Synthesis of Tn, sialyl Tn and HIV-1-derived peptide antigen conjugates having a lipid A analog as an immunoadjuvant for synthetic vaccines

Conjugates (3-5) of Tn, sialyl Tn and HIV-1-derived peptide antigen with a N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine derivative, structurally related to lipid A, as an immunoadjuvant for the development of totally synthetic vaccines against cancers or HIV were synthesized. The m...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1998-11, Vol.46 (11), p.1676-1682
Hauptverfasser:	MIYAJIMA, K, NEKADO, T, IKEDA, K, ACHIWA, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - chemistry AIDS/HIV Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antigens, Tumor-Associated, Carbohydrate - chemistry Antineoplastic agents Antiviral agents Biological and medical sciences Carbohydrate Sequence Human immunodeficiency virus Immunotherapy Lipid A - analogs & derivatives Lipid A - chemistry Magnetic Resonance Spectroscopy Medical sciences Mice Mice, Inbred C3H Molecular Sequence Data Pharmacology. Drug treatments Spectrophotometry, Infrared Vaccines, Synthetic - chemistry
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Zusammenfassung:	Conjugates (3-5) of Tn, sialyl Tn and HIV-1-derived peptide antigen with a N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine derivative, structurally related to lipid A, as an immunoadjuvant for the development of totally synthetic vaccines against cancers or HIV were synthesized. The mitogenic activity of compounds 3, 4 and 5 was stronger than that of lipid A analogs (1, 2).
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.46.1676