Reduced COX-2 protein in colorectal cancer with defective mismatch repair

Most colorectal adenomas and carcinomas arise in the setting of chromosomal instability characterized by progressive loss of heterozygosity. In contrast, approximately 15-20% of colorectal neoplasms arise through a distinct genetic pathway characterized by microsatellite instability (MSI) associated...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1998-12, Vol.58 (23), p.5473-5477
Hauptverfasser:	KARNES, W. E, SHATTUCK-BRANDT, R, BURGART, L. J, DUBOIS, R. N, TESTER, D. J, CUNNINGHAM, J. M, KIM, C.-Y, MCDONNELL, S. K, SCHAID, D. J, THIBODEAU, S. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adult Aged Aged, 80 and over Biological and medical sciences Carrier Proteins Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Cyclooxygenase 2 DNA Repair DNA-Binding Proteins Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Isoenzymes - biosynthesis Male Medical sciences Membrane Proteins Microsatellite Repeats Middle Aged MutL Protein Homolog 1 MutS Homolog 2 Protein Neoplasm Proteins - biosynthesis Nuclear Proteins Prospective Studies Prostaglandin-Endoperoxide Synthases - biosynthesis Proto-Oncogene Proteins - biosynthesis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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