Stable sugar-based protein formulations by supercritical fluid drying

The aim of this work was to produce stable, sugar-containing protein formulations by supercritical fluid (SCF) drying. Lysozyme solutions with and without added sucrose or trehalose were dried by spraying them in an SCF composed of CO 2 and ethanol or CO 2 only. The protein-to-sugar ratio was varied...

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Veröffentlicht in:	International journal of pharmaceutics 2008-01, Vol.346 (1), p.102-108
Hauptverfasser:	Jovanović, Nataša, Bouchard, Andréanne, Sutter, Marc, Van Speybroeck, Michiel, Hofland, Gerard W., Witkamp, Geert-Jan, Crommelin, Daan J.A., Jiskoot, Wim
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry, Differential Scanning Carbon Dioxide - chemistry Crystallization Desiccation - methods Drug Compounding - methods Drug Stability Drug Storage Ethanol - analysis Ethanol - chemistry FTIR Lysozyme Microscopy, Electron, Scanning Muramidase - chemistry Muramidase - metabolism Particle Size Powders Protein stabilization Protein structure Spectroscopy, Fourier Transform Infrared Sucrose Sucrose - chemistry Supercritical fluid drying Trehalose Trehalose - chemistry Water - analysis X-Ray Diffraction
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