2,2'-Dithiobisbenzamides derived from alpha-, beta- and gamma-amino acids possessing anti-HIV activities: synthesis and structure-activity relationship

Nucleocapsid protein (NCp7), which contains highly conserved retroviral zinc fingers, is essential in the early as well as the late phase of human immunodeficiency virus (HIV) life cycle and constitutes a novel target for AIDS therapy. HIV-1 NCp7 is a basic 55 amino acid protein containing two C(X)2...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 1998-10, Vol.6 (10), p.1707-1730
Hauptverfasser:	Prasad, J V, Loo, J A, Boyer, F E, Stier, M A, Gogliotti, R D, Turner, W J, Harvey, P J, Kramer, M R, Mack, D P, Scholten, J D, Gracheck, S J, Domagala, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Amino Acids - chemistry Anti-HIV Agents - chemistry Anti-HIV Agents - metabolism Anti-HIV Agents - pharmacology Benzamides - chemistry Capsid - chemistry Capsid - drug effects Capsid Proteins gag Gene Products, Human Immunodeficiency Virus Gene Products, gag - chemistry Gene Products, gag - drug effects Humans Mass Spectrometry - methods Molecular Sequence Data Sp1 Transcription Factor - metabolism Structure-Activity Relationship Viral Proteins Zinc - chemistry
Online-Zugang:	Volltext
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