A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes

The ability to produce monoclonal antibodies (Mabs) in plants offers the opportunity for the development of an inexpensive method of mucosal immunoprotection against sexually transmitted diseases. To investigate the suitability of plant-expressed Mabs for vaginal preventive applications, we compared...

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Veröffentlicht in:	Nature biotechnology 1998-12, Vol.16 (13), p.1361-1364
Hauptverfasser:	Whaley, Kevin J, Zeitlin, Larry, Olmsted, Stuart S, Moench, Thomas R, Co, Man Sung, Martinell, Brian J, Paradkar, Vikram M, Russell, David R, Queen, Cary, Cone, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Biological and medical sciences Biotechnology Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Herpes Genitalis - immunology Herpes Genitalis - prevention & control Herpes simplex virus 2 Herpesvirus 2, Human - isolation & purification Humans Immunity, Mucosal Industrial applications and implications. Economical aspects Mice Monoclonal antibodies Plants, Genetically Modified - genetics Production of active biomolecules Vagina - immunology Vagina - virology
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