Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma

DNA amplification is one of the mechanisms to activate genes that are implicated in neoplastic transformation and gain of chromosome band 3q26 is a common event in squamous cell carcinomas. The aim of the present work was to identify the specific target gene from four candidates (MDS1, PRKCI, ECT2,...

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Veröffentlicht in:	Genes chromosomes & cancer 2008-02, Vol.47 (2), p.127-136
Hauptverfasser:	Yang, Yi-Ling, Chu, Jia-You, Luo, Man-Li, Wu, Yu-Peng, Zhang, Yu, Feng, Yan-Bin, Shi, Zhi-Zhou, Xu, Xin, Han, Ya-Ling, Cai, Yan, Dong, Jin-Tang, Zhan, Qi-Min, Wu, Min, Wang, Ming-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell Line, Tumor Chromosomes, Human, Pair 3 - genetics Disease Progression Esophageal Neoplasms - enzymology Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Female Gene Amplification Gene Dosage Humans Isoenzymes - biosynthesis Isoenzymes - genetics Isoenzymes - metabolism Lymphatic Metastasis Male Middle Aged Protein Kinase C - biosynthesis Protein Kinase C - genetics Protein Kinase C - metabolism
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