnaire. A statistically significant association was found between BMD at distal radius and vitamin D receptor (VDR) gen...
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| Veröffentlicht in: | European journal of endocrinology 1998-11, Vol.139 (5), p.522-527 |
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| container_title | European journal of endocrinology |
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| creator | Kitagawa, I Kitagawa, Y Kawase, Y Nagaya, T Tokudome, S |
| description | Bone mineral density (BMD) at distal forearm, and weight and height of healthy Japanese girls aged 18-19 years were measured and their age at menarche was obtained through a questionnaire. A statistically significant association was found between BMD at distal radius and vitamin D receptor (VDR) gene polymorphism at the ApaI site. The age at menarche in the population with Aa genotype was significantly earlier than that in the aa population. In addition, BMD was significantly dependent on the earlier onset of menarche in the population with genotype Aa but not in the population with genotype aa. BMD was also positively associated with the body mass index (BMI) in the population with genotype Aa. Statistical analysis suggested a stronger effect of VDR genotype on age at menarche than on BMI. Thus, we show that VDR gene polymorphism advances the age at menarche and increases BMD in cooperation with age at menarche. |
| doi_str_mv | 10.1530/eje.0.1390522 |
| format | Article |
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A statistically significant association was found between BMD at distal radius and vitamin D receptor (VDR) gene polymorphism at the ApaI site. The age at menarche in the population with Aa genotype was significantly earlier than that in the aa population. In addition, BMD was significantly dependent on the earlier onset of menarche in the population with genotype Aa but not in the population with genotype aa. BMD was also positively associated with the body mass index (BMI) in the population with genotype Aa. Statistical analysis suggested a stronger effect of VDR genotype on age at menarche than on BMI. Thus, we show that VDR gene polymorphism advances the age at menarche and increases BMD in cooperation with age at menarche.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/eje.0.1390522</identifier><identifier>PMID: 9849817</identifier><language>eng</language><publisher>Colchester: European Society of Endocrinology</publisher><subject>Absorptiometry, Photon ; Adolescent ; Adult ; Biological and medical sciences ; Bone Density - genetics ; Clinical Studies ; DNA - analysis ; DNA - genetics ; DNA - isolation & purification ; Female ; Fundamental and applied biological sciences. Psychology ; Genotype ; Humans ; Japan ; Menarche - genetics ; Polymorphism, Genetic - genetics ; Polymorphism, Restriction Fragment Length ; Receptors, Calcitriol - genetics ; Sexual differentiation and maturation. Puberty. Climacterium ; Vertebrates: reproduction</subject><ispartof>European journal of endocrinology, 1998-11, Vol.139 (5), p.522-527</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b438t-771a891c4e02feca96e74e55583419abc77de75685fae143f2bc1b9aba9353cf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1601700$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9849817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kitagawa, I</creatorcontrib><creatorcontrib>Kitagawa, Y</creatorcontrib><creatorcontrib>Kawase, Y</creatorcontrib><creatorcontrib>Nagaya, T</creatorcontrib><creatorcontrib>Tokudome, S</creatorcontrib><title>Advanced onset of menarche and higher bone mineral density depending on vitamin D receptor gene polymorphism</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>Bone mineral density (BMD) at distal forearm, and weight and height of healthy Japanese girls aged 18-19 years were measured and their age at menarche was obtained through a questionnaire. A statistically significant association was found between BMD at distal radius and vitamin D receptor (VDR) gene polymorphism at the ApaI site. The age at menarche in the population with Aa genotype was significantly earlier than that in the aa population. In addition, BMD was significantly dependent on the earlier onset of menarche in the population with genotype Aa but not in the population with genotype aa. BMD was also positively associated with the body mass index (BMI) in the population with genotype Aa. Statistical analysis suggested a stronger effect of VDR genotype on age at menarche than on BMI. Thus, we show that VDR gene polymorphism advances the age at menarche and increases BMD in cooperation with age at menarche.</description><subject>Absorptiometry, Photon</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bone Density - genetics</subject><subject>Clinical Studies</subject><subject>DNA - analysis</subject><subject>DNA - genetics</subject><subject>DNA - isolation & purification</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Japan</subject><subject>Menarche - genetics</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Sexual differentiation and maturation. Puberty. Climacterium</subject><subject>Vertebrates: reproduction</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LAzEUxIMoWj-OHoUI4m1r0iSb3WOpnyB4UfC2ZLMvbWQ3WZNtof-9KVvq6Q3Mb-bBIHRNyZQKRh7gB6ZJspKI2ewITSiXZZYX7PsYTUhBeMZzzs7QeYw_hNCkySk6LQteFlROUDtvNsppaLB3EQbsDe7AqaBXgJVr8MouVxBw7R3gzjoIqsUNuGiHbbo9uMa6ZcrijR1UAvAjDqChH3zAS0ih3rfbzod-ZWN3iU6MaiNc7e8F-np--ly8Zu8fL2-L-XtWc1YMmZRUFSXVHMjMgFZlDpKDEKJgnJaq1lI2IEVeCKOAcmZmtaZ1MlTJBNOGXaD7sbcP_ncNcag6GzW0rXLg17GShFIuCEtgNoI6-BgDmKoPtlNhW1FS7dat0rpVkuO6ib_ZF6_rDpoDvZ8z-Xd7X0WtWhPStDb-l-aESkISdjtitfVRW3CDNVarA7d79QfkFo_9</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>Kitagawa, I</creator><creator>Kitagawa, Y</creator><creator>Kawase, Y</creator><creator>Nagaya, T</creator><creator>Tokudome, S</creator><general>European Society of Endocrinology</general><general>Portland Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981101</creationdate><title>Advanced onset of menarche and higher bone mineral density depending on vitamin D receptor gene polymorphism</title><author>Kitagawa, I ; Kitagawa, Y ; Kawase, Y ; Nagaya, T ; Tokudome, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b438t-771a891c4e02feca96e74e55583419abc77de75685fae143f2bc1b9aba9353cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Absorptiometry, Photon</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bone Density - genetics</topic><topic>Clinical Studies</topic><topic>DNA - analysis</topic><topic>DNA - genetics</topic><topic>DNA - isolation & purification</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Humans</topic><topic>Japan</topic><topic>Menarche - genetics</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Sexual differentiation and maturation. Puberty. Climacterium</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kitagawa, I</creatorcontrib><creatorcontrib>Kitagawa, Y</creatorcontrib><creatorcontrib>Kawase, Y</creatorcontrib><creatorcontrib>Nagaya, T</creatorcontrib><creatorcontrib>Tokudome, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kitagawa, I</au><au>Kitagawa, Y</au><au>Kawase, Y</au><au>Nagaya, T</au><au>Tokudome, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced onset of menarche and higher bone mineral density depending on vitamin D receptor gene polymorphism</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>139</volume><issue>5</issue><spage>522</spage><epage>527</epage><pages>522-527</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>Bone mineral density (BMD) at distal forearm, and weight and height of healthy Japanese girls aged 18-19 years were measured and their age at menarche was obtained through a questionnaire. A statistically significant association was found between BMD at distal radius and vitamin D receptor (VDR) gene polymorphism at the ApaI site. The age at menarche in the population with Aa genotype was significantly earlier than that in the aa population. In addition, BMD was significantly dependent on the earlier onset of menarche in the population with genotype Aa but not in the population with genotype aa. BMD was also positively associated with the body mass index (BMI) in the population with genotype Aa. Statistical analysis suggested a stronger effect of VDR genotype on age at menarche than on BMI. Thus, we show that VDR gene polymorphism advances the age at menarche and increases BMD in cooperation with age at menarche.</abstract><cop>Colchester</cop><pub>European Society of Endocrinology</pub><pmid>9849817</pmid><doi>10.1530/eje.0.1390522</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of endocrinology, 1998-11, Vol.139 (5), p.522-527 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Absorptiometry, Photon Adolescent Adult Biological and medical sciences Bone Density - genetics Clinical Studies DNA - analysis DNA - genetics DNA - isolation & purification Female Fundamental and applied biological sciences. Psychology Genotype Humans Japan Menarche - genetics Polymorphism, Genetic - genetics Polymorphism, Restriction Fragment Length Receptors, Calcitriol - genetics Sexual differentiation and maturation. Puberty. Climacterium Vertebrates: reproduction |
| title | Advanced onset of menarche and higher bone mineral density depending on vitamin D receptor gene polymorphism |
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